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  • 1990-1994  (5)
  • 1985-1989  (17)
  • Polymer and Materials Science  (19)
  • Neurone number  (2)
  • Pharmacokinetics
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Pharmakokinetik und Pharmakodynamik von Theophyllin bei multimorbiden geriatrischen Patienten (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 551-557 
    Details
    ISSN: 1432-1440
    Keywords: Theophylline ; Age ; Multimorbidity ; Pharmacokinetics ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of theophylline (200 mg i.v.) were determined in 20 geriatric patients with multiple diseases. Serum concentrations were fitted to an open 2-compartment model. Percent changes in venous pCO2 and pO2 were used as parameters of the pharmacodynamic action. Total clearance was decreased and elimination half-life of theophylline was found to be prolonged in the elderly patients compared with data of a study with young healthy volunteers. The stronger the pharmacodynamic action of theophylline (percent change of venous pCO2 after 30 min), the faster was its elimination and the lower were measured concentrations after 2, 6, and 12 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727621
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  • 2
    Electronic Resource
    Electronic Resource
    Cortical and striatal neurone number in Huntington's disease (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 320-333 
    Details
    ISSN: 1432-0533
    Keywords: Key words Huntington's disease ; Human cerebral cortex ; Striatum ; Neurone number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The total cortical and striatal neurone and glial numbers were estimated in five cases of Huntington's disease (three males, two females) and five age- and sex-matched control cases. Serial 500-μm-thick gallocyanin-stained frontal sections through the left hemisphere were analysed using Cavalieri's principle for volume and the optical disector for cell density estimations. The average cortical neurone number of five controls (mean age 53±13 years, range 36 – 72 years) was 5.97×109±320×106, the average number of small striatal neurones was 82×106±15.8×106. The left striatum (caudatum, putamen, and accumbens) contained a mean of 273×106±53×106 glial cells (oligodendrocytes, astrocytes and unclassifiable glial profiles). The mean cortical neurone number in Huntington's disease patients (mean age 49±14 years, range 36 – 75 years) was diminished by about 33  % to 3.99×109±218×106 nerve cells (P≤ 0.012, Mann-Whitney U-test). The mean number of small striatal neurones decreased tremendously to 9.72 × 106± 3.64×106 ( – 88  %). The decrease in total glial cells was less pronounced (193 × 106±26 × 106) but the mean glial index, the numerical ratio of glial cells per neurone, increased from 3.35 to 22.59 in Huntington's disease. Qualitatively, neuronal loss was most pronounced in supragranular layers of primary sensory areas (Brodmann's areae 3,1,2; area 17, area 41). Layer IIIc pyramidal cells were preferentially lost in association areas of the temporal, frontal, and parietal lobes, whereas spared layer IV granule cells formed a conspicuous band between layer III and V in these fields. Methodological issues are discussed in context with previous investigations and similarities and differences of laminar and lobar nerve cell loss in Huntington's disease are compared with nerve cell degeneration in other neuropsychiatric diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310376
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  • 3
    Electronic Resource
    Electronic Resource
    Cortical and striatal neurone number in Huntington's disease (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 320-333 
    Details
    ISSN: 1432-0533
    Keywords: Huntington's disease ; Human cerebral cortex ; Striatum ; Neurone number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The total cortical and striatal neurone and glial numbers were estimated in five cases of Huntington's disease (three males, two females) and five age-and sex-matched control cases. Serial 500-μm-thick gallocyanin-stained frontal sections through the left hemisphere were analysed using Cavalieri's principle for volume and the optical disector for cell density estimations. The average cortical neurone number of five controls (mean age 53±13 years, range 36–72 years) was 5.97×109±320×106, the average number of small striatal neurones was 82×106±15.8×106. The left striatum (caudatum, putamen, and accumbens) contained a mean of 273×106±53×106 glial cells (oligodendrocytes, astrocytes and unclassifiable glial profiles). The mean cortical neurone number in Huntington's disease patients (mean age 49±14 years, range 36–75 years) was diminished by about 33% to 3.99×109±218×106 nerve cells (P≦0.012, Mann-Whitney U-test). The mean number of small striatal neurones decreased tremendously to 9.72×106±3.64×106 (−88%). The decrease in total glial cells was less pronounced (193×106±26×106) but the mean glial index, the numerical ratio of glial cells per neurone, increased from 3.35 to 22.59 in Huntington's disease. Qualitatively, neuronal loss was most pronounced in supragranular layers of primary sensory areas (Brodmann's areae 3,1,2; area 17, area 41). Layer IIIc pyramidal cells were preferentially lost in association areas of the temporal, frontal, and parietal lobes, whereas spared layer IV granule cells formed a conspicuous band between layer III and V in these fields. Methodological issues are discussed in context with previous investigations and similarities and differences of laminar and lobar nerve cell loss in Huntington's disease are compared with nerve cell degeneration in other neuropsychiatric diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310376
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Analytik von Prepolymeren und Polymeren aromatischer Cyansäureester. 2. Hochdruckflüssigchromatographie (1986)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 37 (1986), S. 221-223 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Separation of oligomeric trimerisates of difunctional aromatic cyanic acid esters is shown to be possible by the HPLC-gradient-elution-technique in THF/H2O on RP8-modified silicagel phases. The stepgrowth mechanism of the polycyclotrimerisation reaction was supported by quantitative analysis.
