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  • 1995-1999  (4)
  • Therapy  (2)
  • 13.18.4  (1)
  • Apis cerana  (1)
  • 1
    ISSN: 1432-1238
    Schlagwort(e): Acute pancreatitis ; Therapy ; Dextran ; Hypertonic ; Colloid ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective Ultrahigh-molecular dextran (500 000 DA) has been shown to prevent pancreatic necrosis when given 30 min after induction of pancreatitis. This study should clarify the following: (a) are dextrans still effective after prolongation of the therapy-free interval? (b) what is the impact of the molecular weight of the dextrans? and (c) is their effect influenced by the dextran concentration or by the addition of hypertonic saline? Animals and interventions Acute pancreatitis was induced in 70 male dextran-tolerant Wistar rats using intraductal bile-salt infusion and intravenous hyperstimulation. After 3 h, animals were assigned to one of seven groups (n=10 per group) receiving either Ringer solution or different dextrans (10%) including 70 000 Da (DEX-70), 160 000 Da (DEX-160), 300 000 Da (DEX-300) or 500 000 Da (DEX-500). Additional groups included DEX-70 (6%) and DEX-70 (10%) in combination with hypertonic NaCl (7.5%) (HHS-70). Ringer solution was given at 24 ml/kg and all dextrans at 8 ml/kg. Measurements and results Trypsinogen activation peptides (TAP) were quantified in ascites and acinar necrosis after death or sacrifice at 9 h. As an index of less pathological trypsinogen activation, the mean TAP levels in ascites were significatly lower in DEX-70 and DEX-160 compared to Ringer controls (p〈0.05,t-test). Furthermore, the amount of acinar necrosis was significantly lower in all dextran groups except the HHS-70 in comparison with Ringer controls (p〈0.01,t-test). Finally, mortality was significantly reduced from 60% in Ringer controls to 10 and 0%, respectively, in the groups treated with DEX-70 and DEX-160 (p〈0.03, Fisher's Exact test). There was a similar trend in all other groups except the HHS-70. Conclusions Despite a therapy-free interval of 3 h, dextrans reduce trypsinogen activation, prevent acinar necrosis, and improve survival in necrotizing rodent pancreatitis. The molecular weight and concentration of dextran are of secondary importance for these beneficial effects.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1238
    Schlagwort(e): Key words Acute pancreatitis ; Therapy ; Dextran ; Hypertonic ; Colloid ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: Ultrahigh-molecular dextran (500000 Da) has been shown to prevent pancreatic necrosis when given 30 min after induction of pancreatitis. This study should clarify the following: (a) are dextrans still effective after prolongation of the therapy-free interval? (b) what is the impact of the molecular weight of the dextrans? and (c) is their effect influenced by the dextran concentration or by the addition of hypertonic saline? Animals and interventions: Acute pancreatitis was induced in 70 male dextran-tolerant Wistar rats using intraductal bile-salt infusion and intravenous hyperstimulation. After 3 h, animals were assigned to one of seven groups (n=10 per group) receiving either Ringer solution or different dextrans (10%) including 70000 Da (DEX-70), 160000 Da (DEX-160), 300000 Da (DEX-300) or 500000 Da (DEX-500). Additional groups included DEX-70 (6%) and DEX-70 (10%) in combination with hypertonic NaCl (7.5%) (HHS-70). Ringer solution was given at 24 ml/kg and all dextrans at 8 ml/kg. Measurements and results: Trypsinogen activation peptides (TAP) were quantified in ascites and acinar necrosis after death or sacrifice at 9 h. As an index of less pathological trypsinogen activation, the mean TAP levels in ascites were significantly lower in DEX-70 and DEX-160 compared to Ringer controls (p〈0.05, t-test). Furthermore, the amount of acinar necrosis was significantly lower in all dextran groups except the HHS-70 in comparison with Ringer controls (p〈0.01, t-test). Finally, mortality was significantly reduced from 60% in Ringer controls to 10 and 0%, respectively, in the groups treated with DEX-70 and DEX-160 (p〈0.03, Fisher‘s Exact test). There was a similar trend in all other groups except the HHS-70. Conclusions: Despite a therapy-free interval of 3 h, dextrans reduce trypsinogen activation, prevent acinar necrosis, and improve survival in necrotizing rodent pancreatitis. The molecular weight and concentration of dextran are of secondary importance for these beneficial effects.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Journal of chemical ecology 23 (1997), S. 1929-1939 
    ISSN: 1573-1561
    Schlagwort(e): (Z)-11-Eicosen-1-ol ; octadecanol ; eicosanol ; docosenol ; alarm pheromone ; venom ; Apis cerana ; Apis koschevnikovi ; Apis dorsata ; Apidae ; Hymenoptera
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The unusual venom of Apis cerana contains large oily droplets within an otherwise aqueous secretion. Chemical analysis (GC-MS) revealed that the venom oil consists of (Z)-11-eicosen-1-ol (81.2%), other linear alcohols (7.7%), and linear hydrocarbons (11.1%). The eicosenol is present in extremely large quantities, averaging over 250 μg per insect, and is absent, or present in small quantities, in other parts of the sting apparatus. An investigation of the site of eicosenol storage in A. mellifera showed it to be absent from the venom and to be associated with the setose area where the more volatile components of the alarm pheromone are stored, as previously shown by others. A third honeybee species, A. dorsata, does not to contain the alcohol. The function of eicosenol in A. cerana in not clear, but may serve to mark stung intruders with pheromone or to attract foragers to marked floral resources.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1573-0794
    Schlagwort(e): 07.03.2 Comet C/1995 O1:Hale–Bopp ; 13.18.4
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract The concept of simultaneous multifrequency continuum observations, successfully tested on Comet Hyakutake, was applied to Comet Hale-Bopp, using the Heinrich Hertz Submillimeter Telescope (HHT) with the four color bolometer between 250 and 870 GHz, the IRAM 30m telescope at 240 Ghz, the MPIfR 100-m telescope at 32 GHz, and the IRAM interferometer near 90 and 240 GHz. Near-simultaneous measurements were done between February 15 and April 26, 1997, mainly concentrated in mid March shortly before perigee of the comet. The measurements gave the following preliminary results: Interferometer detection of the nuclear thermal emission. If the signal at the longest interferometer spacing of 170 mis due to thermal emission from the nucleus only, its equivalent diameter is ∼49 km. If, however, this signal contains a contribution from a strongly centrally peaked halo distribution(e.g., r−2 density variation) the diameter may be as low as 35 km. The emission found interferometrically was always 5″ north and 0.1 sec east from the position predicted by Yeoman's solution 55.The comparison of the interferometric continuum emission with the simultanously obtained molecular line observations (reported on this conference) shows the origin of the strongest line emission concentrated on the nucleus. The 30-m observations show a radio halo with a gaussian FWHP of ∼11, corresponding to a diameter of 11000 km at geocentric distance of 1.2 a.u. A spectral index of ∼3.0 for the total signal, which may indicate a smaller mean particle size than for Hyakutake. Assuming an average cometary density of 0.5 gcm−3, the mass contained in the nucleus is ∼1$#x2013;3 1019 g and 1012 g in the particle halo.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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