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  • 2005-2009  (3)
  • 1990-1994  (21)
  • 1975-1979  (15)
  • 1960-1964  (6)
  • 11
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 153-154 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Four strains of A. tumefaciens were examined. Two strains, IIBV7 and C-58, are virulent and have been shown to harbour a large plasmid which is associated in some way with virulence8. The other two strains IIBNV6 and NT1, are avirulent and do not contain the plasmid. Strains C-58 and NT1 are very ...
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 357 (1992), S. 187-187 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - I was surprised that Nature1 thought it necessary to make something of a conundrum of the fact that Charles Darwin was a strong supporter of physiology and recognized the need for experiment on animals. In 1875, largely in response to a vigorous antivivisection-ist campaign, the Cardwell ...
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 438 (2005), S. 991-993 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gamma-ray bursts (GRBs) divide into two classes: ‘long’, which typically have initial durations of T90 〉 2 s, and ‘short’, with durations of T90 〈 2 s (where T90 is the time to detect 90% of the observed fluence). Long ...
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gamma-ray bursts (GRBs) and their afterglows are the most brilliant transient events in the Universe. Both the bursts themselves and their afterglows have been predicted to be visible out to redshifts of z ≈ 20, and therefore to be powerful probes of the early Universe. The burst GRB 000131, ...
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 203 (1964), S. 872-873 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Tracings from original records illustrating the modification of the form of the action potential when anodal current (dashed line), and cathodal current (solid line) are applied during the repolarization phase. The normal course of repolarization is shown by the fine solid line. Action ...
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 701-702 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When the 'node' is stimulated by direct current there is a repetitive response. Before the first action potential a normal local potential develops, but the following action potentials arise at a level of depolarization greater than the amplitude of the first local potential. Therefore no pacemaker ...
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 187 (1960), S. 960-961 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Crimp deterioration in fine Merino and Polwarth wools in changing from normal (1) to 'doggy' (3) In changing from normal to doggy, fine and medium Merino and Polwarth wools pass through an intermediate phase with secondary waves superimposed on the normal crimp ; in strong Merino wool the ...
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 422 (1993), S. 325-331 
    ISSN: 1432-2013
    Keywords: Myocyte ; Voltage clamp ; Ionic currents ; Oximes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exposure of isolated guinea-pig ventricular myocytes to the uncharged oximes 2,3 butanedionemonoxine (BDM) and norPAM (but not by the charged PAM) results in a dose-dependent reduction of the duration of the action potential. The nifedipine-sensitive Ca current is fully inhibited by BDM (IC505.8±0.4 mM) and nor PAM but is little affected by PAM. This inhibition is unaltered by the presence of BAY K 8644 but is antagonized by isoprenaline. The effect of isoprenaline is more pronounced when the solution in the patch pipette contains the non-hydrolysable analogue of adenosine 5′-triphosphate, ATPγS (the IC50 is increased to 44.0±5.2 mM). A hastening of the inactivation of the L-type Ca current persists when either 10 mM 1,2-bis(2-aminophenoxy)-ethane-N, N, N′, N-tetraacetic acid (BAPTA) or 3 mM ATPγS is present in the pipette solution or when BAY K 8644 or isoprenaline are present in the bathing fluid. These results suggest that the inhibition of the Ca current is due to the phosphatase-like activity of the oximes but differs in some respects from previous work where a reduced level of phosphorylation is achieved by the introduction of protein kinase inhibitors or protein phosphatases into the sarcoplasm in guinea-pig myocytes. These differences could be explained if Ca channel availability is regulated by at least two sites of cAMP-dependent phosphorylation with oximes able to rapidly dephosphorylate both sites, while one of these sites is not readily dephosphorylated by the endogenous phosphatases.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1432-2013
    Keywords: Myocyte ; Intracellular ions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method for the manufacture of ion-sensitive micro-electrodes, which can be readily used with small single cells, is described in detail. A glass pipette with a tip size of 1 μm, essentially similar to those used as suction electrodes in whole-cell recording, when silanized and with its tip filled with a suitable ion-sensitive resin, producesan ion-sensitive electrode with fast electrical and chemical response times. These electrodes can be applied to the cell membrane of isolated myocytes and penetration achieved without cell damage, by the application of suction. For the estimation of intracellular ionic activities they can be used in conjunction with a separate conventional KCl-filled micro-electrode or a suction voltage electrode. The technique is illustrated by the measurement of intracellular Na+, Ca2+ and pH. It is possible that these electrodes can also be used to measure local changes in ionic activity in restricted areas.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Planta 131 (1976), S. 271-274 
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Quantitative trace-enrichment of cytokinins from a plant source (xylem sap from the Douglasfir, Pseudotsuga menziesii (Mirb.) Franco) has been achieved by adsorption onto octadecyl-silica columns followed by elution with ethanol. Adsorption is rapid and efficient and allows complete recovery of cytokinins at the nanomolar level. Douglas-fir sap contains at least four compounds having cytokinin activity, one of which co-elutes with zeatin and another with ribosylzeatin.
    Type of Medium: Electronic Resource
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