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  • 1995-1999  (3)
  • Insulin-like growth factor binding proteins  (1)
  • Keywords Neuropeptide Y  (1)
  • Restrained eating  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Elevated levels of insulin-like growth factor (IGF) binding protein-3 in rheumatoid arthritis synovial fluid inhibit stimulation by IGF-I of articular chondrocyte proteoglycan synthesis (1997)
    Springer
    Rheumatology international 17 (1997), S. 29-37 
    Details
    ISSN: 1437-160X
    Keywords: Key words Insulin-like growth factors ; Insulin-like growth factor binding proteins ; Rheumatoid arthritis ; Articular cartilage ; Proteoglycans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to quantify insulin-like growth factor (IGF) binding proteins (IGFBPs) in the synovial fluid (SF) and plasma of patients with rheumatic diseases and to study the role of these proteins in the regulation of cartilage proteoglycan (PG) synthesis. Immunological determination of IGFBP-2, IGFBP-3, IGF-I, IGF-II, interleukin-1β (IL-1β) and tumour necrosis fac-tor α (TNFα) was undertaken in the SF and plasma of 115 patients with rheumatoid arthritis (RA; n = 53), osteoarthritis (OA; n = 44) and other rheumatic disorders. We also determined the effects of SF on bovine cartilage PG synthesis in culture. IGFBP-2 and IGFBP-3 were elevated in the plasma (by 38% and 28%, respectively) and SF (by 56% and 59%, respectively) of patients with RA compared to age- and sex-matched OA controls (determined by RIA and confirmed by Western ligand blot). IGF-I and IGF-II did not differ significantly between the two groups. OA SF, and, to a lesser extent, RA SF stimulated cartilage PG synthesis in culture, and more than 60% of this activity was neutralised by a specific monoclonal anti-IGF-I antibody. Human IGFBP-3 dose-dependently inhibited the stimulation of cartilage PG synthesis effected by SF or human IGF-I. In RA patients, the SF concentration of IGFBP-3 was positively correlated with SF levels of IL-1β and TNFα, with the serum level of C-reactive protein and with the erythrocyte sedimentation rate. We concluded that IGF-I is, under the conditions studied, the most important anabolic factor in human SF with respect to articular cartilage PG synthesis. The bioactivity of IGF-I in joints is modulated by IGFBP-3, which is elevated in RA SF compared to OA SF. Elevated IGFBP-3 in RA SF may reduce the availability of IGF-I to articular chondrocytes, thus interfering with cartilage PG synthesis in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006847
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Gewichtsregulation im Rahmen der Anorexia nervosa unter besonderer Berücksichtigung der Leptinsekretion (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 31-40 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Body Mass Index ; Untergewicht ; Amenorrhö ; gezügeltes Eßverhalten ; Konstitutionslehre ; Key words Body mass index ; Underweight ; Amenorrhea ; Restrained eating ; Body frame
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Underweight is a key symptom in anorexia nervosa. In this review we summarize recent findings pertaining to weight regulation in this eating disorder. The observation that a body mass index below 13 kg/m2 upon admission for inpatient treatment is associated with a high mortality rate and chronic persistence of underweight is of obvious clinical relevance. A lowered leptin secretion, which results from the weight loss, is presumably of major importance for the development of amenorrhea. We discuss findings pertaining to a reduced body weight in other psychiatric disorders during adolescence in the light of Kretschmer’s findings related to body frame and psychopathology.
    Notes: Zusammenfassung Untergewicht ist ein Leitsymptom der Anorexia nervosa. In dieser Übersicht fassen wir neuere Untersuchungen zur Gewichtsregulation im Rahmen dieser Eßstörung zusammen. Klinisch relevant ist die Beobachtung, daß ein Body Mass Index von unter 13 kg/m2 zum Zeitpunkt der Aufnahme in eine stationäre Behandlung mit einer erhöhten Mortalität und dem langfristigen Fortbestehen von Untergewicht assoziiert ist. Eine erniedrigte Leptinsekretion, die als Folge der Gewichtsabnahme entsteht, ist mutmaßlich für das Auftreten der ebenfalls charakteristischen Amenorrhö von zentraler Bedeutung. Wir diskutieren Befunde, die auf das gehäufte Vorkommen von Untergewicht auch bei anderen psychiatrischen Störungen im Jugendalter hinweisen vor dem Hintergrund der Konstitutionslehre von Kretschmer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050398
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of intravenous neuropeptide Y on insulin secretion and insulin sensitivity in skeletal muscle in normal rats (1998)
    Springer
    Diabetologia 41 (1998), S. 1361-1367 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Neuropeptide Y ; insulin secretion ; insulin sensitivity ; leptin ; clamp technique ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracerebroventricular administration of neuropeptide Y to normal rats induces a syndrome characterised by obesity, hyperinsulinaemia, insulin resistance and over expression of the adipose tissue ob gene. Little is known about the effect of circulating neuropeptide Y on glucose metabolism, insulin secretion and leptin. We therefore aimed to evaluate the effect of an intravenous infusion of neuropeptide Y on glucose disposal, endogenous glucose production, whole body glycolytic flux, and glucose storage as assessed during euglycaemic hyperinsulinaemic clamp. In addition, the insulin-stimulated glucose utilisation index in individual tissues was measured by the 2-deoxy-[1-3H]-glucose technique. The effect of neuropeptide Y on insulin secretion was evaluated by hyperglycaemic clamp. Infusion did not induce any change in endogenous glucose production during basal conditions or at the end of the clamp. Glucose disposal was significantly increased in the rats given neuropeptide Y compared with controls (27.8 ± 1.3 vs 24.3 ± 1.6 mg · min–1· kg–1; p 〈 0.05) as was the glycolytic flux (18.9 ± 1.6 vs 14.4 ± 0.8 mg · min–1· kg–1; p 〈 0.05), while glucose storage was comparable in the two groups. In skeletal muscle, the glucose utilisation index was increased significantly in rats given neuropeptide Y. The glucose utilisation index in subcutaneous and epididimal adipose tissue was not significantly different between the two groups. Plasma leptin was significantly increased by hyperinsulinaemia, but was not affected by neuropeptide Y infusion. Both the early and late phase of the insulin response to hyperglycaemia were significantly reduced by neuropeptide Y. In conclusion neuropeptide Y infusion may increase insulin-induced glucose disposal in normal rats, accelerating its utilisation through the glycolytic pathway. Neuropeptide Y reduces both phases of the insulin response to hyperglycaemia. [Diabetologia (1998) 41: 1361–1367]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051077
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    Paper (German National Licenses)
    Fulltext
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