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  • 1990-1994  (2)
  • Insulin-like growth factor binding proteins  (1)
  • Scopolin  (1)
  • [abr] Hepes; N-2-hydroxyethylpiperizine-N'-2-ethane sulfonic acid
  • 1
    Electronic Resource
    Electronic Resource
    Accumulation of scopoletin is associated with the high disease resistance of the hybrid Nicotiana glutinosa x Nicotiana debneyi (1993)
    Springer
    Planta 191 (1993), S. 200-206 
    Details
    ISSN: 1432-2048
    Keywords: Disease resistance ; Nicotiana ; Scopoletin ; Scopolin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The high disease resistance of the amphidiploid hybrid of Nicotiana glutinosa x Nicotiana debneyi is associated with high constitutive levels of two phenolic compounds as analysed by high-performance liquid chromatography. The structures of these two compounds were elucidated by means of gas chromatography-tandem mass spectrometry, fluorescence- and light-spectrophotometry to be those of scopolin and scopoletin. They reached levels of 4 nmol·(g FW)−1 and 35 nmol·(g FW)−1, respectively, in leaf tissues of the hybrid, about 10–50 times the amount found in the parental species. Scopoletin showed a direct antimicrobial activity against Cercospora nicotianae, Phytophthora parasitica var. nicotianae, Pseudomonas syringae pvs. tabaci and syringae and tobacco mosaic virus when added to synthetic growth media, mixed with the inoculum or sprayed onto tobacco plants prior to inoculation. We postulate that the high amount of toxic phenolics in the leaves of the hybrid N. glutinosa x N. debneyi contributes to its high disease resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199750
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Growth hormone treatment in children with preterminal chronic renal failure: No adverse effect on glomerular filtration rate (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 601-607 
    Details
    ISSN: 1432-1076
    Keywords: Chronic renal failure ; Recombinant human growth hormone treatment ; Insulin-like growth factors ; Insulin-like growth factor binding proteins ; Progression of renal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Impaired growth and stunting remains a major therapeutic problem in children with chronic renal failure (CRF). Recombinant human growth hormone (rhGH) treatment may be beneficial, but concern has been raised about possible side-effects, i.e. deterioration of renal function and glucose intolerance. We have treated 10 prepubertal children with CRF (median age 7.5 [1.7–10.0] years) with 4 IU rhGH/m2 per day s.c. over a period of 1 year. Height velocity increased significantly (P〈0.03) from basal 4.6 (2.0–14.0) cm/year to 9.7 (6.8–17.6) cm/year. Height velocity SDS for chronological age and for bone age increased in all children from basal median −2.3 to +3.8 (P〈0.005). Median glomerular filtration rate (GFR) measured by single injection inulin clearance at onset was 18 (11–66) ml/min per 1.73 m2 and did not change significantly during the treatment year. The loss of GFR as estimated by creatinine clearance was similar during the treatment year (median loss 1.3 ml/min per 1.73 m2) compared to the year before treatment (median loss 3.7 ml/min per 1.73 m2). Serum glucose levels during an oral glucose tolerance test did not change, but fasting as well as stimulated insulin levels increased significantly with time during the study period. It is concluded that the rhGH regimen employed was remarkably effective in improving growth velocity in children with CRF without adversely affecting GFR. Glucose homeostasis remained stable, but at the expense of increased serum insulin levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957731
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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