Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    The State and the Life Course (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Sociology 15 (1989), S. 187-209 
    Details
    ISSN: 0360-0572
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Sociologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.so.15.080189.001155
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Vaccinations with T-helper type 1 directing adjuvants have different suppressive effects on the development of allergen-induced T-helper type 2 responses (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Allergen-induced T-helper type 2 (Th2) responses can be inhibited with Th1 directing vaccines. However, studies comparing the efficacy of the different adjuvants have not been performed in detail.Objective For this reason we compare the effects of live Bacillus–Calmette–Guerin(BCG), heat-killed (hk)-BCG, CpG-ODN (oligodeoxynucleotide) or PPD on the development of allergen-induced Th2 responses in mice.Methods Ovalbumin (OVA)-specific allergic responses were induced in C57BL/6 mice by two intraperitoneally (i.p.) applications of OVA/alum followed by the intranasal challenge with OVA. The different Th1-inducing adjuvants were applied to the mice together with OVA/alum i.p. during the OVA-sensitization period and, subsequently, different parameters of allergic immune responses were evaluated.Results All the adjuvants were effective in inhibiting the development of allergen-induced airway eosinophilia, mucous production and, with the exception of PPD, also airway hyper-reactivity, when they were applied together with OVA/alum. However, allergen-specific IgG1 and IgE serum levels were only reduced in live BCG- and PPD-treated mice. Suppression of airway eosinophilia was not observed in IFN-γ- or IL-12-deficient mice (hk-BCG, CpG-ODN and PPD). Interestingly, live BCG was still able to suppress allergen-induced Th2 responses in the absence of either IFN-γ or IL-12. When mice vaccinated with the different adjuvants together with OVA/alum were subjected to a second period of OVA/alum immunization, only live and hk-BCG were able to efficiently suppress the development of airway inflammation. This effect could be adoptively transferred by splenic CD4+ T cells.Conclusions Taken together our data suggest that live BCG〉hk-BCG〉CpG-ODN 〉PPD are effective in suppressing allergen-induced Th2 responses. The degree of suppression and the component of the Th2 response affected (airway inflammation vs. the production of allergen-specific IgE and IgG1) were dependent upon the adjuvant used and how it was applied. Our results contribute to the design of novel vaccines protecting humans from developing allergic disorders.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02287.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 402 (1999), S. 769-777 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/47134
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Electron impact induced fragmentation of aromatic N-alkoxy-imines I. Ring closure in (M-CH2O)+• ions by intramolecular aromatic substitution (1997)
    Springer
    Monatshefte für Chemie 128 (1997), S. 659-673 
    Details
    ISSN: 1434-4475
    Schlagwort(e): N-Alkoxybenzaldimines ; Electron impact ionization ; Distonic ions ; Ring closure ; Homolytic aromatic substitution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung N-Butoxy- und N-Propoxy-imine auso-,m-, undp-substituierten Benzaldehyden (X=F, Cl, Br, I) zersetzen sich unter Elektronenbeschuß durch Verlust von C n H2n zu den entsprechenden Aldoximen. In einer Konkurrenzreaktion entstehen über 1,5-distonische Radikalkationen durch Abspaltung von CH2O 1,3-distonische Ionen, die im Verlauf einer homolytischen aromatischen Substitution H2022 und/oder ein Halogenatom eliminieren, wodurch cyclische (M-CH2O-H•)+-oder (M-CH2O-X •)+-Ionen gebildet werden.