    Notes: Durch Gradientenelution in THF/H2O an RP8-modifizierten Kieselgel-Phasen gelingt eine Auftrennung oligomerer Trimerisate difunktioneller aromatischer Cyansäureester. Der Stufenmechanismus der Polycyclotrimerisierung wird durch quantitative Auswertung bestätigt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1986.010370409
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  • 5
    Electronic Resource
    Electronic Resource
    Thermischer und thermisch-oxidativer Abbau von Polycyanuraten und deren Kombinationen mit Polyglycidethern (1987)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 658-661 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: By investigations of the thermal and thermal oxidative behaviour of polycyanurates and their blends with polyglycidethers is demonstrated that polymers prepared from nearly equimolar ratios of cyanate and glycidylether groups show minimum stability, while the pure polycyanurates show maximum stability.
    Notes: Untersuchungen zur thermischen und thermisch-oxidativen Beständigkeit von Polycyanuraten und deren Modifizierungen mit Polyglycidethern zeigten, daß Polymere aus nahezu äquivalenten Anteilen an Cyanat- und Glycidether-Gruppen die geringste und reine Polycyanurate die höchste Stabilität aufweisen.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1987.010381205
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  • 6
    Electronic Resource
    Electronic Resource
    Reaktionen polyfunktioneller Cyansäureester mit polyfunktionellen Glycidethern. 1. Identifizierung der gebildeten StrukturelementeHerrn Professor Dr. Dr. h. c. Hermann Klare zum 80. Geburtstag gewidmet (1989)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 40 (1989), S. 335-340 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The chemical structures formed at the reaction of glycidylethers with aromatic cyanates were identified. In dependence on the molar ratio of the monomers, different parts of triazines, alkylisocyanurates, oxazolidinones, phenols, secondary hydroxyl groups, and double bonds were obtained.
    Notes: Die bei der Reaktion von Glycidethern und aromatischen Cyansäureestern gebildeten chemischen Strukturen wurden identifiziert. In Abhängigkeit vom Stoffmengenverhältnis der Monomere wurden unterschiedliche Anteile an Triazinen, Alkylisocyanuraten, Oxazolidinonen, Phenolen, sekundären Hydroxylgruppen und Doppelbindungen erhalten.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1989.010400509
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  • 7
    Electronic Resource
    Electronic Resource
    Remark on the approximate character of the kinetic/structural model for the cyanate-epoxy network build-up (1989)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 40 (1989), S. 679-680 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1989.010401016
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Analytik von Prepolymeren und Polymeren aromatischer Cyansäureester. 3. Differential Scanning CalorimetrieTeil 2: Acta Polymerica 37 (1986) 221-223. (1986)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 37 (1986), S. 604-606 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: By DSC-experiments with constant heating rate or under isothermal conditions the complex character of the thermal polycyclotrimerisation of 2,2-bis(4-cyanatophenyl)propane in bulk is shown. An activation energy of 80 kJ/mol for the first order brutto kinetics is calculated by several methods.
    Notes: Aus DSC-Messungen mit konstanter Heizrate und unter isotherman Bedingungen wird der komplexe Charakter der thermischen Polycyclotrimerisierung von 2,2-Bis(4-cyanatophenyl)propan in der Schmelze ersichtlich. Für die Bruttoreaktion 1. Ordnung wird nach verschiedenen Auswertemethoden eine Aktivierungsenergie von 80 kJ/mol erhalten.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1986.010371002
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  • 9
    Electronic Resource
    Electronic Resource
    Analytik von Prepolymeren und Polymeren aromatischer Cyansäureester. 4. TitrationsmethodeTeil 3: Acta Polymerica 37 (1986) 604 (1986)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 37 (1986), S. 654-654 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1986.010371013
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  • 10
    Electronic Resource
    Electronic Resource
    Reine und modifizierte Polycyanurate als Elektroisolierstoffe (1987)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 393-396 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The electrical properties of polycyanurates and their modifications with polyglycidylether are described. The usefulness of these polymers as excellent electrical insulation materials is demonstrated by two examples.
    Notes: Elektrische Eigenschaften reiner und mit Polyglycidethern modifizierter Polycyanurate werden aufgezeigt. An zwei Beispielen wird der Einstatz von Diandicyanat-Dianbisglycidether-Kombinationen als Elektroisolierstoff beschreieben.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1987.010380618
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