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  • 1
    Electronic Resource
    Electronic Resource
    CD86 (B7–2) antigen on B cells from atopic patients shows selective, antigen-specific upregulation (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To determine whether B7 signals are associated with atopic responses in man, we assayed CD80 and CD86 expression on B cells and monocytes from atopic patients and controls. Peripheral blood mononuclear cells from 10 patients with perennial allergic rhinitis and from 10 normal subjects were cultured in the presence or absence of house-dust-mite antigen, and B cells and monocytes were assayed for expression of CD80 and CD86 by flow cytometry. CD86 on B cells was significantly and selectively upregulated in all atopic subjects, but not in normal subjects, whereas CD80 expression was not altered in B cells from the atopic subjects or controls. In contrast, both CD80 and CD86 were upregulated in monocytes from the atopic subjects as well as the controls. However, CD86 upregulation was significantly higher in the atopic subjects than in controls. Our results seem to suggest that selective upregulation of CD86 on B cells by a challenging antigen may play a critical role in the development of Th2 cells in patients with atopic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1998.tb04091.x
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  • 2
    Electronic Resource
    Electronic Resource
    The squeezing potential of rock around tunnels: Theory and prediction with examples taken from Japan (1996)
    Springer
    Rock mechanics and rock engineering 29 (1996), S. 125-143 
    Details
    ISSN: 1434-453X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Summary Large deformations of surrounding media around tunnels are often encountered during excavations in rocks with squeezing characteristics. These deformations may sometimes continue for a long period of time. Predictions of deformations of tunnels in such grounds are urgently needed, not because of stability concerns, but also of their sevicability. In the present study, the squeezing phenomenon of rock around tunnels and its mechanism and associated factors are first clarified by carefully studying failures of tunnels, and a survey of tunnels in squeezing rocks in Japan is presented and its results are summarised. Then, a practical method is proposed to predic the squeezing potential and deformation of tunnels in squeezing rock and this method has beeen applied to actual tunnelling projects, where squeezing problems were encountered, to check its applicability and validity. Finally, an extension of this method to the time-dependent behaviour of squeezing rocks is given and an application of this method to an actual tunnel is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01032650
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  • 3
    Electronic Resource
    Electronic Resource
    Primary rhabdomyosarcoma combined with chronic paragonimiasis in the cerebrum: a necropsy case and review of the literature (1986)
    Springer
    Acta neuropathologica 72 (1986), S. 170-177 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor ; Rhabdomyosarcoma ; Immunohistochemistry ; Ultrastructure ; Cerebral paragonimiasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A necropsy case of a primary rhabdomyosarcoma with chronic paragonimiasis in the cerebrum of a 68-year-old man is reported. The clinical data showed a right hemiplegia and dysarthria which became lethal in 6 months even though operation and radiation therapy were performed. Computed tomography revealed a large low-density area associated with the peripheral enhancement in the left basal ganglia, and multiple conglomerated calcified masses in the left temporal and occipital lobes. Biopsied and necropsied materials of the tumor in the basal ganglia was reddish brown in color and histologically was composed of purely mesenchymal derivatives with both embryonal and mature striated muscle cells but neither neuronal nor glial elements. Some of the tumor cells with extending slender cytoplasms showed obvious cross striations at the light and electron microscope levels and immunohistochemical reactivity for myoglobin. All tumor cells were also positive for vimentin, but not for glial fibrillary acidic protein. The clinical and necropsy findings revealed no primary lesion anywhere but in the brain. In addition, numerous dead oval eggs ofParagonimus westermani were found in many cystoid lesions encapsulated by thick connective tissues with calcification and/or ossification. Clinicopathological features of 24 cases of primary rhabdomyosarcoma of the central nervous system reported in the literature are reviewed briefly. The histogenesis of this tumor are discussed together with comments on cerebral paragonimiasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685980
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  • 4
    Electronic Resource
    Electronic Resource
    Isotopic and elemental evidence for a relationship between kimberlite and Zaire cubic diamonds (1988)
