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  • 2005-2009  (1)
  • 1980-1984  (4)
  • 1960-1964  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Overexpression of tumour necrosis factor-α-converting enzyme in psoriasis (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background  Tumour necrosis factor (TNF)-α-converting enzyme (TACE) is a metalloproteinase-disintegrin that releases soluble TNF-α from cells by cleaving within the extracellular domain of membrane-bound pro-TNF-α. It was proposed that TNF-α is involved in the pathogenesis of psoriasis, and it is therefore suggested that TACE has important roles in psoriasis. However, it is unclear whether TACE is expressed in psoriatic tissue.Objectives  To clarify whether TACE is expressed in psoriatic lesions and whether expression levels of TACE mRNA are increased in lesional compared with nonlesional psoriatic skin.Methods  Skin biopsies were obtained from patients with psoriasis. We examined the expression of TACE in psoriatic tissues using a novel real-time quantitative reverse transcriptase–polymerase chain reaction method and immunohistochemical analysis.Results  There was a significant rise in the level of TACE mRNA expression in lesional psoriatic skin compared with nonlesional skin in all patients. There was a statistically significant rise in the level of TACE mRNA expression in lesional psoriatic skin compared with nonlesional skin (mean ± SD TACE/glyceraldehyde-3-phosphate dehydrogenase ratio 0·031 ± 0·012 vs. 0·009 ± 0·002, P 〈 0·05). In lesional psoriatic skin, immunostaining with anti-TACE antibody was present throughout all layers of the epidermis. TACE immunostaining was found in the cytoplasm of keratinocytes. There was staining associated with blood vessels in the papillary dermis and perivascular inflammatory cells. In particular, mast cells showed strong staining. They contained numerous granules that were stained for TACE in the cytoplasm.Conclusions  The findings of the present study suggest that elevation of TACE mRNA in psoriatic lesions is due to many cells, particularly mast cells, that function in lesional psoriatic skin as an important source of TNF-α and other cytokines.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06440.x
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  • 2
    Digitale Medien
    Digitale Medien
    Electrophoretic Behaviour of Rabbit Serum Amylase (1963)
    [s.l.] : Nature Publishing Group
    Nature 200 (1963), S. 572-573 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Aliquots of 60 µl. of fresh serum from 7 rabbits were placed in duplicate on Whatman 3MM filter paper strips moistened with veronal buffer (pH. 8.6, ionic strength 0.075). Electrophoretic separations were performed in a horizontal cell at a constant potential of 80 V for 16 h. One ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/200572a0
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  • 3
    Digitale Medien
    Digitale Medien
    A defective enzyme in hyperphenylalaninaemia due to biopterin deficiency (1983)
    Springer
    Journal of inherited metabolic disease 6 (1983), S. 127-128 
    Details
    ISSN: 1573-2665
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01800745
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  • 4
    Digitale Medien
    Digitale Medien
    Spectroscopy of atomlike mesonsQ $$\bar q$$ in the dirac equation with scalar confining potential (1981)
    Springer
    The European physical journal 9 (1981), S. 213-220 
    Details
    ISSN: 1434-6052
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Spectroscopy of atomlike mesons composed of one heavy quarkQ and one light quark $$\bar q$$ is studied in the Dirac equation with (i) scalar power law potential, (ii) scalar logarithmic potential and (iii) Coulomb plus scalar linear potential. It is found that the potentialr 0.1 gives an excellent fit toD, F andB mesons together with Ψ and Υ families treated in the nonrelativistic theory, and that the light quark masses in atomlike mesons are very close to the current quark masses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01410660
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  • 5
    Digitale Medien
    Digitale Medien
    Spectroscopy of charmed baryons (1983)
    Springer
    The European physical journal 17 (1983), S. 219-227 
    Details
    ISSN: 1434-6052
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract An atomlike baryon composed of one heavy quark and two light quarks is studied in a similar way to the Breit theory of a helium atom. Spectroscopy of charmed baryons is given for the vector Coulomb plus scalar linear confining potential.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578148
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  • 6
    Digitale Medien
    Digitale Medien
    Spectroscopy of $$Q\bar Qg$$ hybrid mesons (1984)
    Springer
    The European physical journal 24 (1984), S. 143-149 
    Details
    ISSN: 1434-6052
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Hybrid mesons composed of a quark, an antiquark, and a gluon are studied in the case of heavy quarks. Their masses are calculated with the potential model which can interpret heavy quarkonium spectroscopy. The ground state of the hybrid mesons $$c\bar cg$$ and $$b\bar bg$$ is found to be almost spherically symmetric, whereas that of $$t\bar tg$$ is two-centered as anH 2 + molecule. The $$b\bar bg\left[ {t\bar tg} \right]$$ ground state turns out to have a mass below the $$B\bar B\left[ {T\bar T} \right]$$ threshold. The excited states contain 0−−, 1−+ exotic states and 1−− states which may be examined bye + e − colliders.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01571718
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