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  • 2000-2004  (4)
  • 1995-1999  (15)
  • 1970-1974  (21)
  • 1960-1964  (5)
  • 1950-1954  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Photoisomerizations in the α-Tropolone Series: The Mechanistic Path of the α-Tropolone Methyl Ether to Methyl 4-Oxo-2-cyclopentenylacetate Conversion1 (1963)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2616-2621 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00900a021
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. XXV. Carbon-13 nuclear magnetic resonance spectral analysis of tobramycin and related antibiotics (1974)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 96 (1974), S. 3300-3305 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00817a045
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CARBOHYDRATE-MODULATED GENE EXPRESSION IN PLANTS (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Plant Physiology and Plant Molecular Biology 47 (1996), S. 509-540 
    Details
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Plant gene responses to changing carbohydrate status can vary markedly. Some genes are induced, some are repressed, and others are minimally affected. As in microorganisms, sugar-sensitive plant genes are part of an ancient system of cellular adjustment to critical nutrient availability. However, in multicellular plants, sugar-regulated expression also provides a mechanism for control of resource distribution among tissues and organs. Carbohydrate depletion upregulates genes for photosynthesis, remobilization, and export, while decreasing mRNAs for storage and utilization. Abundant sugar levels exert opposite effects through a combination of gene repression and induction. Long-term changes in metabolic activity, resource partitioning, and plant form result. Sensitivity of carbohydrate-responsive gene expression to environmental and developmental signals further enhances its potential to aid acclimation. The review addresses the above from molecular to whole-plant levels and considers emerging models for sensing and transducing carbohydrate signals to responsive genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.arplant.47.1.509
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    Paper (German National Licenses)
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  • 4
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    Messias und Sündenvergebung in Jesaja 53-Targum (1972)
    Leiden : Periodicals Archive Online (PAO)
    Journal for the Study of Judaism in the Persian, Hellenistic, and Roman Period. 3 (1972) 117-148 
    Details
    ISSN: 0047-2212
    Topics: History , Theology and Religious Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:v021-1972-003-00-000008
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  • 5
    Electronic Resource
    Electronic Resource
    Alosetron repeat dose pharmacokinetics, effects on enzyme activities, and influence of demographic factors (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To assess the pharmacokinetics of alosetron, its effect on in vivo enzyme activities, and influence of demographic factors during repeated dosing.Methods : Thirty healthy men and women received 1 mg oral alosetron twice-daily for 29.5 days and a single oral dose of a metabolic probe cocktail before and on the last day of alosetron dosing. Serum alosetron concentrations were measured on days 1, 8, 15, 22 and 29. Probe-substrate and metabolite concentrations were measured after each cocktail dose.Results : Alosetron accumulation in serum was negligible. Exposure to alosetron did not alter probe-metabolite/substrate ratios associated with CYP2C19, 2E1, 2C9, or 3A4 activity, but modestly decreased those associated with CYP1A2 and N-acetyltransferase activity. Systemic exposure to alosetron was higher in women, positively correlated with age and body mass index, and negatively correlated with CYP1A2 activity. Incidence of constipation was higher in women, but not associated with alosetron concentration.Conclusions : Single dose data can reliably predict the pharmacokinetics of alosetron after repeated doses. Alosetron exhibits limited potential for inhibition of cytochrome P450-mediated metabolism. Interindividual differences in alosetron pharmacokinetics associated with demographic factors may be related to strong dependence on metabolism by CYP1A2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02031.x
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  • 6
    Electronic Resource
    Electronic Resource
