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  • 1
    Electronic Resource
    Electronic Resource
    Internal light-coupled optical device array (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 58 (1991), S. 1698-1700 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A novel internal light-coupled optical device (ILCOD) array is proposed, where the element consists of a pnpn digital optoelectronic switch and an npn phototransistor. The ILCOD with seven point-symmetric elements was fabricated. Quenching the light emission of the center element due to light coupling between the peripheral elements is observed. This quenching is achieved with an input optical power of 2.5 μW.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105112
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Properties of palytoxin-induced whole cell current in single rat ventricular myocytes (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 344 (1991), S. 247-251 
    Details
    ISSN: 1432-1912
    Keywords: Palytoxin ; Whole cell clamp ; Cardiac glycoside ; Rat ventricular cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the properties of the current induced by palytoxin in single ventricular cells of rats. The current was measured by a whole cell voltage clamp method. When the cell was held at −75 mV, palytoxin induced a sustained inward current in a concentration-dependent manner (2–100 pmol/1). The time-course of the inward current paralleled that of the depolarization. At a holding potential of + 50 mV, it caused an outward current. Palytoxin-induced current reversed at 0mV and its current-voltage relation was almost linear at either negative or positive voltage. Substitution of external NaCl with choline-Cl suppressed the palytoxin-induced inward current but not the outward current, by shifting the reversal potential to levels more negative than − 50 mV A cardiac glycoside, cymarin (10 and 100 μmol/l) partially inhibited the palytoxin-induced current without changing the reversal potential, only when applied before palytoxin. Palytoxin decreased the nicardipine-sensitive Ca 2+ current. These data suggest that palytoxin-induced inward current is carried by extracellular Na+ and the outward current is carried mainly by intracellular K+, and that the inward current is responsible for the toxin's depolarizing action. The antagonism by cysmarin indicates that the site of action of palytoxin is in the vicinity of the binding site of cardiac glycosides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167226
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A giant urinoma in a neonate without obstructive uropathy (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 831-832 
    Details
    ISSN: 1432-198X
    Keywords: Key words Urinoma ; Dysplastic kidney ; Obstructive uropathy ; Delivery ; Neonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a neonate with a giant urinoma and renal failure. A 7-day-old boy had a giant abdominal mass of 6.5 cm × 8 cm in the right quadrant, gastroesophageal reflux, and renal failure caused by the compression from the mass. Radiological observations revealed a multiseptated cyst and neither kidney could be detected. To relieve these symptoms percutaneous drainage was performed. The contents of the fluid were similar to the patient’s urine. The symptoms were improved by the drainage, and we found the left kidney to be absent and the right kidney small. Four prenatal ultrasound scans detected no cystic lesions in his abdomen. Neonatal urinomas are commonly complicated by obstructive uropathy, such as posterior urethral valves or ureteropelvic junction obstruction. These obstructive uropathies were ruled out by retrograde pyelography and voiding cystourethrography. A severely dilated upper pole of a double collecting system was also ruled out by intravenous pyelography and direct observation of the kidney during an open biopsy. The cause of the urinoma is still uncertain, but trauma during delivery and the dysplastic right kidney may be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004679900263
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  • 4
    Electronic Resource
    Electronic Resource
    Ca2+ spike initiation from sensitized inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in megakaryocytes (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 355-364 
    Details
    ISSN: 1432-2013
    Keywords: Internal calcium ; Inositol 1,4,5-trisphosphate ; Calcium spikes ; Sensitization ; Megakaryocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ca2+-mediated Ca2+ spikes were analysed in fura-2-loaded megakaryocytes. Direct Ca2+ loading using whole-cell dialysis induced an all-or-none Ca2+ spike on top of a tonic increase in cellular Ca2+ concentration ([Ca2+]i) with a latency of 3–7 s. The latency decreased with increasingly higher concentrations of Ca2+ in the dialysing solution. Spike size and its initiation did not correlate with the tonic level of [Ca2+]i. Thapsigargin completely abolished the Ca2+-induced spike initiation, suggesting that Ca2+ spikes originate from thapsigargin-sensitive Ca2+ pools. An inhibitor of phosphatidylinositide-specific phospholipase C (PLC), 2-nitro-4-carboxyphenyl-N,N-diphenyl-carbamate prolonged the latency without changes of spike size in most cases (6/9 cells), but abolished the spike initiation in the other cells (3/9). The results suggest that an increase in [Ca2+]i charges up the inositol-1,4,5-trisphosphate(InsP 3)- and thapsigargin-sensitive Ca2+ pools which progressively sensitize to low or slightly elevated levels of InsP3 by the action of Ca2+-dependent PLC until a critical Ca2+ content is reached, and then the Ca2+ spike is triggered. Thus, the limiting step of Ca2+ spike triggering is the initial filling process and the level of InsP3 in megakaryocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374545
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Morphological changes of small pancreatic cysts in response to secretin stimulation observation by endoscopic ultrasonography (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 648-652 
    Details
    ISSN: 1573-2568
    Keywords: pancreatic cyst ; secretin stimulation ; endoscopic ultrasonography ; differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is difficult to discriminate clinically the etiology of small pancreatic cysts using conventional methods. Endoscopic ultrasonography can delineate small lesions. In order to help differentiate the etiology of cystic lesions of the pancreas by endoscopic ultrasonography, we investigated morphological changes following stimulation of the pancreatic secretion with secretin. After an intravenous injection of secretin (50 CU), the size, shape, and echogenicity of a cyst smaller than 2 cm were recorded for 15 min. Of 17 cases examined, 10 patients showed an alteration of these factors. These cases were thought to be nonneoplastic cysts, which included all six cases where communication to the main pancreatic duct was demonstrated by ERCP. Five cases of neoplastic cyst did not show the change in shape and size. These results indicate that secretin stimulation provides useful information in the diagnosis of the etiology of pancreatic cyst by endoscopic ultrasonography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316795
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    Paper (German National Licenses)
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