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  • 1995-1999  (17)
  • 1990-1994  (29)
  • 1920-1924  (1)
  • 1905-1909  (2)
  • 11
    Electronic Resource
    Electronic Resource
    The secretion of amylase, phospholipase and protease from Aeromonas salmonicida, and the correlation with membrane-associated ribosomes (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 13 (1990), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The following extracellular enzymes have been readily detected in the culture filtrates from Aeromonas salmonicida: amylase, phospholipase, lysophospholipase and ribonuclease. Amylase and phospholipase have been partially characterized. Evidence suggests that glycogen may be the natural substrate for amylase, and that the role of the enzyme in natural infection is to digest glycogen present in fish muscle. The secretion of amylase activity is suppressed by the addition of glucose to the growth medium. The amounts of amylase, phospholipase and protease that can be detected in culture filtrates decreases with increase in the growth temperature from 25 to 32°C. This marked decrease in secretion of hydrolytic enzymes occurs although the initial growth rates at 25 and 32°C are similar. Free and membrane associated ribosomes have been isolated from cultures grown at 25 and 32°C. At 32°C there is a smaller proportion of membrane-associated ribosomes and this is consistent with the hypothesis that extracellular enzymes from Aeromonas salmonicida are secreted on membrane-bound polysomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1990.tb00805.x
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  • 12
    Electronic Resource
    Electronic Resource
    Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ranitidine bismuth citrate is a novel compound formed from ranitidine and a bismuth citrate complex. In conscious dogs, ranitidine bismuth citrate had similar activity to ranitidine hydrochloride as an inhibitor of histamine-induced gastric acid secretion when oral doses containing equivalent amounts of ranitidine base (0.1 or 0.3 mg/kg) were compared. In the rat, ranitidine bismuth citrate (3–30 mg/kg p.o.) prevented gastric mucosal damage induced by ethanol (fundic damage) and indomethacin (antral damage).Ranitidine hydrochloride and tripotassium dicitrato bismuthate were also effective against indomethacin induced damage, but were both significantly less potent than ranitidine bismuth citrate in this model.Ranitidine hydrochloride was inactive against ethanol-induced damage. In vitro, ranitidine bismuth citrate (1 mmol/L) inhibited human pepsin isoenzymes 1, 2, 3 and 5. Pepsin 1 was inhibited to a similar extent by ranitidine bismuth citrate, bismuth citrate and tripotassium dicitrato bismuthate at concentrations equivalent to 1 mmol/L bismuth, but ranitidine (1 mmol/L) was inactive. Ranitidine bismuth citrate was more potent than tripotassium dicitrato bismuthate as an inhibitor of pepsins 2, 3 and 5. Ranitidine bismuth citrate inhibited both Helicobacter pylori (effective concentration 4–32, μg bismuth/ml) and H. mustelae (1–4,μg bismuth/ml); similar results were obtained with tripotassium dicitrato bismuthate. Bismuth citrate was slightly less effective, and ranitidine hydrochloride was inactive (〉 125, μg/ml). In ferrets naturally colonized with H. mustelae, oral treatment with ranitidine bismuth citrate, 12 or 24 mg/kg twice daily for 4 weeks, caused a dose related clearance of H. mustelae. Qualitatively similar results were obtained in a small study with tripotassium dicitrato bismuthate and bismuth citrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00094.x
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  • 13
    Electronic Resource
    Electronic Resource
    The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Extensive study of the p53 gene has established its role as a tumour-suppressor gene, and the involvement of mutant p53 in a wide spectrum of human malignancy. Many mutations of p53 result in a protein product that is abnormally stable, so that it becomes readily detectable by immunocytochemistry. In contrast, under normal conditions, it has been considered that levels of wild-type p53 were too low to be detectable. Although positive immunocytochemistry has been used as a marker of mutation, recent evidence suggests that this assumption may not always be valid. We have carried out both PCR-sequencing of exons 5-8 of the p53 gene in 20 basal cell carcinomas (BCC), and immunocytochemistry of these tumours with the anti-p53 antibody Do7. Twenty cases of Bowen's disease, in which we had previously documented mutations, were also immunostained. We report a low rate of p53 mutation in the BCCs we examined (2/20), and a discrepancy between tumours with positive immunostaining and those with mutation in both Bowen's disease and BCC. Of eight tumours in which we detected mutation, only four were immunopositive; of 19 immunopositive samples, only four showed detectable mutation. We discuss the implications of our results for the use of positive immunostaining in clinical diagnosis, and the involvement of p53 in skin carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb11840.x
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  • 14
    Electronic Resource
    Electronic Resource
    Codon 12 Harvey-ras mutations are rare events in non-melanoma human skin cancer (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 128 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: ras mutations have been reported as an early event in some human malignancies and in the mouse skin model of multistep carcinogenesis; early studies in human non-melanoma skin cancers have reported variable rates of ras mutations. A recent study, however, has reported a high frequency of activating mutations of the Harvey-ras proto-oncogene in non-melanoma skin cancers, and the site specificity of the mutation at the second position of codon 12 prompted us to re-examine the importance of Ha-ras codon 12 mutations as an early event in the development of these tumours, using a combination of PCR and restriction fragment polymorphism of codon 12 of the Ha-ras gene. Dilution experiments confirmed that the method was sensitive and capable of detecting mutations at this codon when only 4% of the total alleles are mutated. We were surprised to find no mutations in the 40 basal cell carcinomas. 12 squamous cell carcinomas and 12 cases of Bowen's disease studied. We conclude that Ha-ras codon 12 mutations are rare events in human non-melanoma skin cancer in the U.K. The marked differences in the frequency of codon 12 Ha-ras mutations in published studies may relate to either technical artefacts, or differences in the molecular epidemiology between areas of low and high sun exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb15137.x
