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  • 1990-1994  (8)
  • cerebrospinal fluid  (5)
  • Magnetic resonance imaging  (2)
  • vascular dementia of the Binswanger type  (2)
  • CT  (1)
  • (Mastocytoma P-815 cell)
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The effect of age on concentrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 215-226 
    Details
    ISSN: 1435-1463
    Keywords: Monoamines ; amino acid ; purine metabolites ; cerebrospinal fluid ; aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied age-related changes in the concentrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid on 144 neurologically normal subjects. The concentrations of tyrosine, 3-O-methyldopa, dopamine (total), norepinephrine (total), homovanillic acid, p-hydroxyphenylacetic acid, and 5-hydroxytryptophan increased significantly with age (p〈0.05), and the concentration of 3.4-dihydroxyphenylacetic acid displayed a non-significant trend to decrease, whereas concentrations of other monoamine precursors and metabolites were unchanged. We found the significant positive correlations between the concentrations of HVA and 5-HIAA (p〈0.001), between tyrosine and tryptophan (p〈0.001), and between tyrosine and 3-O-methyldopa (p〈0.001). The concentrations of asparagine, glycine, taurine, and alanine increased significantly with age (p〈0.05), while glutamine, arginine, and threonine concentrations did not change with age. The aspartate, glutamate, and GABA concentrations displayed the non-significant trends to decrease in the elderly subjects. The concentrations of aspartate, glutamate, and GABA had mutually significant positive correlations (p〈0.05), but had significant negative correlations with the concentrations of some neutral amino acids. The urate and xanthine concentrations increased significantly with age (p〈0.01). These findings suggest that the concentrations of monoamine and amino acid transmitters and their related compounds in the cerebrospinal fluid reflect age-related changes in the synthesis, release, and reuptake mechanisms of the transmitters and their transport mechanisms across the blood-brain barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257676
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 27-34 
    Details
    ISSN: 1435-1463
    Keywords: L-threo-DOPS ; freezing of gait ; norepinephrine ; dopamine ; cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the effects of L-threo-DOPS (L-DOPS) on the concentrations of total (conjugated and unconjugated) dopamine (DA) and norepinephrine (NE) in the cerebrospinal fluid (CSF) of parkinsonian patients with freezing phenomenon. The NE concentration increased remarkably and dose-dependently after administration of L-DOPS in both L-dopa/carbidopa-pretreated and untreated patients. The DA concentration also increased mildly but significantly in L-dopa/carbidopa-untreated patients. Freezing phenomenon improved in 6 out of 8 patients at Hoehn and Yahr's stage III, and 1 out of 5 patients at stage IV. These results indicate that L-DOPS administration increases the NE concentration dosedependently, and is effective for freezing of gait of moderate severity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260912
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Monoamine metabolism in the cerebrospinal fluid in Parkinson's disease: relationship to clinical symptoms and subsequent therapeutic outcomes (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 17-26 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; monoamines ; cerebrospinal fluid ; L-dopa ; freezing of gait
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We correlated monoamine concentrations in the cerebrospinal fluid from de novo (untreated) patients with Parkinson's disease with their clinical symptoms and therapeutic outcome after two years of L-dopa with/without other anti-parkinson medication. A significant correlation was found between the severity of some parkinsonian symptoms and the reduction in particular monoamines: Hoehn and Yahr's stage with dopamine, norepinephrine, and homovanillic acid: rigidity with dopamine; akinesia with dopamine and norepinephrine; freezing of gait with norepinephrine; and dementia with dopamine and homovanillic acid. Tremor had no correlations with the concentrations of the monoamines measured. Patients with dementia had a significantly increased level of epinephrine concentrations. Insufficient therapeutic responses of invidividual symptoms were associated with significantly decreased concentrations of particular monoamines before treatment: Hoehn and Yahr's stage with norepinephrine and epinephrine; akinesia with homovanillic acid and 5-hydroxyindoleacetic acid; and freezing of gait with dopamine, norepinephrine, homovanillic acid, and 5-hydroxyindoleacetic acid. These results suggest a significant correlation between the reduction in particular monoamines and the severity of some parkinsonian symptoms and their subsequent responses to L-dopa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260911
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinson's disease (1993)
    Springer
    Journal of neural transmission 6 (1993), S. 119-126 
    Details
    ISSN: 1435-1463
    Keywords: Urate ; xanthine ; vascular dementia of the Binswanger type ; Alzheimer type dementia ; Parkinson's disease ; cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We determined the urate and xanthine concentrations in the cerebrospinal fluid (CSF) in patients with vascular dementia of the Binswanger type (VDBT), Alzheimer type dementia (ATD), and Parkinson's disease (PD). We found that the urate concentration was significantly increased in VDBT patients, but significantly decreased in ATD patients compared with controls. The ratio of the concentrations of uric acid (UCSF) to xanthine (XCSF) in the CSF (UCSF/XCSF) had a significant correlation with the ratio of the UCSF to the urate concentration in serum (Userum) (UCSF/Userum) in ATD and PD, whereas UCSF/Userum increased independently of UCSF/XCSF in VDBT. We concluded that the significant increase in the urate concentration in VDBT is mainly due to an impairment of the blood-brain barrier (BBB), and its significant reduction in ATD may reflect impaired brain metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261005
