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  • 1
    Electronic Resource
    Electronic Resource
    Renormalization effects of bath-induced vibronic population transfer on stationary and time-resolved resonant light scattering spectra from molecules (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 126-135 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Renormalization effects of the bath-induced vibronic population transfer on resonant light scattering (RLS) from molecules in condensed phases are theoretically studied based on the Markoffian master equation approach. By using the double space diagram technique, the self-energy originated from the bath-induced vibronic population transfer is analytically solved, and the analytic expressions for the intensities both of the stationary and of the time-resolved RLS spectra are derived. The renormalization effect is analyzed in terms of dimensionless molecular parameters, and model calculations are also performed to confirm theoretical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459720
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  • 2
    Electronic Resource
    Electronic Resource
    Band structure of stationary emission spectra from a three-level molecule pumped by strong radiation fields (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 3012-3032 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A theory of the emission spectrum from a multilevel molecular system pumped by strong resonant radiation fields based on the double space theory of the density matrix is developed. We are especially concerned with a three-level, one-laser system, and a three-level, two-laser system. It is shown that the band structure cannot always be estimated by the energy level structure of the dressed states. In fact, in both model systems, triplet structures of the emission spectra can be observed in the case where the magnitude of the molecule-field interaction is larger than that of the detuning. The characteristic features of the band structure are interpreted in terms of the dressed state picture based on analytically solvable models. Several numerical calculations are performed to show how the multiplet band structure in the emission spectrum is influenced by the detuning and the power of the pump field(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458888
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  • 3
    Electronic Resource
    Electronic Resource
    Locally designed pulse shaping for selective preparation of enantiomers from their racemate (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 1575-1581 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present a method for the design of laser fields to control a selective preparation of enantiomers from their racemate. An expression for two components of the laser pulses [EX(t) and EY(t)] propagating along the Z axis is derived using a locally optimized control theory in the density operator formalism. This expression was applied to a selective preparation of (R-, L-) enantiomers from preoriented phosphinotioic acid (H2POSH) at low temperatures. The target operator was set for the populations to be localized in one side of the double-well potential. First, a simple one-dimensional model was treated. Then, a two-dimensional model in which a free rotation around the preoriented torsional axis is included was briefly considered. In the one-dimensional model, almost complete preparation of the enantiomers was obtained. The optimal electric field consists of a sequence of two linearly polarized pulses with the same phases but with different magnitudes. This means that the resultant electric field is linearly polarized with the polarization for obtaining the R-form nearly parallel to its S–H bond. The optimal electric field transfers the L-form into the R-form while suppressing the reverse process. In the two-dimensional model, the enantiomer selective preparation is controlled by a sequence of circularly polarized pulses. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1334867
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  • 4
    Electronic Resource
    Electronic Resource
    Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma? (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.00985-5.x
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  • 5
    Electronic Resource
    Electronic Resource
    Reciprocal altered expression of T-cadherin and P-cadherin in psoriasis vulgaris (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary  Background The most characteristic change in psoriasis vulgaris is markedly increased, persistent keratinocyte proliferation. The underlying mechanism of excessive epidermal growth is controversial. We previously found and reported that T-cadherin was expressed in keratinocytes and confined to the basal layer of mouse and human skin. Invasive cutaneous squamous cell carcinoma showed a loss of T-cadherin expression. Another study showed that T-cadherin was a negative growth regulator of epidermal growth factor in T-cadherin transfectant neuroblastoma cells.Objectives  To obtain insight into the role of T-cadherin in keratinocyte proliferation and to investigate further the pathogenesis of psoriasis vulgaris, we examined the expression of T-cadherin, as well