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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Annals of hematology 35 (1977), S. 465-479 
    ISSN: 1432-0584
    Schlagwort(e): Soluble fibrin ; Latex agglutination ; Fibrin monomers ; Fibrinogen ; Blue Dextran ; Lösliches Fibrin ; Agglutination von Latexpartikeln ; Fibrin- Monomere ; Fibrinogen ; Blue Dextran
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Wir beschreiben eine empfindliche Methode für den schnellen Nachweis von löslichem Fibrin in menschlichem Plasma. Sie beruht auf der Agglutination von Latexpartikeln, die in einer Lösung von gereinigtem Fibrin und Blue Dextran 2000 suspendiert sind. Die photometrische Aufzeichnung des Abfalls der optischen Dichte (OD) wÄhrend der Agglutination führt zu quantitativen Resultaten. δOD ist abhÄngig vom VerhÄltnis der Fibrin-Monomere zum Fibrinogen im getesteten Plasma und nicht vom absoluten Gehalt an Fibrin-Monomeren.
    Notizen: Summary A sensitive method is described for the rapid detection of soluble fibrin in human plasma. It is based on the agglutination of Latex particles suspended in a solution of purified fibrin monomers and Blue Dextran 2000. Photometric registration of the decrease in optical density (OD) during agglutination allows the results to be quantitated. The δOD depends on the ratio of fibrin monomers to fibrinogen in the tested plasma rather than on the absolute amount of fibrin monomers present.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Psychopharmacology 96 (1988), S. 395-399 
    ISSN: 1432-2072
    Schlagwort(e): Dysthymic disorder ; Sleep ; Ritanserin ; Slow wave sleep
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ritanserin, a selective and potent serotonin-2 antagonist, is effective in the treatment of a variety of syndromes related to anxiety and depression, including dysthymic disorder. In animals and healthy volunteers, ritanserin specifically increases slow-wave sleep and the hypothesis arises that this effect on sleep may contribute to its therapeutic properties. Therefore, we studied the effects of ritanserin on sleep in a group of dysthymic patients (DSM-III). Polygraphic recording as well as subjective evaluations of the quality of sleep were performed before and at the end of a 4-week period of double-blind medication with either ritanserin (10 mg o.d. in the morning) or placebo. At baseline, patients showed at fragmented and superficial sleep, with low amounts of slow wave sleep. Ritanserin significantly increased Slow Wave Sleep and changed the frequency and distribution of some stage transitions during the night. No other sleep parameters were modified by ritanserin treatment.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European journal of pediatrics 145 (1986), S. 475-479 
    ISSN: 1432-1076
    Schlagwort(e): Visual acuity ; Stereo acuity ; Children 5–10 years old
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The development of visual acuity and stereopsis was studied in 321 boys and 340 girls aged between 5 and 10 years. Visual acuity was assessed by the E test and a modified version of the STYCAR test, stereo acuity by the Lang-Stereo test [17]. Both vision tests showed an increase in the median visual acuity between the ages of 5 and 10 years. The E test indicated an increase from 1.2 between 5 and 6 years to 1.5–1.7 between 7 and 10 years. The values obtained with the STYCAR test were 0.6–1.3 higher, depending on the test rating used. Visual acuity norms between 5 and 10 years are presented as empirical centile curves. No significant differences were observed in visual acuity between the left and right eyes, nor between the sexes. The right eye was found to be the leading eye in 54.8% of the boys and 54.5% of the girls (P〈0.001). The Lang-Stereo test was passed by 87.9%–94.3% of all children, and there were no significant differences with respect to age and sex. Children who failed the test had a significantly lower visual acuity than those who passed it. In the former group a significant interocular difference in visual acuity was present (P〈0.01).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-1076
    Schlagwort(e): Congenital adrenal hyperplasia ; Growth ; Delayed treatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The growth pattern is reported of 16 patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency in whom therapy was started after the age of 3 years. Treatment was initiated at a mean chronological age (CA) of 4.7 years (range 3.0–7.2) and at a mean bone age (BA) of 10.4 years (range 10.2–13.2). It consisted of hydrocortisone (mean dosage 26 mg/m2) or prednisone (8.7 mg/m2) in all, and of fluorohydrocortisone (0.05–0.1 mg daily) in five patients. At the last examination the mean duration of therapy was 5.2 years, the mean CA 10.0 years, and the mean BA 12.6 years. In 13 of the 16 patients a “catch-down growth” pattern was observed, which was characterised by a decrease in height (expressed, as SDS) for CA, a deceleration of bone maturation and increase of height (SDS) for BA, and an improvement in predicted height (Bayley-Pinneau).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    European journal of pediatrics 148 (1988), S. 19-23 
    ISSN: 1432-1076
    Schlagwort(e): Metatarsus adductus ; Axis ; Rotation ; Lower extremity ; Children, term and preterm
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A total of 484 premature children and a control group of 114 healthy term children underwent orthopaedic follow-up from birth to 5 years of age. At birth, metatarsus adductus was found to be more frequent in twins than in single infants (41% vs 16%; P〈0.01), but occurred with equal frequency in single preterm and term infants (16% vs 12%). By 5 years of age, metatarsus adductus had resolved in all the term but only in 81% of the preterm children (P〈0.05). In the preterm and term groups, knee axis (mean intermalleolar distance 22.0 mm vs 20.1 mm), tibial torsion (mean angle-1.2° vs +0.6°) and angle of gait (mean angle +1.5° vs +0.7°) at 5 years were statistically insignificant. Hip function at 5 years was similar in normal preterm and term children but significantly decreased in preterm children with cerebral palsy, more so with regard to abduction (56° vs 39°, P〈0.05) and extension (22° vs 8°, P〈0.01). The difference between the sexes was insignificant in both the preterm and term groups.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    European journal of pediatrics 143 (1985), S. 269-275 
    ISSN: 1432-1076
    Schlagwort(e): Behavioural and developmental disturbances ; Prepubertal boys ; Fragile X syndrome (Martin-Bell syndrome)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Developmental and behavioural aspects were studied in 13 boys aged 2.6–12.5 years from three families with the fragile X syndrome. The following observations were made. (1) Moderate to severe retardation was present in all boys; non-verbal IQs ranged between 25 and 67 (mean 46±14); IQ and age were negatively correlated (P〈0.01). (2) Language development was grossly delayed in all boys: most had severe articulation problems. (3) Imitative and symbolic play (e.g. doll play) were strikingly retarded as compared to abstract play (e.g. block design). (4) Autistic features such as no use of eye contact, stereotyped movements and echolalia were found in 9/13 boys; the same number showed aggressive behaviour. (5) General activity was reduced during the 1st year of life; most boys became very hyperactive during the second year; and short attention span and increased distractability were observed in all. (6) Motor development was mildly delayed; all boys were clumsy and moderately hypotonic. The fragile X syndrome ought to be considered in retarded boys with a dissociated developmental pattern, in particular a striking delay in language and play development, and autistic features.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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