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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 51 (1982), S. 197-220 
    ISSN: 1432-0738
    Keywords: Acute toxicity ; LD50 method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 170 acute toxicity determinations, carried out in rats, mice, and guinea pigs after oral and parenteral administration during the past 5 years, using 5 ♂/5 ♀ animals per dose, were evaluated with respect to the possibility of a reduction of animals necessary for obtaining LD50 values with limits of confidence. Calculations were performed on existing data; no additional animal experiments were initiated for the purpose of this paper. For the majority of substances 3 ♂/3 ♀ animals per dose would have sufficed for the determination of a LD50 value with limits of confidence. Even when using 2 ♂/2 ♀ animals per dose, in most cases sufficently acceptable LD50 values can be determined, if the period of observation — conventionally 4 weeks — would be doubled. Using this procedure, 75% of the animals could be saved. The reduced number of animals and the labor saved thereby would allow for a more individualized observation of single animals thus optimizing the evaluation of acute toxicity testing.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1434-601X
    Keywords: 25.70.Gh ; 25.70.Jj ; 25.70.Pq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In a multidetector experiment on 26 or 30 AMeV32S+58Ni, up to four coincident heavier or intermediate-mass fragments were observed. One of these occasionally has the characteristics of a projectile-like fragment, up to three may be attributed to the decay of the heavy reaction product. Taking the velocity of the fragments as a measure of the heavy-product excitation energy, one finds evaporation, fission and multifragmentation to follow one another with rising excitation. Model simulations of sequential decay with up to two binary fissions and, alternatively, of simultaneous statistical multifragmentation were performed for comparison with experimental distributions of mass, velocity and (for events with three slow intermediate-mass fragments) relative azimuthal angle. Though in the three-fragment events indications of simultaneous multifragmentation are present, the sequential binary decay predominates. Evaporated protons and α particles detected in coincidence have a mean multiplicity growing with excitation energy, while the temperature governing the spectra has a plateau with a value of about 5.5 MeV.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 309 (1982), S. 183-184 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Mass distributions of fission-like fragments from the system 271 MeV40Ar+165Ho have been measured as a function of the angle. An expected dependence of the mass distribution width on angle due to the claimed contribution of “fast fission” could not be observed.
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-0649
    Keywords: PACS: 07.60.Pb; 42.30; 77.80.Dj
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1432-0630
    Keywords: PACS: 07.79.C; 61.16.C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. An internal reflection mode is introduced for scanning near-field optical microscopy (SNOM) with the tetrahedral tip. A beam of light is coupled into the tip and the light specularly reflected out of the tip is detected as a photosignal for SNOM. An auxiliary STM mode is used to control the distance during the scanning process and to record the topography of the sample simultaneously with the SNOM image. Images were obtained of different metallic samples which show a contrast in the order of 10% of the total reflected photosignal. In images of metallic samples an inverted contrast is consistently obtained compared to images previously obtained of comparable samples in a transmission mode. The contrast shows a pronounced dependence on the polarization of the incident beam with respect to the orientation of the edges of the tip. In the case of gold surfaces, the photosignal as a function of distance between the tip and the surface shows a pronounced peak in the near-field range of 0–20 nm which is tentatively attributed to the excitation of surface plasmons on the gold surface. The pronounced near-field effects and the strong contrast in the near-field images and the resolution well below 50 nm are an indication of a highly efficient coupling of the incident beam to a local excitation of the tip apex which is essential for the function of the tip as a probe for SNOM.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 121 (1916), S. 945-946 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 121 (1916), S. 947-954 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 121 (1916), S. 955-961 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei drei Patienten fanden sich luetische Krankheitsherde, deren Aussehen so sehr dem Bilde der Tuberculosis cutis verrucosa glich, daß die richtige Diagnose auf Grund des klinischen Bildes nicht zu stellen war.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 123 (1916), S. 331-344 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Mit der Neisserschen Gk.-Vakzine (Gonokokkenbouillon) läßt sich durch die Intradermoreaktion bei der überwiegenden Mehrzahl gonorrhoisch Erkrankter eine Hautallergie feststellen, bei gesunden Individuen ist die Reaktion nur in vereinzelten Fällen positiv. 2. Diese Hautallergie überdauert den Krankheitsprozeß einige Zeit, erlischt aber meistens nach einigen Monaten. 3. Das Zustandekommen der Allergie ist nicht an eine besondere klinische Form der Gonorrhoe gebunden, sondern von dieser unabhängig. 4. Zur Ausbildung der Umstimmung braucht es in der Regel mindestens 6 Tage. Vorher sind positive Reaktionen nur höchst selten zu erhalten. Ist die Allergie einmal eingetreten, so übt die Krankheitsdauer keinen Einfluß mehr auf diese aus. 5. Eine Wiederholung der Erkrankung scheint das Auftreten der Allergie nicht zu begünstigen. 6. Durch Arthigonbehandlung (subkutan und intravenös) gelang es nicht, eine Veränderung der Intradermoreaktion in bezug auf Häufigkeit und Intensität zu erzeugen. 7. Einige Zeit nach der Heilung kann die Reaktion schwächer werden oder ganz verschwinden, nicht aber während der Krankheitsdauer selbst. Es ist daher möglich, durch den Nachweis einer Veränderung der Reaktion im Sinne des Negativwerdens Nachkrankheiten der Gonorrhoe von echten gonorrhoischen Prozessen zu unterscheiden.
    Type of Medium: Electronic Resource
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