ISSN:
1612-1112
Keywords:
Chromatography, general
;
Optimization
;
Information theory
;
Kalman filter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary If a peak (j=2) moves along the time axis of a chromatogram with no change in the position τ1 of the other peak (j=1) or in areas A1 and A2, the optimum separation, Řs, is defined as the resolution Rs which provides the maximum information, called FUMI, among all possible positions τ2 of the peak (τ2≥τ1). This paper demonstrates that optimum separation, Řs, of chromatographic peaks critically depends on the peak areas. As the area ratio A2/A1 of overlapped peaks increases, greater separation (higher resolution Rs) is needed to obtain maximum information. The quantitative relationship between Řs and A2/A1 is derived by computer simulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02276246
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