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  • 1985-1989  (4)
  • 1980-1984  (2)
  • Chemistry  (2)
  • Computational Chemistry and Molecular Modeling  (2)
  • Collateral circulation  (1)
  • Fast Na+ system of the cardiac membrane  (1)
Source
Material
Years
  • 1985-1989  (4)
  • 1980-1984  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Krypton-81m single photon emission tomography and the collateral circulation in carotid occlusion: the role of the circle of Willis and leptomeningeal anastomosis (1983)
    Springer
    Journal of neurology 230 (1983), S. 7-17 
    Details
    ISSN: 1432-1459
    Keywords: Carotid artery occlusion ; Collateral circulation ; Krypton-81m ; Emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zerebrale Perfusionsbilder wurden bei Patienten mit Halsschlagaderverschluß untersucht. Dazu wurde eine Infusion mit Krypton 81m in die A. carotis comm., A. carotis int. und in die A. vertebralis vorgenommen und dann computergesteuerte Einzelphotonenemissionstomogramme angefertigt. Analysiert wurde, welchen Beitrag der Gefäßkranz an der Hirnbasis und die Anastomosen der Großhirnrinde leisten, um eine angemessene Blutversorgung des betroffenen Gebietes aufrechtzuerhalten. Man kam zu dem Schluß, daß das zerebrale Perfusionsbild in der Abschätzung von Nebenkreisläufen der Angiographie überlegen ist. Im Fall eines Halsschlagaderverschlusses ist der Gefäßkranz an der Hirnbasis von Bedeutung, einen Infarkt im Gebiet der perforierenden Arterien zu verhüten, während die Großhirnrinde vorwiegend über die Anastomosen der weichen Hirnhaut mit Blut versorgt wird, was die Hauptrolle der Anastomosen der weichen Hirnhaut beweist.
    Notes: Summary Cerebral perfusion images were investigated in patients with carotid artery occlusion, using single photon emission computed tomography with the infusion of krypton-81m into the internal, common carotid and vertebral arteries. The contribution of the circle of Willis and cerebral cortical anastomoses to the maintenance of adequate blood supply into the involved hemisphere was analysed. It was concluded that the cerebral perfusion image is superior to angiography in evaluating collateral circulation, and in the case of carotid occlusion, the circle of Willis is important in preventing infarction in the territory of the perforating arteries, while the cerebral cortex mainly receives its blood supply through the cortical leptomeningeal anastomoses, illustrating the major role of the leptomeningeal anastomosis as a collateral channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313592
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 329 (1985), S. 77-85 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac action potential ; Fast Na+ system of the cardiac membrane ; β-Adrenoceptor blocking agents ; Structure-activity relation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of atenolol (2–5 mmol/l), sotalol (1–2 mmol/l) and pamatolol (0.1–1 mmol/l), together with N-tertiary butyl phenoxypropanolamines with o-methyl (D-2T: 50–100 μmol/l) m-methyl (D-3T: 50–100 μmol/l) and p-methyl (D-4T:100–200 μmol/l) group as well as with o,p-methyl groups (D-24T) (50–100 μmol/l) on action potentials (APs) were investigated in isolated guinea-pig papillary muscles. All the drugs in these concentrations produced a concentration-dependent reduction of the maximum upstroke velocity (V max). The reduction ofV max in premature APs induced by stimuli interpolated between the basic driving rate of 0.25, 0.1 or 0.027 Hz decayed exponentially during diastolic intervals. The time constants of these decay processes τ for atenolol, pamatolol and sotalol ranged between 260–541 ms, those for D-3T and D-4T between 655–1,166 ms, and D-2T and D-24T between 1,565–1,931 ms. A drug which provided larger τ values caused the reduction ofV max in a wider range of the frequency. With respect to the aryloxypropanolamine derivatives so far studied (Sada and Ban 1980, 1981 a, b; Sada et al. 1983) fairly good correlations were found as follows: between logn-octanol/water partition coefficient (logP) and ED20 at 0.25 Hz, ED30 at 1 and 4 Hz for 11–14 compounds; between logP and resting block, between molecular weight and A o c i.e. the value extrapolated to the time of APD90 of the conditioning response relative to the predrugV max value which may represent a fraction of channels blocked per AP for 100 μmol/l of 20–22 compounds. With respect to 8 compounds with methyl substituents in the benzene ring or amine part the ortho methyl group makes a major contribution to increase the resting block and to increase log τ values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695196