as E- and P-cadherin, in psoriasis vulgaris.Methods  Four untreated active psoriatic skin samples from psoriasis vulgaris patients and four normal human skin samples from plastic surgery were collected, cryosectioned and immunohistochemically stained by antihuman T-, P- and E-cadherin antibodies. Further, the immunofluorescence intensities of T- and P-cadherin on the basal layer of the epidermis were quantitatively measured by the histogram function of LSM 510 software installed in a Zeiss laser scanning confocal microscope. The data were statistically analysed by Student's t-test.Results  It was observed that T-cadherin was weakly and discontinuously expressed on the basal layer of psoriatic skin, while it was intensively expressed on all basal keratinocytes in normal human skin. In contrast, P-cadherin was strongly expressed throughout the entire epidermal layer in psoriatic skin samples, although its expression is restricted to the basal cell layer in normal human skin. There were no obvious differences in E-cadherin expression between normal human skin and psoriatic skin. Statistical analyses showed that the immunofluorescence intensity of T-cadherin in the basal cell layer of psoriatic skin (35 ± 9·08) was significantly decreased compared with that in normal human skin (131·75 ± 3·49, P = 2·46 × 10−6). There was a significant increase (P = 0·00139) in the immunofluorescence intensity of P-cadherin in the basal layer of psoriatic skin (68·25 ± 12·13) compared with normal human skin (26 ± 4·90).Conclusions  The present study demonstrates that there is downregulation of T-cadherin expression and upregulation of P-cadherin expression in psoriatic skin, which are considered to be involved in the hyperproliferation of keratinocytes in psoriasis vulgaris.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05464.x
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  • 6
    Electronic Resource
    Electronic Resource
    The nature of Kikuchi lines in the Bragg case in reflexion high-energy electron diffraction (1975)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 31 (1975), S. 32-38 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The behaviour of the Kikuchi lines parallel to the shadow edge, which are formed under diffraction conditions in the Bragg case, is experimentally studied for zincblende (ZnS), MgO and rock salt. A line of this group generally has an asymmetric intensity profile across it. Sometimes it shows contrast reversal from an excess appearance in the central range to a defect appearance in the side ranges along the line. These peculiarities become noticeable with the increase in the glancing angle of the incident beam with the crystal surface. It is pointed out that theoretically the form of the line term in the intensity formula for Kikuchi patterns in the Bragg case differs from that in the Laue case. The variation of the line profile, including the effect of contrast reversal, takes place by the change in the intensity formula, in the ratio of the band term to the line term, depending on the scattering vector appropriate to the inelastic electron scattering involved. By assuming approximate forms for the scattering factors for Kikuchi patterns, the observed results are qualitatively explained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739475000058
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  • 7
    Electronic Resource
    Electronic Resource
    Suppressive effects of interferons on the production and release of human T-lymphotropic virus type-I (HTLV-I) (1990)
    Springer
    Archives of virology 115 (1990), S. 63-73 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of human α-, β-, or γ-interferon (IFN) on the replication and production of human T-lymphotrophic virus type-I (HTLV-I) were investigated in a human T-cell line, MT-2. Virus transmission and production estimated by syncytium formation and HTLV-I-associated reverse transcriptase (RT) activity were strongly suppressed in the presence of α- and β-IFN, but not γ-IFN. However, the expression of virus specific proteins gp46 but not p19, p24, p28, p36, and gp68 was affected with IFNs as revealed by Western blotting analysis. Electron microscopic observations showed that some of the HTLV-I particles were trapped in the intracellular vacuoles in the presence of high doses of α- or β-IFN. Continuous supply of IFNs appeared to be essential for the constant suppression of RT activity. These results suggest that α- and β-IFN do not inhibit HTLV-I gene expression strikingly but suppress processing or assembly of virus proteins and/or releasing of virions in the late phase of maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310623
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  • 8
    Electronic Resource
    Electronic Resource
    Overexpression of cyclin D1 in nonmelanocytic skin cancer (2000)
    Springer
    Virchows Archiv 436 (2000), S. 370-376 
    Details
    ISSN: 1432-2307