    [s.l.] : Nature Publishing Group
    Nature 336 (1988), S. 665-667 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Chondrite-normalized REE + (Rb, Sr, Ba) patterns of Zaire cubic diamonds. Normalized values are from refs 12 (REE4- Ba), 13 (Sr) and 14 (Rb). The diamonds studied here contain characteristic micro-inclusions. Previous studies on inclusions in these diamonds2'3 have revealed enrichment ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/336665a0
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  • 5
    Electronic Resource
    Electronic Resource
    Successful Embolization of Coronary Arteriovenous Fistula Using an Interlocking Detachable Coil (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 152 -155 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Coronary arteriovenous fistula — Embolization — Interventional catheterization — Interlocking detachable coil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Although the efficacy and feasibility of coil embolization of coronary arteriovenous fistulas have been reported, the procedure may be complicated by migration of the coil into peripheral vessels or pulmonary arteries. We report two cases of successful coil embolization of such lesions using an interlocking detachable coil. This system can provide safer and more effective coil embolization in patients with coronary arteriovenous fistula.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900139
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  • 6
    Electronic Resource
    Electronic Resource
    Noninvasive Evaluation of Systolic Pressures of Pulmonary Artery and Right Ventricle Using Contrast-Enhanced Doppler Echocardiography: Comparative Study Using Sonicated Albumin or Glucose Solution (1996)
    Springer
    Pediatric cardiology 17 (1996), S. 175-180 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Albumin — Contrast Doppler echocardiography — Pulmonary artery pressure — Right ventricle pressure — Tricuspid regurgitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Evaluation of pulmonary arterial pressure is essential for the diagnosis and management of patients with congenital heart disease; it is usually done by cardiac catheterization. An alternative, noninvasive method may be clinically more useful. The purpose of this study was to assess the usefulness of the noninvasive determination of systolic pressure of the pulmonary artery and right ventricle by contrast-enhanced Doppler echocardiography. We selected 30 pediatric patients (28 with trivial or nonsignificant tricuspid regurgitant Doppler signals and 2 with significant tricuspid regurgitant Doppler signals) aged 2 months to 21 years. The flow velocity of tricuspid regurgitation was measured with continuous-wave Doppler of the right ventricular inflow view or left parasternal or apical four-chamber view before and after injection of two types of contrast medium (hand-agitated 5% glucose or sonicated albumin). The systolic pressure of the pulmonary artery was assessed as the estimated right ventricular systolic pressure (albumin method) minus the peak pressure gradient across the pulmonary valve (nonenhanced Doppler method). After injection of hand-agitated 5% glucose and sonicated albumin, trivial tricuspid regurgitation signals were enhanced in 25 of 28 patients (89%). In two patients, spectral envelopes were well defined enough to obtain the peak systolic velocity of the tricuspid regurgitation jet without contrast medium injection. Peak velocity was not altered by injection of contrast medium in these patients. There was significant correlation between the estimation by contrast-enhanced Doppler using hand-agitated 5% glucose and the cardiac catheterization measurement of the transtricuspid pressure gradient (r= 0.88). The transtricuspid pressure gradients obtained by continuous-wave Doppler during sonicated albumin enhancement corresponded closely to those measured by cardiac catheterization (r = 0.95). Pulmonary arterial and right ventricular systolic pressures measured by Doppler using sonicated albumin and those obtained by cardiac catheterization were highly correlated (right ventricle, r = 0.96; pulmonary artery, r = 0.95). In conclusion, this technique may be a valuable noninvasive method for determining accurate right ventricular and pulmonary arterial systolic pressures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900037
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  • 7
    Electronic Resource
    Electronic Resource
