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  • 1995-1999  (4)
  • 21.10.-k  (1)
  • Key words: Liver, MR—Liver neoplasms, MR—Liver neoplasms, diagnosis—Magnetic resonance (MR), contrast enhancement—Bile ducts, neoplasms.  (1)
  • Keywords Ovarian hormones  (1)
  • MR imaging  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Ovarian hormone-induced beta-cell hypertrophy contributes to the homeostatic control of beta-cell mass in OLETF female rat, a model of Type II diabetes (1998)
    Springer
    Diabetologia 41 (1998), S. 799-805 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Keywords Ovarian hormones ; beta-cell ; hypertrophy ; pancreatectomy ; OLETF rat.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A sexual dimorphism regarding the incidence of diabetes mellitus in OLETF rat, a model of Type II diabetes, has been reported. As a result, the effects of ovarian hormones on beta cells per se was examined by comparing the capacity of beta-cell proliferation and changes in blood glucose and plasma insulin concentrations after a 70 % pancreatectomy. All female animals were randomly assigned to two protocols. The rats involved in protocol I received either a 70 % pancreatectomy (Px) or a sham pancreatectomy (sham) at 6 weeks of age, along with their diabetes-resistant counterparts, female LETO rats, which served as normal controls. The rats belonging to protocol II were given an ovariectomy (Ox) at 5 weeks of age, and one week later, they were subjected to either Px or the sham operation, with/without hormone (estradiol, 50 μg/kg; testosterone, 1 mg/kg) replacement. The findings indicate that the capacity for compensatory growth of beta cells after Px was affected by both sex hormonal and genetic components, since a 70 % Px resulted in sustained hyperglycaemia within the first week after surgery, but was ameliorated by an increase in beta-cell mass thereafter in the non-Ox Px OLETF rats. The Ox also caused a decline in beta-cell mass which could be improved by replacement with ovarian hormones. Not only endogenous but also replacement ovarian hormones, led to a beneficial effect on beta cells per se in OLETF female rats. This was reflected by an increased beta-cell mass accompanied by a parallel increase in plasma immunoreactive insulin concentration. The effects of ovarian hormones, however, contributed to the beta-cell hypertrophy rather than expansion of the beta-cell population to achieve glucose homeostasis, as evidenced by an increased area of individual beta-cell after Px rather than an increased BrdU-labelling index for the beta cells. The present study suggests that ovarian hormone-induced beta-cell hypertrophy may typically occur, to compensate for changes in functional demand as the results of a 70 % Px in female OLETF rats. [Diabetologia (1998) 41: 799–805]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001250050990
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  • 2
    Digitale Medien
    Digitale Medien
    MR imaging patterns of gadolinium retention within liver neoplasms (1998)
    Springer
    Abdominal imaging 23 (1998), S. 592-599 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Key words: Liver, MR—Liver neoplasms, MR—Liver neoplasms, diagnosis—Magnetic resonance (MR), contrast enhancement—Bile ducts, neoplasms.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Background: To determine the spectrum of appearances of gadolinium retention within cholangiocarcinoma (CCA) and other liver neoplasms. Methods: Two hundred ten patients underwent hepatic magnetic resonance imaging (MRI) at 1.5 T with precontrast T1- and T2-weighted spin-echo (SE) images and delayed Gd-DTPA- or gadoteridol- (0.1 mmol/kg) enhanced T1-weighted SE images. Postcontrast images were evaluated for lesions suspicious for tumors, and lesion signal intensity was characterized as homogeneously or heterogeneously hypo-, iso-, mildly hyper-, or markedly hyperintense to liver. Data from 94 patients with benign or malignant neoplasms are presented. Results: Imaging demonstrated 237 malignant neoplasms (121 hepatocellular carcinoma [HCC], 26 CCA, 17 colon carcinoma metastases, 73 other tumors) and 28 benign neoplasms (22 hemangioma, six focal nodular hyperplasia [FNH]). One hundred forty malignant lesions appeared as homogeneous postcontrast (29 hypointense, 75 isointense, 17 mildly hyperintense, 19 markedly hyperintense) and 97 as heterogeneous (15 isointense, 50 mildly hyperintense, 32 markedly hyperintense). Malignant lesions showing homogeneous, mildly or markedly hyperintense signal intensity postcontrast included 10 CCA, seven HCC, six epithelioid hemangioendothelioma, eight neuroendocrine tumor metastases, three adenocarcinoma metastases of unknown origin, and one breast carcinoma metastasis. Hemangiomas appeared as homogeneous postcontrast in 19 lesions (six isointense, one mildly hyperintense, 12 markedly hyperintense) and as heterogeneous in three lesions (markedly hyperintense). FNH appeared as homogeneous postcontrast in one lesion (isointense) and as heterogeneous in five lesions (one isointense, four mildly hyperintense). Conclusion: Homogeneous gadolinium retention on delayed postcontrast images of malignant hepatic neoplasms is seen in a high percentage of CCA lesions and less commonly with other neoplasms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002619900410
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  • 3
    Digitale Medien
    Digitale Medien
    MR imaging of non-squamous vaginal tumors (1999)
    Springer
    European radiology 9 (1999), S. 1214-1218 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Key words: Vagina ; Non-squamous vaginal neoplasms ; MR imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. We reviewed the MR images and pathologic findings of five cases of primary vaginal neoplasms of non-squamous origin. Histologic types consisted one case each of adenocarcinoma, adenosarcoma, melanoma, lymphoma, and neurilemoma. Magnetic resonance imaging was found useful for evaluating the type and the extension of vaginal tumors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003300050820
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  • 4
    Digitale Medien
    Digitale Medien
    High-spin states in148Tb (1995)
    Springer
    The European physical journal 352 (1995), S. 363-364 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 21.10.-k ; 27.60.+j
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract High-spin states of148Tb were studied by inbeam γ-ray spectroscopic techniques using141Pr(13C,6n)148Tb and27Al(130Te,9n)148Tb reactions. The level scheme of148Tb was established up to the excitation energy of 11.8MeV. The excitation energy of the high-spin isomer reported previously was revised to be 8.620MeV. The excited states below the isomer could be understood as resulted from the weak couplings of πh11/2 and νf7/2 to those of147Gd and147Tb, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01299753
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