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  • 1990-1994  (3)
  • Rheumatoid arthritis  (2)
  • Anti-CD4 monoclonal antibody  (1)
  • Autonomic diabetic neuropathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 176-180 
    Details
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175768
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Investigation of parasympathetic and sympathetic cardiac innervation in diabetic neuropathy: Heart rate variation versus meta-iodo-benzylguanidine measured by single photon emission computed tomography (1994)
    Springer
    Clinical autonomic research 4 (1994), S. 117-123 
    Details
    ISSN: 1619-1560
    Keywords: Autonomic diabetic neuropathy ; Heart rate variation ; MIBG-SPECT ; Thermal thresholds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In diabetic neuropathy disturbed autonomic cardiac innervation is associated with shortened life expectancy. Sympathetic dysfunction is likely to play a role in cases of cardiac death. The quantitative uptake of the radiopharmaceutical iodine-123-meta-iodo-benzylguanidine (MIBG) can be measured by single photon emission computed tomography (SPECT). It is an index of the functional integrity of sympathetic neurones in the heart. The respiratory heart rate variation—as assessed by a computerized device—reflects mainly parasympathetic cardiac innervation. In 25 diabetic patients and 19 healthy subjects MIBG-SPECT and heart rate variation tests were carried out. MIBG scans in all normal subjects showed homogeneous uptake of activity. In 12 out of 25 patients at least two heart rate variation tests were abnormal. MIBG-SPECT was more sensitive (abnormal in 17 out of 25). The lack of correlation between MIBG-SPECT results and spectral analysis of heart rate variation suggest that spectral analysis alone should not be regarded as an indicator of sympathetic cardiac innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01845775
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 156-159 
    Details
    ISSN: 1619-7089
    Keywords: Immunoscintigraphy ; Technetium 99m-labelled antibodies ; CD4-specific (T-lymphocyte) antibodies ; Rheumatoid arthritis ; Localisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P〈0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P 〉 0.01) and only weakly with the late bone scan (P 〉 0.05). According to these data we conclude that99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811445
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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