    Keywords: Key words Cyclin D1 ; Skin cancer ; Differentiation ; Sun exposure ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although the overexpression of cyclin D1 has been believed to play important roles in neoplastic transformation of some tumors, little is known about the function of cyclin D1 protein in carcinogenesis in human skin. A total of 307 patients with nonmelanocytic skin cancer, being 46 with Bowen’s disease (BOD), 134 with squamous cell carcinoma (SCC) and 127 with basal cell carcinoma (BCC), were investigated immunohistochemically using monoclonal antibody to cyclin D1 by the LSAB method, to assess the expression of cyclin D1 in skin cancer including its precursors. The positive rates of cyclin D1 immunostaining in BOD, SCC and BCC were 63.0%, 69.4% and 54.3%, respectively. The positive rates in dysplasia adjoining BOD, SCC and BCC were 43.6%, 67.9% and 59.8%, respectively. In morphologically normal skin, however, only 2 cases, 1 of SCC and 1 of BCC, exhibited positive staining. These findings suggested that overexpression of cyclin D1 is an early event in dysplastic lesions of skin. Overexpression of cyclin D1 was related to sun exposure, especially in dysplasia of SCC. The score for cyclin D1 expression in dysplasia of BCC was correlated with age. Expression of cyclin D1 markedly increased from normal skin through dysplasia to BOD, but was not significantly related to the degree of SCC differentiation. These findings demonstrate that the effect of cyclin D1 overexpression is restricted to proliferation of cells, so that they gain a growth advantage, but their differentiation is not increased. Comparison with the results for p53 protein expression in these tumors, a significant correlation with cyclin D1 expression was found in dysplasia in BOD and SCC, and in patients with BCC who were less than 74 years old. These findings suggested the hypothesis that prior aberrant p53 expression may affect or regulate the overexpression of cyclin D1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050461
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  • 9
    Electronic Resource
    Electronic Resource
    Search for accumulation of p53 protein and detection of human papillomavirus genomes in sebaceous gland carcinoma of the eyelid (1994)
    Springer
    Virchows Archiv 424 (1994), S. 503-509 
    Details
    ISSN: 1432-2307
    Keywords: Human papillomavirus ; p53 protein Sebaceous gland carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-one Japanese patients with sebaceous carcinoma of the eyelid were investigated for tumour incorporation of human papillomavirus (HPV) types-6, 11, 16, 18, 31, and/or 33 DNA by in situ hybridization with fluorescein isothiocyanate-labelled DNA probes, and for p53 protein accumulation by immunohistochemical analysis with an antibody to p53 protein. Thirteen tumours (61.9%), including 9 cases of multiple infections, were positive for HPV DNA. Positive signal in the nucleus was observed not only in the cancer cells, but also in the cells of surrounding normal sebaceous glands and epidermis. Positive nuclear staining of cancer cells with the antibody to p53 protein was detected in 12 cases (57.1%). p53 protein accumulation was more frequently observed in the clinically advanced cases, occasionally in association with recurrence and/or metastasis. Among the 12 p53-positive cases, 7 were also positive for the presence of HPV DNA. HPV infections exist in a high percentage of sebaceous carcinomas of the eyelid in Japan; the overexpression of p53 protein may be important in both carcinogenesis and progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191436
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  • 10
    Electronic Resource
    Electronic Resource
    Immunohistochemical study on the distribution of α and β subunits of S-100 protein in brain tumors (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 657-663 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor ; S-100 protein ; Subunit ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunohistochemical distribution of α and β subunits of S-100 protein (S-100α, S-100β, respectively) in 138 cases of human brain tumors was investigated by the avidin-biotin immunoperoxidase method. Brain tumors can be divided into four groups: group 1 [S-100α (+) and/or S-100β (+)]; astrocytoma, glioblastoma, ependymoma, subependymoma, oligodendroglioma, choroid plexus papilloma, gangliocytoma, meningioma, chordoma, malignant melanoma. Group 2 [S-100α (+) and S-100β (-)]; pineoblastoma, pituitary adenoma, craniopharyngioma, rhabdomyosarcoma. Group 3 [S-100α (-) and S-100β (+)]; acoustic Schwannoma. Group 4 [S-100α (-) and S-100β (-)]; medulloblastoma, malignant lymphoma, germinoma. The S-100β immunoreactivity pattern in brain tumors was similar to those obtained using conventional anti-S-100 protein sera. In the first group of brain tumors both the number of positively stained tumor cells and the staining intensity were generally greater for S-100β than for S-100α with a few exceptions including one gemistocytic astrocytoma, one subependymoma, one malignant melanoma, and some cases of glioblastomas. As to the relationship between malignancy and S-100 protein in glioma, S-100β immunoreactivity decreased according to degree of malignancy, while that of S-100α varied, suggesting a heterogeneity of tumor cells in glioblastomas. Immunostaining for S-100α and S-100β might become a useful diagnostic procedure in brain tumors and may give us more detailed and precise data of S-100 protein in brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296376
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