    Notizen: Summary N-Butoxy- and N-propoxy-imines derived fromo-,m-, andp-substituted benzaldehydes (X = F, Cl, Br, I) decompose upon electron impact to the respective aldoximes by loss of C n H2n and competitivelyvia 1,5-distonic radical cations by loss of CH2O to 1,3-distonic ions which eliminate H• and/or a halogen atom in the course of homolytic aromatic substitution, giving rise to cyclic (M-CH2O-H•)+ or (M-CH2O-X •)+ ions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00807597
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Imaging of self-generated multifilamentary current patterns in GaAs (1988)
    Springer
    The European physical journal 71 (1988), S. 171-178 
    Details
    ISSN: 1434-6036
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Two-dimensional imaging of current filament patterns generated in homogeneousn-type GaAs during avalanche breakdown at low temperatures is reported. The self-generated formation and subsequent growth behavior of distinct single- and multifilament configurations could globally be visualized by means of a scanning electron microscope equipped with a liquid-helium stage. From local conductivity measurements in the smallest possible filaments (typical diameter of about 10 μm) carrier mobilities as high as about 4·106 cm2/Vs at 4.2 K were estimated. Such high-mobility filament channels may become interesting for applications in ultrafast electronic circuits.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01312786
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 6
    Digitale Medien
    Digitale Medien
    Experimental contribution to the dithranol-brown problem (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 153-155 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Dithranol ; Metabolization in epidermis ; Dithranol-Brown ; Copper
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00414118
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 7
    Digitale Medien
    Digitale Medien
    Classification of current instabilities during low-temperature breakdown in germanium (1989)
    Springer
    Applied physics 48 (1989), S. 155-160 
    Details
    ISSN: 1432-0630
    Schlagwort(e): 05.45.+b ; 72.20.Ht ; 72.70.+m
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract We present experimental investigations on the spatio-temporal nonlinear current flow in the post-breakdown regime of p-germanium at liquid-helium temperatures. The basic nonlinear effects are characterized in terms of the underlying semiconductor physics, taking into account the influence of different experimental parameters.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01141278
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 8
    Digitale Medien
    Digitale Medien
    Detection of reprocessing activities through stable isotope measurements of atmospheric noble gases (1997)
    Springer
    Fresenius' journal of analytical chemistry 358 (1997), S. 533-535 
    Details
    ISSN: 1432-1130
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Noble gas stable isotope abundance measurements may provide a tool for detecting reprocessing activities of nuclear fuels. An approach has been made by carrying out blending calculations of released fission xenon and krypton in air using the Isotope Mixture Programs which have been developed at the IRMM. After having obtained a reliable approximation to the expected range of the isotope ratios in the blends and the respective detection limit thereof through these calculations, the potential application of ultra-accurate measurements of the isotopic composition of anthropogenic and atmospheric noble gases is taken into consideration. Also the important role of radiometric measurements of 85Kr and 133Xe for the detection of nuclear fuel reprocessing is taken into account. The information provided by such activity measurements is limited, therefore a method to calculate the initial isotopic composition of released fission noble gases, through measuring of their atmospheric mixing ratio, is presented and discussed. Highly accurate stable isotopic measurements of atmospheric noble gases might provide more detailed information on the “history” of the reprocessed nuclear fuel. Therefore they could serve, in combination with radiometric detection techniques, as an excellent tool for the identification of reprocessing activities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002160050461
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 9
    Digitale Medien
    Digitale Medien
    Preparation and certification of new thorium isotopic reference materials (1998)
    Springer
    Fresenius' journal of analytical chemistry 361 (1998), S. 400-403 
    Details
    ISSN: 1432-1130
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Preparation of two Isotopic Reference Materials of thorium has been performed, starting from highly enriched 232Th (99.99%) and 230Th (99.8%). After full characterization (chemical and isotopic) of these purified base materials the thorium nitrate was transformed to thorium dioxide. Accurately weighed amounts of the two isotopes in the dioxide form were subsequently dissolved in nitric acid and resulted in solutions with amount ratios n(230Th)/n(232Th) close to 10–5 (IRMM-035) and 3 · 10–6 (IRMM-036). These gravimetrically prepared ratios were finally verified by means of Thermal Ionization Mass Spectrometry (TIMS). The purpose of the Reference Materials is to calibrate thorium isotope amount ratio measurements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002160050914
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 10
    Digitale Medien
    Digitale Medien
    Gibt es eine gesicherte Immuntherapie bei der Sepsis? (1997)
    Springer
    Der Internist 38 (1997), S. 541-552 
    Details
    ISSN: 1432-1289
    Schlagwort(e): Schlüsselwörter Schock ; septischer ; Schock ; Therapie ; Endotoxine ; Zytokine ; Immunmodulation ; Therapie ; Immunmodulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Zum Thema Der klinische Verlauf des septischen Schocks, der auch heute noch mit einer extremen Letalität von 40–80% einhergeht, läßt sich im pathogenetischen Verlauf vereinfachend in 3 Stadien einteilen: (1.) Einschwemmung von Keimen und Toxinen, (2.) Zytokinfreisetzung und (3.) Aktivierung sekundärer Mediatorsysteme und damit verbundene Mikrozirkulationsstörung sowie Zellschädigung. Daß die Sepsisinzidenz ständig zunimmt, wird erklärt mit der immer weiter verbreiteten Keimeinschwemmung durch invasivere therapeutische und diagnostische Maßnahmen, mit der steigenden Anzahl von chronisch kranken Patienten und mit der zunehmenden Verbreitung immunsuppressiver Behandlungsformen. Die bessere Beherrschung der initialen Sepsisphase durch organ- und kreislaufsupportive Maßnahmen läßt mehr Patienten das kritische Frühstadium überstehen und in ein protrahiertes Bild übergehen – das „chronische Sepsissyndrom”. In dieser ausführlichen Übersicht werden eingehend und kritisch die immunmodulierenden Therapiekonzepte dargelegt, mittels derer man den Sepsisverlauf mit der kaskadenartigen Ausschüttung von Endotoxin, Zytokinen und anderen Mediatorsubstanzen zu beeinflussen versucht. Die vorgelegten Ergebnisse, ob in der klinischen Anwendung erfolgreich oder nicht, tragen viel zum Verständnis des Pathogenese des septischen Schocks bei.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00002644
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...