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  • 5
    Electronic Resource
    Electronic Resource
    MRI of anterior spinal artery syndrome of the cervical spinal cord (1992)
    Springer
    Neuroradiology 35 (1992), S. 25-29 
    Details
    ISSN: 1432-1920
    Keywords: Anterior spinal artery syndrome ; Cervical spinal cord ; Infarct ; Magnetic resonance imaging ; Spinal angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cervical spinal cord lesions in the anterior spinal artery syndrome were delineated on magnetic resonance images (MRI) in four patients. The lesion was always seen anteriorly in the cervical cord. On T2-weighted images, the lesions appeared hyperintense relative to the normal spinal cord, while on T1-weighted images, two chronic lesions appeared hypointense, with local atrophy of the cord. In one case, repeated T1-weighted images showed no signal abnormality 4 days after the ictus, but the lesion became hypointense 18 days later, when contrast enhancement was also recognized after injection of Gd-DTPA; this sequence of intensity changes was similar to that of cerebral infarction. The extent of the lesion seen MRI correlated closely with neurological findings in all cases. Although the findings may not be specific, MRI is now the modality of choice for confirming the diagnosis in patients suspected of having an anterior spinal artery syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588273
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Cranial MRI and MR angiography in Menkes' syndrome (1993)
    Springer
    Neuroradiology 35 (1993), S. 556-558 
    Details
    ISSN: 1432-1920
    Keywords: Menkes' syndrome ; Magnetic resonance imaging ; Magnetic resonance angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two boys with Menkes' syndrome who underwent cranial MRI and MR angiography (MRA). In both, CT and MRI revealed progressive cerebral atrophy with a subdural haematoma or effusion. Delayed myelination or dysmyelination of the white matter was suggested. Tortuosity of the cervical and intracranial vessels was well demonstrated by MRA, obviating more invasive conventional angiography should it be thought necessary to demonstrate the characteristic systemic vascular changes of this syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588724
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  • 7
    Electronic Resource
    Electronic Resource
    The anterior choroidal artery syndrome (1994)
    Springer
    Neuroradiology 36 (1994), S. 340-345 
    Details
    ISSN: 1432-1920
    Keywords: Infarcts, anterior choroidal artery ; CT ; MRI ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed 12 cases of infarcts in the territory of the anterior choroidal artery (AChA) on CT and/or MRI. In each case vascular occlusion in the region was verified angiographically. Although the extent of the lesion on CT/MR images was variable, all were located on the axial images within an arcuate zone between the striatium anterolaterally and the thalamus posteromedially. The distribution of the lesions on mutiplanar MRI conformed well to the territory of the AChA demonstrated microangiographically. The variability of the extent of the infarcts may be explained by variations in the degree of occlusive changes in the AChA or the development of collateral circulation through anastomoses between the AChA and the posterior communicating and posterior cerebral arteries. The extent of the lesion appeared to be closely related to the degree of neurological deficit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00612114
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Concentration of monoamines and their metabolites in the cerebrospinal fluid from patients with senile dementia of the Alzheimer type and vascular dementia of the Binswanger type (1992)
    Springer
    Journal of neural transmission 4 (1992), S. 69-77 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine ; norepinephrine ; cerebrospinal fluid ; senile dementia of the Alzheimer type ; vascular dementia of the Binswanger type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured the concentrations of total (conjugated and unconjugated) monoamines (dopamine, DA; norepinephrine, NE) and monoamine metabolites (homovanillic acid, HVA; 3-methoxy-4-hydroxyphenyleneglycol, MHPG; 5-hydroxyindoleacetic acid, 5-HIAA) in the cerebrospinal fluid (CSF), using HPLC-ECD in 11 patients with Alzheimer's disease (AD) or senile dementia of the Alzheimer type (SDAT), 17 patients with vascular dementia of the Binswanger type (VDBT), and 15 controls. In AD/SDAT, there was a significant decrease in the DA concentration and a significant increase in the MHPG concentration. The average NE concentration was not altered, but significantly increased with the progression of intellectual disability. There were no significant changes in HVA and 5-HIAA concentrations. Patients with VDBT showed a significant increase in the DA concentration and a significant decrease in HVA and 5-HIAA concentrations. The DA concentrations increased significantly with the progression of dementia and ventricular enlargement. These results indicate that the noradrenergic and dopaminergic system in particular are altered in AD/SDAT, while the dopaminergic and serotonergic systems are mainly involved in VDBT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257623
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