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  • 11
    Electronic Resource
    Electronic Resource
    The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons (1995)
    [s.l.] : Nature Publishing Group
    Nature genetics 10 (1995), S. 77-83 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We have identified a strong candidate cDNA for the mouse reeler gene. This 5 kb transcript encodes a 99.4 kD protein consisting of 881 amino acids and possessing two EGF–like motifs. We assayed two independent mutant alleles — ‘Jackson reeler’, which has a deletion of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0595-77
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  • 12
    Electronic Resource
    Electronic Resource
    Lipid composition of a freeze-tolerant yeast, Torulaspora delbureckii, and its freeze-sensitive mutant (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 167-171 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  We analyzed the lipid compositions of a freeze-tolerant strain of yeast Torulaspora delbrueckii D2-4 and its freeze-sensitive mutant 60B3 to clarify the relationship between the lipid composition and freeze tolerance of yeast. The total lipid content of D2-4 was similar to that of 60B3, whereas the content of phospholipids and neutral lipids was different from those of 60B3. The molar ratio of sterol to phospholipid in D2-4 was 60% of that in 60B3. The analysis of lipid components indicated that D2-4 contained larger amounts of phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol, but smaller amounts of triglyceride as compared to 60B3. These results suggest that the plasma membrane of freeze-tolerant strain D2-4 may have a higher fluidity than that of freeze-sensitive strain 60B3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050536
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  • 13
    Electronic Resource
    Electronic Resource
    Lipid composition of a freeze-tolerant yeast, Torulaspora delbureckii, and its freeze-sensitive mutant (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 167-171 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract We analyzed the lipid compositions of a freeze-tolerant strain of yeast Torulaspora delbrueckii D2-4 and its freeze-sensitive mutant 60B3 to clarify the relationship between the lipid composition and freeze tolerance of yeast. The total lipid content of D2-4 was similar to that of 60B3, whereas the content of phospholipids and neutral lipids was different from those of 60B3. The molar ratio of sterol to phospholipid in D2-4 was 60% of that in 60B3. The analysis of lipid components indicated that D2-4 contained larger amounts of phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol, but smaller amounts of triglyceride as compared to 60B3. These results suggest that the plasma membrane of freeze-tolerant strain D2-4 may have a higher fluidity than that of freeze-sensitive strain 60B3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164497
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  • 14
    Electronic Resource
    Electronic Resource
    Properties of a cold-active protease from psychrotrophic Flavobacterium balustinum P104 (1998)
    Springer
    Applied microbiology and biotechnology 50 (1998), S. 669-675 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Protease activity was detected in the culture medium of Flavobacterium balustinum P104 grown at 10 °C, which was isolated from salmon (Oncorhynchus keta) intestine. The enzyme, designated as CP-70 protease, was purified to homogeneity from the culture broth by ion exchange and gel filtration chromatographyies. The molecular mass of the protease was 70 kDa, and its isoelectric point was close to 3.5. Maximal activity toward azocasein was observed at 40 °C and from pH 7.0 to 9.0. The activity was strongly inhibited by phenylmethylsulfonyl fluoride, suggesting that the enzyme is a serine protease. The n-terminal amino acid sequence was Asp-Thr-Arg-Gln-Leu-Leu-Asn-Ala-Asn-Ser-Asp-Leu-Leu-Asn-Thr-Thr-Gly-Asn-Val-Thr-Gly-Leu-Thr-Gly-Ala-Phe-Asn-Gly-Glu-Asn. A search through the database for sequence homology yielded no significant match. The initial cleavage sites for oxidized insulin B-chain were found to be the Glu13-Ala14 and Phe24-Phe25 bonds. The result of the cleavage pattern of oxidized insulin B-chain suggests that CP-70 protease has a broader specificity than the other cold-active proteases against the peptide substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530051349
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  • 15
    Electronic Resource
    Electronic Resource
    Sequence determination and phylogenetic analysis of RNA-dependent RNA polymerase (RdRp) of the porcine enterovirus 1 (PEV-1) Talfan strain (1999)
    Springer
    Archives of virology 144 (1999), S. 1845-1852 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  The nucleotide sequence of the region including the RNA-dependent RNA polymerase (RdRp) of the porcine enterovirus 1 (PEV-1) Talfan strain was determined. Amino acid identities of Talfan RdRp with those of other picornaviruses were significantly lower than those seen among the viruses of the same genus of picornaviruses. The phylogenetic analysis of RdRp indicated that picornaviruses were divided into 8 clusters, in which Talfan was genetically distinct from other picornaviruses in contrast to the current taxonomy. In this study, we propose that PEV-1 Talfan be regarded as a new genus for the family Picorna- viridae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050709
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  • 16
    Electronic Resource