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  • 15
    Electronic Resource
    Electronic Resource
    Structures of three 1-[(diphenylphosphinoyl)methyl]cyclohexanols (1992)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 690-693 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270191010430
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  • 16
    Electronic Resource
    Electronic Resource
    The thermal polymerisation of a diacetylenic liquid crystal (1992)
    Springer
    Polymer bulletin 29 (1992), S. 661-668 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary In this paper, the polymerisation of a conjugated liquid crystalline diacetylene is reported. The structure of the polymer is discussed in relation to results from spectroscopic studies and molecular weight determinations. The polymer has a backbone structure analogous to that of other polydiacetylenes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01041152
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  • 17
    Electronic Resource
    Electronic Resource
    A phase I–II study of bi-weekly paclitaxel as first-line treatment in metastatic breast cancer (1998)
    Springer
    Annals of oncology 9 (1998), S. 1247-1249 
    Details
    ISSN: 1569-8041
    Keywords: metastatic breast cancer ; paclitaxel ; scheduling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Single-agent bi-weekly paclitaxel was studied as first-line metastatic treatment for breast cancer in a phase I–II trial. Patients and methods: Thirty-eight women with metastatic breast cancer were enrolled. Thirty-seven are evaluable for toxicity, 35 for response. Results: The MTD was defined at 160 mg/m2 q two weeks with dose limiting toxicity in two patients consisting of hematological toxicity (1) and neurotoxicity (2). Twenty patients were treated at 150 mg/m2, the recommended dose. Response rates were two CRs and nine PRs (overall 61%) at the RD of 150 mg/m2 and three CRs and 11 PRs for an overall RR of 67% for the two top doses. Conclusions: The good drug tolerance, response rates, and convenience over weekly treatment suggest this may be a worthwhile regimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008445123416
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  • 18
    Electronic Resource
    Electronic Resource
    Response of Phorodon humuli to yellow and to green hop foliar colours (1991)
    Springer
    Entomologia experimentalis et applicata 60 (1991), S. 95-99 
    Details
    ISSN: 1570-7458
    Keywords: Aphididae ; Phorodon humuli ; host selection ; foliar colour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164963
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  • 19
    Electronic Resource
    Electronic Resource
    Effect of nitrogen fertiliser on temporal and spatial variation of mineral nitrogen and microbial biomass in a silvopastoral system (1995)
    Springer
    Biology and fertility of soils 19 (1995), S. 177-185 
    Details
    ISSN: 1432-0789
    Keywords: Excreta ; Fertiliser ; Microbial biomass ; Nitrogen ; Silvopastoral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract This paper describes a field study to assess the effect of increasing the frequency of split applications of N fertiliser on the pattern of plant uptake, soil N availability, and microbial biomass C and N. Measurements were taken during the growing season in different positions relative to young trees (Prunus avium L.) in an upland silvopastoral system in its first year after establishment. At fertiliser rates of 72 and 144 kg ha-1 N applied as NH4NO3, increasing the number of split applications increased N uptake by the pasture. Mineral forms of soil N measured 2 weeks after application indicated that residual NH inf4 sup+ -N and total mineral N were also greater in this treatment on certain dates. Soil NO inf3 sup- -N was positively correlated with the soil moisture content, and nitrification reached a maximum in early May and declined rapidly thereafter except within the herbicide-treated areas around the trees where soil moisture had been conserved. Results of the study suggest that high NO inf3 sup- -N in herbicide-treated areas was probably caused by mineralisation of grass residues and low uptake by the tree rather than by preferential urine excretion by sheep sheltering beside the trees. Mean microbial biomass C and N values of 894 and 213 kg ha-1, respectively, were obtained. Microbial C was slightly increased by the higher frequency of split applications at 144 kg ha-1 N and was probably related to the greater herbage production with this treatment. Microbial N was not significantly affected by the N treatments. Both microbial biomass C and N increased during the growing season, resulting in the net immobilisation of at least 45 kg ha-1 N which was later released during the autumn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336156
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  • 20
    Electronic Resource
    Electronic Resource
    Pseudomicrodochium fusarioides sp. nov., isolated from human bronchial fluid (1991)
    Springer
    Mycopathologia 114 (1991), S. 159-161 
    Details
    ISSN: 1573-0832
    Keywords: Pseudomicrodochium ; phaeohyphomycosis ; lung isolate ; new species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A fungus from bronchial lavage fluid from a patient with pulmonary infiltration was isolated in pure culture and identified as a species of Pseudomicrodochium. It is compared and contrasted with other species of the genus, in particular P. suttonii, and formally described as P. fusarioides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437207
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