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  • 2005-2009  (3)
  • 1955-1959  (1)
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  • 1
    ISSN: 1474-8673
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Chemistry and Pharmacology , Medicine
    Notes: 1 This study evaluated the inhibitory action of apigenin-7-O-β-d-glucuronopyranoside (AGC), apigenin, and omeprazole on reflux oesophagitis and gastritis in rats. AGC was isolated from Clerodendron trichotomum leaves. 2 Oesophagitis and gastritis were induced by surgical procedure and the administration of indomethacin, respectively. The intraduodenal (i.d.) administration of AGC decreased the volume of gastric juice and increased the gastric pH compared with apigenin and omeprazole. The acid output was more inhibited by AGC in a dose-dependent manner than by apigenin and omeprazole. Compared with apigenin and omeprazole, AGC significantly decreased the size of gastric lesions, which were induced by exposure of the gastric mucosa to indomethacin. 3 Malondialdehyde (MDA) content, which is the end product of lipid peroxidation, was increased significantly after the induction of reflux oesophagitis. The MDA content was decreased by AGC (i.d. 3 mg kg−1), but not by either apigenin or omeprazole. This suggests that AGC has an antioxidative effect. In the oesophagitis group, the mucosal levels of glutathione (GSH) were significantly lower than that in the normal group. However, the GSH levels were preserved after administering the AGC, suggesting that AGC possesses scavenging activity. 4 In summary, AGC is more potent than apigenin and omeprazole at inhibiting reflux oesophagitis and gastritis and may therefore be a promising drug for their treatment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 31 (Nov. 2007), p. 135-137 
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Programmable metallization cell (PMC) memory is based on the electrochemical control ofnanoscale quantities of metal in thin films of solid electrolyte. We investigate the nature of thin filmsformed by the photo-dissolution of Ag into Ge-Se-Te glasses for use in programmable metallizationcell devices. Glassy alloys of a-Ge25Se75-xTex(x = 0, 25) are prepared by well known melt-quenchingtechnique. Thin films of a-Ge25Se75-xTex(x = 0, 25) glassy alloys are evaporated by vacuumevaporation technique at ~10-6 torr on glass substrate at room temperature. Optical properties in thisstudy concerns photo-diffusion of Ag on Ag-doped Ge-Se-Te electrolytes. With these promisingproperties, the composition a-Ge25Se75-xTex(x = 0, 25) is recommended as a potential candidate forPMC-RAM
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Clinical and experimental medicine 131 (1959), S. 238-245 
    ISSN: 1591-9528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Vergleichende Untersuchungen an Ratten, die 4 Monate hindurch in einer Tiergruppe statt Trinkwasser mit 15%igem Alkohol, in einer 2. Gruppe mit einer cirrhogenen Diät (nachDaft) und in einer weiteren Gruppe schließlich mit einer cirrhogenen Diät und Alkohol statt Trinkwasser ernährt und dann für 3 Wochen auf Normalkost gesetzt worden waren, hinsichtlich Körpergewicht, Verhalten der Serumeiweißkörper und histologischem Befund in Leber und Milz. Die mit Alkohol aufgezogenen Tiere ließen nur bei den zu Versuchsbeginn älteren Tieren einen Schaden erkennen, der nach Vollkostperiode voll wieder ausgeglichen war. Die mit Eiweißmangeldiät ernährten Tiere zeigten nach der Kostumstellung einen steilen Gewichtsanstieg. Bei den am stärksten geschädigten Tieren der mit Mangeldiät und Alkohol aufgezogenen Gruppe sowie bei einem Tier, das bei alleiniger Mangeldiät eine Lebercirrhose entwickelte, kam es zu einer statistisch gesicherten Hypalbuminämie und Hyper-β-Globulinämie, die die Periode des Gewichtsanstieges überdauert. Auch die feingeweblichen Veränderungen, die durch vermehrte Fetteinlagerung und Faservermehrung in der Leber sowie durch Faserzunahme und Eisenschwund in der Milz gekennzeichnet sind, überdauern die Periode der Gewichtszunahme. Es finden sich charakteristische Unterschiede hinsichtlich Fettmenge und Fettverteilung in der Leber zwischen den nur mangelernährten und der durch Mangeldiät und Alkoholgaben geschädigten Tiergruppe. Bei Eiweißmangeldiät stellt zusätzliche Alkoholzufuhr eine erheblich potenzierende Noxe dar.
    Type of Medium: Electronic Resource
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