    Electronic Resource
    Abnormal cell divisions in leaf primordia caused by the expression of the rice homeobox geneOSH1 lead to altered morphology of leaves in transgenic tobacco (1996)
    Springer
    Molecular genetics and genomics 251 (1996), S. 13-22 
    Details
    ISSN: 1617-4623
    Keywords: Homeobox gene ; In situ hybridization ; Leaf morphology ; Transgenic tobacco
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Transgenic tobacco plants were generated carrying a rice homeobox gene,OSH1, controlled by the promoter of a gene encoding a tobacco pathogenesis-related protein (PR1a). These lines were morphologically abnormal, with wrinkled and/or lobed leaves. Histological analysis of shoot apex primordia indicated arrest of lateral leaf blade expansion, often resulting in asymmetric and anisotropic growth of leaf blades. Other notable abnormalities included abnormal or arrested development of leaf lateral veins. Interestingly,OSH1 expression was undetectable in mature leaves with the aberrant morphological features. Thus,OSH1 expression in mature leaves is not necessary for abnormal leaf development. Northern blot and in situ hybridization analyses indicate thatPR1a-OSH1 is expressed only in the shoot apical meristem and in very young leaf primordia. Therefore, the aberrant morphological features are an indirect consequence of ectopicOSH1 gene expression. The only abnormality observed in tissues expressing the transgene was periclinal (rather than anticlinal) division in mesophyll cells during leaf blade initiation. This generates thicker leaf blades and disrupts the mesophyll cell layers, from which vascular tissues differentiate. TheOSH1 product appears to affect the mechanism controlling the orientation of the plane of cell division, resulting in abnormal periclinal division of mesophyll cell, which in turn results in the gross morphological abnormalities observed in the transgenic lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02174339
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  • 17
    Electronic Resource
    Electronic Resource
    Phase relation and properties of oxynitride glasses in the Si3N4-Yb2O3-SiO2 system (1996)
    Springer
    Journal of materials science 15 (1996), S. 1271-1272 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274398
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  • 18
    Electronic Resource
    Electronic Resource
    Evaluation of an automated DNA sequencing system developed in RIKEN (1995)
    Springer
    Bioprocess engineering 13 (1995), S. 223-229 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  For the advancement of Human Genome Project, we have developed an automated DNA sequencing system ‘HUGA-I.’ It is composed of several automated instruments and transfer robots connecting them. In this paper we describe the results of the performance evaluation test of HUGA-I. Although some of the system units showed good performances, the total performance of the HUGA-I was about 1/6 of the designed value. By revealing principal reasons of this poor performance, we would like to contribute to the automation in genome analysis, particularly in human genome analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417632
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  • 19
    Electronic Resource
    Electronic Resource
    Formation mechanism of anomalous “golf ball-like” composite polymer particles by seeded emulsion polymerization (1996)
    Springer
    Colloid & polymer science 274 (1996), S. 520-524 
    Details
    ISSN: 1435-1536
    Keywords: Composite polymer particle ; emulsion polymerization ; morphology ; anomalous shape ; phase separation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Recently, the authors found that anomalous polystyrene/polybutyl acrylate composite particles, whose surfaces had many dents, were produced by emulsifier-free seeded emulsion polymerization of butyl acrylate with polystyrene seed particles. Such a particle was named a “golf ball-like” particle. In this article, the morphology and the formation mechanism of the golf ball-like composite polymer particles were studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00655226
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  • 20
    Electronic Resource
    Electronic Resource
    Age-related changes in the compound action potentials of the eighth nerve in guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 145-149 
    Details
    ISSN: 1434-4726
    Keywords: Eighth nerve compound action potential ; Aging effects ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The eighth nerve compound action potential (CAP) in 95 guinea pigs was measured using click stimuli to investigate age-related changes in their neural auditory thresholds. The animals were separated into three groups: group A (n = 43, 86 ears; 2–4 months old); group B (n = 29; 58 ears, 13–15 months old); and group C (n = 23; 46 ears, 23–25 months old). With increasing age, a gradual elevation of CAP thresholds was clearly seen among the three groups. The negative peak (N1) latencies of the CAP were prolonged, and the N1 amplitudes of the CAP decreased. There were significant differences in N1 latencies among the three groups and in N1 amplitudes between groups A and B, and between groups A and C. However, the rate of decline of the thresholds as well as the input-output function curves of the CAP varied in some of the oldest animals, suggesting that there were some individual differences in degenerative aging processes of the auditory system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471279
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