    The safety of ranitidine in over a decade of use (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Ranitidine hydrochloride (Zantac) is one of the most extensively studied and widely used drugs of all time. This has provided an excellent opportunity to define its safety profile. Methods: Data from 189 controlled clinical trials in which more than 26000 patients received daily doses of ranitidine for 4 weeks or more were reviewed. More than 80% of patients were treated with up to 300 mg ranitidine daily; the remaining patients received doses of up to 1200 mg daily. Eighty-seven trials were placebo controlled. Analyses of post-marketing surveillance and a database of all spontaneously reported adverse events were also evaluated. Results: Overall in the clinical trial programme adverse events were reported by 20% of those receiving ranitidine compared with 27% of those receiving placebo. The pattern of events was similar in all treatment groups with no evidence of dose-related toxicity in regimens encompassing an eightfold range of therapeutic doses. Similarly in a programme of studies designed to evaluate a dose of ranitidine of 75  mg for non-prescription (over-the-counter) use in the treatment of heartburn, ranitidine was not associated with an adverse event profile distinct from that of placebo. Analysis of spontaneously reported adverse event data allowed identification of rare idiosyncratic events. Conclusions: Review of data from a large population of controlled clinical trials with analyses of postmarketing surveillance studies and spontaneously reported adverse events confirmed the excellent safety profile of ranitidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.136312000.x
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  • 7
    Electronic Resource
    Electronic Resource
    Pion absorption reactions on N, Ar and Xe (2000)
    Springer
    The European physical journal 9 (2000), S. 537-552 
    Details
    ISSN: 1434-601X
    Keywords: PACS. 25.80.Ls Pion inclusive scettering and absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The absorption of π+ on Ar was studied at pion energies of 70, 118, 162, 239 and 330MeV, and on N and Xe at 239MeV. Twenty-six absorption reaction channels with at least two energetic charged particles in the final state have been evaluated. Partial cross-sections have been determined according to the number of protons, neutrons and deuterons in the final state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500070010
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  • 8
    Electronic Resource
    Electronic Resource
    Zum Mechanismus der Magnetisierungssprünge (1951)
    Springer
    The European physical journal 130 (1951), S. 409-414 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung An Proben mit Vorzugsrichtung der Magnetisierung wird festgestellt, da\ ein Hilfsfeld von höherer Frequenz die Auslösung und den Ablauf der Magnetisierungssprünge fördert und damit — bei gegebenen Werten des Hauptfeldes — eine Erhöhung des Wertes der Sättigungsmagnetisierung und der Remanenz bewirkt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01328431
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  • 9
    Electronic Resource
    Electronic Resource
    Die Anomalie der galvano- und thermomagnetischen Transversaleffekte (1952)
    Springer
    The European physical journal 131 (1952), S. 143-155 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung In Fortführung der AnsÄtze von H.Fröhlich werden die Koeffizienten der vier Transversaleffekte abgeleitet, sie weisen gerade jene Kopplung der Vorzeichen auf, die sich aus den bisher bekannten Me\resultaten ergibt. Es wird ferner gezeigt, da\Ettingshausen- undNernst-Effekt als thermoelektrische SekundÄreffekte aufgefa\t werden können, die durch die Begrenzung der Versuchsstreifen in LÄngsrichtung entstehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01332001
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  • 10
    Electronic Resource
    Electronic Resource
    Extrarenal actions of aldosterone antagonists in guinea pigs (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 9-18 
    Details
    ISSN: 1432-1912
    Keywords: Aldosterone Antagonists ; β-Methyl-Digoxin ; Guinea Pigs ; Potassium ; Cardiac Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of aldosterone antagonists on the cardiotoxicity of β-methyl-digoxin in guinea pigs were investigated in vivo and in vitro. 1. Three days of pretreatment with spironolactone influenced neither plasma concentrations, urinary output and tissue distribution of radioactivity after intravenous injection of β-methyl-digoxin nor the pattern of lipid soluble metabolites in the urine. 2. Spironolactone injected intraduodenally 1 h before the infusion of β-methyl-digoxin decreased the cardiotoxicity of the latter if hypokalemia was reduced or prevented by giving 0.4–1.0 mEq/kg KCl 1 h before β-methyl-digoxin. 3. Three days of pretreatment with canrenoate-K decreased the cardiotoxicity of β-methyl-digoxin in vivo without the administration of KCl. 4. Isolated hearts from guinea pigs pretreated with canrenoate-K for 3 days tolerated the perfusion with toxic concentrations of β-methyl-digoxin better than those from controls although the rate of potassium extrusion from the heart was not decreased. 5. The addition of canrenone to the fluid perfusing isolated hearts decreased the potassium extrusion produced by and the toxicity of β-methyl-digoxin. The results suggest that the decreased glycoside toxicity is due to the stimulation of inward transport of potassium by aldosterone-antagonists described in the preceding paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502063
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