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  • 1990-1994  (3)
  • Methoxyisobutylisonitrile  (2)
  • muscarinic receptor subtype  (1)
  • Adenylate cyclase
  • 1
    Electronic Resource
    Electronic Resource
    Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 1468-1472 
    Details
    ISSN: 1573-2568
    Keywords: stomach ; human gastric mucosa ; muscarinic receptor subtype ; acid secretion ; glandular M3 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 ±6 fmollmg protein and the tritiated ligand N-methylscopolamine had an affinity of (KD)0.39±0.08 nM (n=11). The M1 receptor selective antagonist pirenzepine and the M2 receptor selective ligand AF-DX 116 had low affinities of 148±32 nM (n=13) and 4043±1011 nM (n=3) KD,respectively. The glandular M3 antagonists hexahydrosiladifenidol and silahexocyclium had high affinities of KD 78±23 nM (n=5) and 5.6±1.8 nM (n=3). The agonist carbachol interacted with a single low-affinity site and binding was insensitive to modulation by guanine nucleotides. Antagonist and agonist binding studies thus showed an affinity profile typical of M3 receptors of the glandular type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540563
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Perioperative myocardial perfusion scintigraphy at rest with technetium 99m methoxyisobutylisonitrile before and after coronary bypass operations (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 99-105 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m ; Methoxyisobutylisonitrile ; Myocardial perfusion scintigraphy ; Coronary bypass operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen patients were examined at rest by technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial scintigraphy 1 day before and 1 week after aorto-coronary bypass operation with planar and single photon emission tomography (SPET) imaging. One day postoperatively, a planar scintigraph in the intensive care unit (ICU) was done. Inter-observer variability was 3.8% for all examinations and for SPET alone, 3.9%. The quality of the planar images taken under emergency conditions in the ICU was quite comparable with those taken under routine conditions. The postoperative myocardial infarction in a patient who died 6 days later could clearly be demonstrated. In 16.2% of all segments which were hypoperfused at rest on preoperative scintigraphy, an amelioration of perfusion could be shown in the 1 st week after the bypass operation.99Tc-MIBI proved to be a useful agent to assess perioperative perfusion, in the ICU as well as under standard conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00950754
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Perioperative myocardial perfusion scintigraphy at rest with technetium 99m methoxyisobutylisonitrile before and after coronary bypass operations (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 99-105 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m ; Methoxyisobutylisonitrile ; Myocardial perfusion scintigraphy ; Coronary bypass operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen patients were examined at rest by technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial scintigraphy 1 day before and 1 week after aorto-coronary bypass operation with planar and single photon emission tomography (SPET) imaging. One day postoperatively, a planar scintigraph in the intensive care unit (ICU) was done. Inter-observer variability was 3.8% for all examinations and for SPET alone, 3.9%. The quality of the planar images taken under emergency conditions in the ICU was quite comparable with those taken under routine conditions. The postoperative myocardial infarction in a patient who died 6 days later could clearly be demonstrated. In 16.2% of all segments which were hypoperfused at rest on preoperative scintigraphy, an amelioration of perfusion could be shown in the 1 st week after the bypass operation. 99Tc-MIBI proved to be a useful agent to assess perioperative perfusion, in the ICU as well as under standard conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175912
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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