ISSN:
1432-1440
Keywords:
T-cell lymphoma
;
Osteosclerosis
;
Lymphokines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A patient with peripheral T-cell Lymphoma and aquired, systemic osteosclerosis is described. Bone histology showed a spectacular activation of osteoblasts accompanyed by massive new bone formation. Alkaline phosphatase in serum was elevated and increased to 〉2000 U/l when the lymphoma became refractory to chemotherapy. In the patient's serum an osteoblast-activating factor could be demonstrated using a rat osteogenic osteosarcoma cell line (ROS 17/2.8). The factor was absent during remission of the tumor. We conclude that osteosclerosis was a paraneoplastic syndrome in this patient due to the secretion of an osteoblast-stimulating factor by the T-cell lymphoma. This situation is similar to the secretion of osteoclast-activating factors described in B-cell lymphomas, particularly multiple myeloma. The characterization of such a factor could be of therapeutic relevance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01711269
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