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Structural analysis of protein variants by mass spectrometry: Characterization of haemoglobin providence using a grand-scale mass spectrometer (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 563-565 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A grand-scale mass spectrometer with high mass resolution and high transmission was employed for the analysis of haemoglobin variant. Two variants were isolated from a haemolysate by chromatography. Secondary ion mass spectrometry of complex peptide mixtures derived from these variants precisely determined the molecular weight of abnormal peptides. The molecular weight, 2857.4 and 2858.4, indicated the amino acid substitutions of asparagine and aspartic acid, respectively, for lysine at position 82 of β globin chain. The mutations had been reported in haemoglobin Providence.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200180809
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Field desorption mass spectra of tryptic peptides of human hemoglobin chains (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 25-30 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Field desorption mass spectra of tryptic peptides of normal human hemoglobin α-, β-, γ-, δ-chains and abnormal β-chain of hemoglobin S were studied. Almost all mass peaks of the protonated molecular ions of tryptic peptides and many doubly charged ions were observed. The molecular weights of all tryptic peptides were estimated from the mass spectra, the heaviest mass being m/z 2955, and coincided with the values obtained from the known amino acid sequences. The different chains of hemoglobin can be distinguished by their field desorption mass spectra. The mass spectrum of abnormal β-chain of hemoglobin S (sickle-cell-anemia) showed a shift of the characteristic line due to the mutation of amino acid.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200080107
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A specific inhibitor design approach by means of molecular dynamics calculation for porcine pancreatic elastase (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 8 (1987), S. 645-650 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: A 27-picosecond (ps) molecular dynamics calculation has been carried out for the 1:2 enzyme-ligand complex between porcine pancreatic elastase (PPE) and acetyl-alanine-proline-alanine (APA). A data analysis has been carried out using a total of 450 structures. During the simulation, the root-mean-square fluctuations (RMSF) increased compared with the x-ray data. Some differences of the hydrogen bond arrangement in the MD average structures are found especially for SER 195, suggesting the fluctuations of the ligand molecules. The radius of gyration decreased a little during the simulation. Although intermolecular hydrogen bonds between two substrates (APA1 and APA2) has not been found by a 1.65-Å high-resolution x-ray diffraction study, the MD calculation showed the intermolecular hydrogen bond between them to be 3.2 Å. The extended active site of PPE is so wide compared with the size of a tripeptide that such a hydrogen-bound hexapeptide can be more specific than tripeptides, which is consistent with the kinetic data previously reported.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540080509
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulation of the 1:1 enzyme-ligand complex between porcine pancreatic elastase and acetyl-alanine-proline-alanine (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 8 (1987), S. 801-809 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: A 31.5 picosecond (ps) MD calculation has been completed for the 1:1 enzyme-ligand complex between porcine pancreatic elastase (PPE) and acetyl-alanine-proline-alanine (APA). The 1:2 complex studied crystallographically at product saturation conditions precludes the study of a 1:1 complex (PPE and APA1); this objective has been achieved by computational methods described here. The acetyl group of the ligand was found to occupy two neighboring sites, one within the primary specificity site and the other out into solution. The primary change of the ligand structure is ψ1 torsion angle being 171.5°. Supported by an interactive graphic display, the dynamical fluctuations of a smaller ligand compared with the width of the active site as PPE were observed by the MD simulation, although the complex has not been detected by any spectroscopic method.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540080608
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    Paper (German National Licenses)
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