    Balloon Dilatation of the Pulmonary Valve in a Patient with Pulmonary Atresia and Intact Ventricular Septum Using a Commercially Available Radiofrequency Catheter (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 61-63 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Pulmonary atresia and intact ventricular septum — Radiofrequency catheter — Interventional catheterization — Balloon dilatation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Using a commercially available 5F deflectable radiofrequency catheter, we have succeeded in percutaneous valvotomy of an imperforate pulmonary valve and consecutive balloon dilatation in a baby with pulmonary atresia and intact ventricular septum. After the procedure, right ventricular systolic pressure fell from 125 mmHg to 65 mmHg, and right ventriculography demonstrated anterograde blood flow into the pulmonary arteries. There were no major complications. Doppler echocardiography at 1 year after the procedure demonstrated a pressure gradient across the pulmonary valve of 20 mmHg with mild pulmonary and tricuspid regurgitations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900112
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  • 8
    Electronic Resource
    Electronic Resource
    Carotid Artery Approach to Balloon Aortic Valvuloplasty in Infants with Critical Aortic Valve Stenosis (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 288 -291 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Critical aortic valve stenosis — Carotid artery approach — Interventional catheterization — Balloon valvuloplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We compare the clinical efficacy of two approaches for balloon aortic valvuloplasty (BAV) in infants with critical aortic valve stenosis. The approaches were through the carotid artery and the femoral artery. Eight catheterizations for BAV were performed in seven consecutive patients with critical aortic stenosis: four BAVs were approached through the femoral artery and four through the right common carotid artery. We inserted a 5F sheath into the right common carotid artery by a cutdown procedure; after BAV the sheath was removed and the carotid arteriotomy sutured with 7-0 monofilament. Two cases in which the femoral artery approach was used resulted in failure to perform BAV; two cases had complications. All four cases with the carotid artery approach were successful, with no complications; aortography performed 3 months after one balloon valvuloplasty revealed a smooth, unobstructed right carotid artery. Use of the carotid artery approach may reduce serious complications with BAV and offers quicker, easier maneuvering in infants and neonates with critical aortic valve stenosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900176
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  • 9
    Electronic Resource
    Electronic Resource
    Immortalization of human lymphocytes by co-cultivation with lethally irradiated autologous T-cell lines harbouring human T-cell leukaemia virus-I (1985)
    Springer
    Journal of cancer research and clinical oncology 110 (1985), S. 82-84 
    Details
    ISSN: 1432-1335
    Keywords: Human T-cell leukaemia virus ; Transformation ; Lymphocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human adult peripheral blood lymphocytes were successfully immortalized by co-cultivation with irradiated autologous and homologous T-cell lines harbouring human T-cell leukaemia virus-I (HTLV-I). The efficiency of transformation was the same in both cases. The participation of alloantigen stimulation in co-cultivation procedures is discussed, and it is stressed that factors other than alloantigen stimulation might be required for the efficient immortalization of human T-lymphocytes in vitro by HTLV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402508
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  • 10
    Electronic Resource
    Electronic Resource
    Electron microscopic and immunohistochemical observations of differentiation of human myeloid leukemia line, PL-21 (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 203-208 
    Details
    ISSN: 1432-1335
    Keywords: PL-21 cell line ; Leukemia cell differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new human myeloid leukemia cell line, PL-21, consisting of promyelocytes, was microscopically and immunohistochemically studied for their maturation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and retinoic acid (RA). More than 80% of PL-21 cells cultured for 4 days with 10 ng/ml of TPA became macrophage-like cells with functional and histochemical properties consistent with monocytes/macrophages. The cells adhered to the plastic flask, developed phagocytic activity and macrophagespecific intracytoplasmid α subunit of S-100 protein, and had reduced myeloid-specific cytochemical markers. In contrast, RA-treated PL-21 cells displayed mature neutrophil-like morphology after 7 days of exposure. Most of the cells had reduced nitro blue tetrazolium and acquired phagocytic activity with persistence of myeloid-specific cytochemical markers such as peroxidase, naphthol-AS-D chloroacetate esterase, and Sudan black B. These results indicate that the PL-21 cell line ca be induced to mature into two directions of macrophages and neutrophils by chemical inducers, and will provide a useful tool for studying the differentiation of leukemic cells and searching for other differentiation inducers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389235
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