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  • 1
    Electronic Resource
    Electronic Resource
    Brain iron pathways and their relevance to Parkinson's disease (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 79 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings and the observation of the ability of iron to induce aggregation and toxicity of α-synuclein have reinforced the critical role of iron in the pathogenesis of nigrostriatal injury. Presently the mechanisms involved in the disturbances of iron metabolism in PD remain obscure. In this review we summarize evidence from recent studies suggesting disturbances of iron metabolism in PD at possibly different levels including iron uptake, storage, intracellular metabolism, release and post-transcriptional control. Moreover we outline that the interaction of iron with other molecules, especially α-synuclein, may contribute to the process of neurodegeneration. Because many neurodegenerative diseases show increased accumulation of iron at the site of neurodegeneration, it is believed that maintenance of cellular iron homeostasis is crucial for the viability of neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00608.x
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  • 2
    Electronic Resource
    Electronic Resource
    Brain iron pathways and their relevance to Parkinson's disease (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neurochemistry 80 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0022-3042.2001.00742.x
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  • 3
    Electronic Resource
    Electronic Resource
    Multiple unilateral schwannomas: segmental neurofibromatosis type 2 or schwannomatosis? (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Schwannomas are benign solitary tumours of the peripheral nerve sheaths. The occurrence of multiple schwannomas usually implies hereditary disease. The most frequent syndrome associated with multiple schwannomas is neurofibromatosis type 2 (NF2), which is defined by bilateral vestibular schwannomas. Schwannomatosis is a distinct disease characterized by multiple pathologically proven schwannomas in the absence of vestibular schwannomas. It is not currently known if the presence of multiple schwannomas confined to a limb may represent a mosaic form of NF2 or a distinct disease, because mutation analysis of these tumours is not routinely performed. We report a 31-year-old patient who presented with multiple slowly growing subcutaneous tumours on his left arm. His family history was negative for cutaneous tumours or central nervous system disease, and he did not have additional features of NF2. Magnetic resonance tomography and ophthalmological examination excluded vestibular schwannoma and eye stigmata of NF2. After resection of three tumours, histological analysis confirmed the diagnosis of benign schwannomas. Molecular genetic analysis by temperature gradient gel electrophoresis and microsatellite marker analysis demonstrated two distinct mutations of the NF2 gene (NF2) in two different schwannomas, with concomitant loss of heterozygosity in both tumours. In contrast, neither normal skin nor peripheral blood lymphocytes revealed mutations of NF2. The clinical and molecular genetic findings suggest that the diagnosis in our patient is schwannomatosis rather than segmental NF2 because the mutations found in different tumours were not identical. The possibility of a localized predisposition for the acquisition of NF2 mutations is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05249.x
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  • 4
    Electronic Resource
    Electronic Resource
    Die Bestimmung der aktiven Blutmenge mittels Evans blue, radioaktivem P32 und Cr51 (1958)
    Springer
    Journal of molecular medicine 36 (1958), S. 800-808 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. In 131 Untersuchungen bei einem unausgewählten Material von 17 Gesunden und 114 Patienten mit den verschiedensten Erkrankungen ergab sich die Übereinstimmung der mittels Evans blue und Hämatokrit errechneten Blutmenge mit den aus der Bestimmung der Plasmamenge und der Markierung der Erythrocyten mittels radioaktivem P32 gewonnenen Werten mit einem Korrelationsfaktor von 0,82 (Limes 0,258). 2. Die gleichzeitige Bestimmung der Blutmenge mit Evans blue und Hämatokrit sowie mittels Cr51 ergab ebenfalls eine Übereinstimmung der Mittelwerte der mit beiden Methoden gefundenen Blutmengen. 3. Auf Grund dieser Versuche ergibt sich für das Verhältnis Körper-Hämatokrit: venösem Hämatokrit ein Faktor von annähernd 1,0, d. h. eine Korrektur der venösen und der capillären Hämatokritwerte ist unnötig. Hierdurch werden frühere direkte Bestimmungen des Hämatokrit aus capillärem, venösem und arteriellem Blut bestätigt. 4. Die an einem großen statistisch verwertbaren Material durchgeführten Kontrolluntersuchungen mittels P32 und Cr51 haben erneut die Genauigkeit der Evans blue-Methode in der von uns geübten Modifikation erwiesen. Bei klinischen Untersuchungen kann die Anwendung der Isotopenmethode auf ganz spezielle Fragestellungen beschränkt werden. 5. Entsprechend der Definition der aktiven Blutmenge als demjenigen Blutanteil, in dem sich eingeführte Testsubstanzen kurzfristig mischen, wurden alle Untersuchungen mit kurzen Analysenzeiten (4 bis 10 min nach der Injektion) durchgeführt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01481947
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  • 5
    Electronic Resource
    Electronic Resource
