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  • 1985-1989  (12)
  • 1980-1984  (7)
  • Chemistry  (15)
  • twins  (2)
  • (Z)-9-nonadecenekw]  (1)
  • Double-blind  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A clinical and pharmacodynamic evaluation of sulpiride (1981)
    Springer
    Psychopharmacology 73 (1981), S. 77-80 
    Details
    ISSN: 1432-2072
    Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431106
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  • 2
    Electronic Resource
    Electronic Resource
    A source of variance in IQ unique to the lower-scoring monozygotic (MZ) cotwin (1986)
    Springer
    Behavior genetics 16 (1986), S. 509-516 
    Details
    ISSN: 1573-3297
    Keywords: twins ; heritability ; environment ; intelligence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Environmental factors more common in twins than singletons appear to be disadvantageous with respect to intelligence. If these factors contribute to within-pair differences in IQ, the effect should be found more in the cotwin lower in IQ (the low twin) than in the cotwin higher in IQ (the high twin). In this case, the variance of the low twins should exceed that of the high twins. This hypothesis was tested for five samples of monozygotic (MZ) twins and three samples of dizygotic (DZ) twins but was confirmed only for the MZ samples. These results suggest that there are disadvantageous environmental factors unique to MZ twins which contribute to within-pair variability. Such factors will cause heritability coefficients obtained using MZ twins to be underestimated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066337
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  • 3
    Electronic Resource
    Electronic Resource
    Estimating true scores in kinship data (1987)
    Springer
    Behavior genetics 17 (1987), S. 487-491 
    Details
    ISSN: 1573-3297
    Keywords: true scores ; measurement error ; kinship data ; twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Estimated true scores are occasionally used to provide an estimate of scores which would be obtained if measurement error could be removed from fallible measures. When one knows only a test's relibility and an observed score for each subject, true scores are estimated by regressing observed scores toward the group mean. When relatives' observed scores are also available, estimates of true scores can be improved by using the additional information. Observed scores of subjects and relatives can be used as predictors of subjects' true scores in a multiple regression. The resulting formula is presented for the case in which only one relative's score per subject is known. Estimation of true scores for the general case ofN relatives per subject is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01073115
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  • 4
    Electronic Resource
    Electronic Resource
    Sabulodes caberata guenée (Lepidoptera: Geometridae) (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 2107-2116 
    Details
    ISSN: 1573-1561
    Keywords: Sabulodes caberata Guenée ; Sabulodes aegrotata Guenée ; omnivorous looper ; Lepidoptera ; Geometridae ; sex pheromone ; (Z,Z)-6,9-nonadecadiene ; (Z)-9-nonadecenekw] ; n-nonadecane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A 6,9-nonadecadiene, (Z)-9-nonadecene, andn-nonadecane were identified in extracts of sex pheromone glands of femaleSabulodes caberata Guenée. Potential pheromonal activity of gland components was assessed by electroantennogram measurements of gas-chromatographic fractions of abdominal tip extracts. Chemical identification was based on gas chromatography and mass spectrometry of parent compounds, hydrogenation products, ozonolysis products, dimethyl disulfide adducts, and synthesis. The monoene was synthesized via coupling of alkyl and acetylenic intermediates. (Z,Z)-6,9-Nonadecadiene (Z6,Z9-19∶H) was synthesized from methyl linoleate via chain lengthening. SyntheticZ6,Z9-19∶H had the same retention times on polar and nonpolar capillary gas-chromatographic columns as the 6,9-nonadecadiene from the sex pheromone glands. In field testsZ6,Z9-19:H alone produced trap catch of maleS. caberata and addition of (Z)-9-nonadecene orn-nonadecane had no effect on trap catch.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020313
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  • 5
    Electronic Resource
    Electronic Resource
    Immobilization of enzymes in porous supports: Effects of support-enzyme solution contacting (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 892-900 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Proteins have been immobilized in porous support particles held in a fixed-bed reactor through which protein solution is continuously circulated. Changing the recirculation flow rate alters the observed immobilization kinetics and the maximum enzyme loading which can be achieved for glucose oxidase and glucoamylase on carbodiimide-treated activated carbon and for glucoamylase immobilized on CNBr-Sepharose 4B. Direct microscopic examination of FITC-labelled protein in sectioned Sepharose particles and indirect activity-loading studies with activated carbon-enzyme conjugates all indicate that immobilized enzyme is increasingly localized near the outer surface of the support particles at larger recirculation flow rates. Restricted diffusion of enzymes may be implicated in this phenomenon. These contacting effects may be significant considerations in the scaleup of processes for protein impregnation in porous supports, since apparent activity and stability of the final preparation depend on internal protein distribution.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260260812
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Intracellular equilibrium calculations based on small systems thermodynamics (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 1520-1523 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260271020
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of unstable recombinant Saccharomyces cerevisiae population growth in selective medium (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 996-1006 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Widely applied selection strategies for plasmid-containing cells in unstable recombinant populations are based upon synthesis in those cells of an essential, selection gene product. Regular partitioning of this gene product combined with asymmetric plasmid segregation produces plasmid-free cells which retain for some time the ability to grow in selective medium. This theory is elaborated here in terms of a segregated model for an unstable recombinant population which predicts population growth characteristics and composition based upon experimental data for stable strain growth kinetics, plasmid content, and selection gene product stability. Analytical solutions from this model are compared with an unsegregated phenomenological model to evaluate the effective specific growth rate of plasmid-free cells in selective medium. Model predictions have been validated using experimental growth kinetics and flow cytometry data for Saccharomyces cerevisiae D603 populations containing one of the plasmids YCpG1ARS1, YCpG1ΔR8, YCpG1ΔR88, YCpG1ΔH103, YCpG1ΔH200, pLGARS1, and pLGSD5. The recombinant strains investigated encompass a broad range of plasmid content (from one to 18 plasmids per cell) and probability α of plasmid loss at division (0.05 ≤ α ≤ 0.42). Experimental data for all strains considered is inconsistent with the hypothesis that plasmid-free cells are unable to grow in selective medium. For a given value of a, the fraction of plasmid-containing cells in the population decreases with increasing plasmid content and increases for less stable selection gene products. This conceptual framework and mathematical model will aid in strain development for greater effective stability.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260280710
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  • 8
    Electronic Resource
    Electronic Resource
    A segregated model of recombinant multicopy plasmid propagation (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 304-310 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A segregated model of multicopy plasmid propagation has been formulated which incorporates plasmid replication and partition functions, as well as the effect of plasmid presence on host growth rate. Growth of plasmid-free cells in selective medium is explicitly analyzed. The model parameters can be determined from experimentally measurable quantities. Propagation of a recombinant multicopy plasmid in the yeast Saccharomyces cerevisiae is analyzed using this model.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310405
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    A parametric study of cloned fusion protein expression in Escherichia coli (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 32 (1988), S. 725-730 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260320520
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  • 10
    Electronic Resource
    Electronic Resource
    Flow microfluorometry measurements of multicomponent cell composition during batch bacterial growth (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 22 (1980), S. 457-462 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260220216
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