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  • 1
    Electronic Resource
    Electronic Resource
    Detection of lysyl oxidase gene expression in rat skin during wound healing (1995)
    Springer
    Archives of dermatological research 288 (1995), S. 7-10 
    Details
    ISSN: 1432-069X
    Keywords: Key words Lysyl oxidase ; Gene expression ; Wound healing ; Type III collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lysyl oxidase (LOX) initiates the crosslinking of the lysine-derived aldehyde and plays an essential role in maturation of collagen, for example in wound healing. Although the activity of this enzyme has been examined in various disorders, and a further intriguing aspect of the relationship between LOX and tumorigenesis has recently emerged, its gene expression pattern in tissues is still unknown. We examined LOX gene expression during wound healing in rat skin. In addition, type III collagen gene expression was studied to determine the formation of fibrils. The LOX mRNA level reached a peak by day 3 after injury, which was earlier than that of type III collagen, and continued at a high level until day 22. The type III collagen mRNA level began to rise from day 3 and had increased intensely by day 22. In situ hybridization revealed grains corresponding to LOX mRNA in the fibroblasts of the granulomatous tissue. These results suggest that LOX is produced before collagen synthesis in preparation for crosslinking in the early phase of wound healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050014
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of single-dose intravenous amikacin in critically ill patients undergoing slow hemodialysis (1995)
    Springer
    Intensive care medicine 21 (1995), S. 348-351 
    Details
    ISSN: 1432-1238
    Keywords: Amikacin ; Pharmacokinetics ; Slow hemodialysis ; Renal failure ; Critically ill patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The pharmacokinetics of amikacin were studied in patients undergoing slow hemodialysis (HD). Design Slow HD was performed at the dialysate flow rate of 30 ml/min. After a single intravenous dose of amikacin 5 mg/kg, pharmacokinetic variables were calculated by fitting indivdual concentration-time curves to a two-compartment open model. Patients 6 critically ill patients with renal failure were entered into the study. Results The volume of distribution was 0.35±0.03 l/kg. Total body clearance was 35.1±2.3 ml/min with an elimination half-life of 10.5 h. During a 10.5 h session of slow HD, the serum amikacin concentration decreased from the peak level of 21.3±1.2 mg/l to 7.2±0.9 mg/l. Conclusion Slow HD eliminate amikacin more efficiently than other types of slowly performed renal replacement therapy and had profound effects on the pharmacokinetics. Amikacin elimination by this approach should be taken into consideration for designing a dosage schedule during the treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705414
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Amino acid losses and nitrogen balance during slow diurnal hemodialysis in critically ill patients with renal failure (1997)
    Springer
    Intensive care medicine 23 (1997), S. 110-113 
    Details
    ISSN: 1432-1238
    Keywords: Key words Amino acid ; Nitrogen balance ; Slow hemodialysis ; Critically ill ; Renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The effects of slow diurnal hemodialysis (slow HD) on amino acid losses and nitrogen balance were studied. Design: Slow HD was conducted for 10 h during the day at the dialysate flow rate of 30 ml/min. The patients received total parenteral nutrition including 40 g of amino acids (6.08 g of nitrogen). The amino acid concentrations in plasma and dialysate were determined and the daily nitrogen balance was calculated from the urea nitrogen appearance. Patients: Six critically ill patients with renal failure were entered into the study. Results: Slow HD eliminated 48.5±4.4 mmol (6.2±0.6 g) of amino acids, representing 16% of the daily amino acid load. The estimated nitrogen balance was –2.3±1.3 g/day. Amino acid nitrogen lost in the dialysate was 1.0±0.1 g, contributing 43% of the daily negative nitrogen balance. Conclusion: The amount of amino acid losses during slow HD should be taken into consideration when designing nutritional schedules for maintaining positive nitrogen balance in critically ill patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050299
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    Paper (German National Licenses)
    Fulltext
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