    Early Postoperative Transcranial Sonography (TCS), CT, and MRI after Resection of High Grade Glioma: Evaluation of Residual Tumour and its Influence on Prognosis (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 1089-1097 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Brain neoplasms; magnetic resonance imaging; tomography, X-ray computed; ultrasonics.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Purpose. In this prospective study the results of multimodal postoperative neuro-imaging were related to the survival of patients with high grade gliomas.  Methods. All 73 patients included underwent microsurgical tumour resection and had postoperative CT and transcranial sonography (TCS) examinations. In addition, 35 of the 73 patients received an early postoperative MRI. Patients were followed up for at least one year.  Findings. At the end of the 7 year study period 56 patients had died. The median survival time was 371 days. Survival rate was significantly higher in patients with anaplastic astrocytomas and inpatients displaying complete tumour resection on MRI (log-rank-test, p〈0.05) or a small postoperative residual tumour bulk on TCS (log-rank-test, p〈0.05). Cox proportional hazards model identified histological tumour grade, postoperative Karnofsky index, complete resection based on MRI and small postoperative residual tumour mass on TCS as independent predictors of survival.  Interpretation. This study demonstrates that early postoperative neuro-imaging has prognostic implications for the survival of patients with high grade gliomas. According to our results postoperative imaging with MRI and TCS is a valuable prognostic with regard to patient survival and should therefore be implemented in postoperative follow-up. It also helps to evaluate the efficacy of adjuvant therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070035
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  • 6
    Electronic Resource
    Electronic Resource
    The basal ganglia in haemochromatosis (2000)
    Springer
    Neuroradiology 42 (2000), S. 9-13 
    Details
    ISSN: 1432-1920
    Keywords: Key words Haemochromatosis ; Magnetic resonance imaging ; Computed tomography ; Transcranial ultrasound ; Nucleus, lentiformis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haemochromatosis is characterised by deposition of iron-containing pigment in various organs, but little is known about possible deposition in the brain and its clinical impact. We therefore investigated 14 patients with hereditary haemochromatosis with MRI, CT and transcranial ultrasound (TCS) and examined them neurologically. In six of the patients dense lesions were found within the lentiform nucleus on CT, all of whom displayed hyperechogenic lesions in the same area on TCS, as did one other patient. In these patients the relative signal intensities of the lentiform nucleus measured by MRI relaxometry were higher. No patient had clinical signs of basal ganglia disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050002
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  • 7
    Electronic Resource
    Electronic Resource
    Prognose der Schnittholz-Qualität auf der Grundlage der Rundholz-Sortierung (2000)
    Springer
    Holz als Roh- und Werkstoff 58 (2000), S. 168-176 
    Details
    ISSN: 1436-736X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: prEN 1927 for roundwood and DIN 4074 for sawntimber did not result in any stronger correlation. Though the application of common European grading rules is recommended, some adaptations to prEN 1927 should be made to improve the prediction of sawn timber quality.
    Notes: prEN 1927 in den drei Partnerländern führte bei anschließender einheitlicher Sortierung des Schnittholzes nach DIN 4074 zu keinem deutlich verbesserten Zusammenhang. Um die Vorteile einer einheitlichen europäischen Normierung zu nutzen, sollten die bestehenden Möglichkeiten zur Nachbesserung der prEN 1927 aufgegriffen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001070050408
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  • 8
    Electronic Resource
    Electronic Resource
    über das elastische Verhalten von PolytetrafluorÄthylen (1959)
    Springer
    Colloid & polymer science 167 (1959), S. 44-55 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung Für die Ermittlung der elastischen Eigenschaften des partiell-kristallinen PolytetrafluorÄthylens (PTFÄ) wurden zwei Me\verfahren benutzt. Im Zeitbereich von etwa 0,5 bis 104 s wurde der Relaxationsmodul mit einem Dehnspannungsrelaxometer gemessen; im Frequenzbereich von etwa 10 bis 2000 Hz wurden der dynamische ElastizitÄtsmodul und der zugehörige Verlustfaktor mit der Biegeresonanzmethode bestimmt. Die Me\temperatur wurde im Bereich −90 bis 225
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01810122
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  • 9
    Electronic Resource
    Electronic Resource
    Über das dynamisch-elastische Verhalten von Polyamiden und Polyurethanen in Abhängigkeit von Frequenz, Temperatur und Wassergehalt (1957)
    Springer
    Colloid & polymer science 152 (1957), S. 1-8 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung Die Abhängigkeit des dynamisch-elastischen Verhaltens verschiedener Polyamide und Polyurethane von der Frequenz, der Temperatur und insbesondere vom Wassergehalt wurde untersucht. Gemessen wurden zu diesem Zweck der dynamische Elastizitätsmodul und der zugehörige Verlustfaktor im Bereich 10 ... 1000 Hz und −30...+90 °C. Es wurde auf molekularen Relaxationsprozessen beruhende mechanische Dispersion mit der zugehörigen maximalen Absorption in Abhängigkeit von allen drei Veränderlichen beobachtet. Das Wasser erhöht die Beweglichkeit der relaxierenden Molekülkettensegmente. Wenn man die Stoffe bei gleichen relativen Wassergehalten (bezogen auf die Sättigungswerte) vergleicht, sind die Unterschiede ihres Verhaltens gering; dies gilt sowohl für die Lage der Dispersionsgebiete als auch für die Höhe der Dispersionsstufen und die Beträge der Verlustfaktormaxima. Das molekulare Verhalten, insbesondere dessen Abhängigkeit vom aufgenommenen Wasser, das zu Anomalien im Verlauf des Elastizitätsmoduls führt, wird an Hand der vorliegenden Meßresultate und der Ergebnisse anderer Autoren diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01533992
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanische Relaxationserscheinungen in nicht weichgemachten hochpolymeren Kunststoffen (1955)
    Springer
    Colloid & polymer science 140 (1955), S. 1-32 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01513351
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