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  • 1990-1994  (2)
  • biological activity  (1)
  • glycoprotein  (1)
  • mouse glioma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Distribution of mouse interferon-β in normal and brain tumour-bearing mice (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 46-51 
    Details
    ISSN: 0942-0940
    Keywords: Mouse interferon ; mouse glioma ; pharmacokinetics ; radioassay ; autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of125I-labelled recombinant mouse interferon-β (rMuIFN-β) in normal and glioma (203 glioma) bearing mice was studied by radioassay and macro-autoradiography at 15 and 30 min after a single intravenous injection. The level of rMuIFN-β in the spleen was about 20-fold higher than in serum. Concentrations higher than the serum level was detected in the lung, liver and kidney. The concentration of rMuIFN-β in the brain was 8% of the serum level and the concentration in the glioma 30 min after administration was about 10-fold higher than in normal mouse brain. Macro-autoradiographic study demonstrated a wide distribution range and selective uptake in glioma tissue. Furthermore, we found that mouse gliomas were sensitive to mouse IFN-β. Our findings demonstrate that in the mouse glioma model, intravenously administered interferon reaches the tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405697
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation and characterization of a new hemagglutinin from the red algaGracilaria bursa-pastoris (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 975-977 
    Details
    ISSN: 1420-9071
    Keywords: Marine alga ; agglutinin ; mitogen ; glycoprotein ; sugar-binding specificity ; biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new agglutinin has been isolated from the red algaGracilaria bursa-pastoris by affinity chromatography on a yeast mannan-Cellulofine column. This agglutinin was isolated as a monomeric glycoprotein with a relatively low molecular weight. It had an isoelectric point of 4.7 and contained large amounts of Gly, Asx and Glx. It agglutinated trypsin-treated rabbit erythrocytes at the low concentration of 30 ng/ml. The activity was inhibited only by glycoproteins bearing N-glycans. This agglutinin also showed mitogenic activity for mouse splenic lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939393
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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