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  • 1
    Digitale Medien
    Digitale Medien
    THE PLASMA FIBRINOGEN FRACTION WITH ELEVATED SIALIC ACID CONTENT AND ELONGATED γ CHAINS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 408 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb23238.x
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  • 2
    Digitale Medien
    Digitale Medien
    A sensitive latex agglutination method for the detection of soluble fibrin in plasma (1977)
    Springer
    Annals of hematology 35 (1977), S. 465-479 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Soluble fibrin ; Latex agglutination ; Fibrin monomers ; Fibrinogen ; Blue Dextran ; Lösliches Fibrin ; Agglutination von Latexpartikeln ; Fibrin- Monomere ; Fibrinogen ; Blue Dextran
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Wir beschreiben eine empfindliche Methode für den schnellen Nachweis von löslichem Fibrin in menschlichem Plasma. Sie beruht auf der Agglutination von Latexpartikeln, die in einer Lösung von gereinigtem Fibrin und Blue Dextran 2000 suspendiert sind. Die photometrische Aufzeichnung des Abfalls der optischen Dichte (OD) wÄhrend der Agglutination führt zu quantitativen Resultaten. δOD ist abhÄngig vom VerhÄltnis der Fibrin-Monomere zum Fibrinogen im getesteten Plasma und nicht vom absoluten Gehalt an Fibrin-Monomeren.
    Notizen: Summary A sensitive method is described for the rapid detection of soluble fibrin in human plasma. It is based on the agglutination of Latex particles suspended in a solution of purified fibrin monomers and Blue Dextran 2000. Photometric registration of the decrease in optical density (OD) during agglutination allows the results to be quantitated. The δOD depends on the ratio of fibrin monomers to fibrinogen in the tested plasma rather than on the absolute amount of fibrin monomers present.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00996693
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  • 3
    Digitale Medien
    Digitale Medien
    Fluid trapping of erythrocytes under hypoosmolar conditions (1987)
    Springer
    Annals of hematology 54 (1987), S. 239-245 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Osmolality ; Erythrocytes ; Rheology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 125I albumin was used to assess the amount of trapped fluid after microhematocrit centrifugation of erythrocytes suspended in buffers of different osmolality. Surprisingly the total amount of trapped fluid per volume unit of packed erythrocytes decreased with decreasing osmolality of the suspending buffer despite erythrocyte swelling. However, if the contribution of the individual erythrocyte to the trapped fluid was calculated, the trapped fluid per erythrocyte did not change between 311 mosm/kg and 256 mosm/kg. For osmolalities below 256 mosm/kg a significant increase of trapped fluid was obtained. It is concluded that the packing ability of erythrocytes is not impaired in suspending fluid of moderate to severe infraphysiological tonicity. The daily clinical experience that considerable degrees of plasma hypoosmolality are tolerated in vivo without hemolysis or impairment of oxygen transport by erythrocytes may be explained by the excellent ability of shape adaptation of erythrocytes to each other and to other surfaces such as vascular endothelia. The method of trapped fluid determination might be of potential value as a complementary method in the evaluation of erythrocyte rheology if the amount of trapped fluid is related to the individual erythrocyte.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00594200
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  • 4
    Digitale Medien
    Digitale Medien
    Creatine kinase and creatine kinase MB in endurance runners and in patients with myocardial infarction (1985)
    Springer
    European journal of applied physiology 54 (1985), S. 40-45 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Creatine kinase ; Kinetics ; Myocardial infarction ; Running ; Age
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Following a 100 km race creatine kinase (CK) creatine kinase MB (CKMB) activities were serially measured in well trained athletes and compared with enzyme activities in patients with acute myocardial infarction (AMI). The half-time of disappearance of CK (CKt 1/2) was 1.75±0.70 days in runners who trained within the 1st week after the race, and was 0.81±0.18 days in patients with AMI, P〈0.005. CKt 1/2 in runners was shorter (1.17±0.28 days) when no training was performed in the first postrace week. CKt 1/2 was linearly correlated with age (P〈0.01) in the runners but not in the patients. CKMBt 1/2 was 1.30 and 1.11 days in two runners and 0.56±0.10 days in patients with AMI (P〈0.05). In line with histologic and enzymatic findings in skeletal muscle of long distance runners as reported by other workers, our kinetic data provide further evidence that CK and CKMB are released from muscular compartments in runners other than those in patients with AMI.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426296
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  • 5
    Digitale Medien
    Digitale Medien
    Mechanisms of the haematological changes induced by hyperventilation (1988)
    Springer
    European journal of applied physiology 58 (1988), S. 233-238 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Lymphocytes ; Neutrophil leukocytes ; Thrombocytes ; Splenectomy ; Beta-blockade ; Propranolol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary During voluntary hyperventilation an increase in the lymphocyte and thrombocyte counts occurs, paralleled by an increase in plasma epinephrine and norepinephrine. All these changes are rapidly reversible after hyperventilation and are followed by an increase in the neutrophil granulocyte count. The pathophysiological mechanisms of these changes were investigated by comparison of the hyperventilation-induced changes of the blood picture in 11 normal, 9 splenectomized and 12 β-blocked volunteers. Splenectomy did not affect the hyperventilation-induced mobilization of lymphocytes and neutrophils but totally suppressed the change in the thrombocyte count, β-blockade by 80 mg propranolol did not suppress the hyperventilation-induced increase in neutrophils. It reduced the absolute increase of lymphocytes and thrombocytes by half, but it also increased the baseline counts of these cells. The study shows that hyperventilation mobilizes thrombocytes from the spleen but not from extralienal pools, and that lymphocytes and neutrophils are mobilized from extralienal pools. Whereas neutrophil mobilization is not suppressed by β-blockade, the reduction of hyperventilation-induced mobilization of lymphocytes and thrombocytes may be due to a reduction in the size of the mobilizable cell pools, and therefore cannot be interpreted as a sure indication that adrenergic mechanisms are involved in their hyperventilation-induced mobilization.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00417255
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  • 6
    Digitale Medien
    Digitale Medien
    Antibacterial prophylaxis with lactoferrin in neutropenic patients (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 310-313 
    Details
    ISSN: 1435-4373
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The prevention of enterogenic infection by human lactoferrin was tested in five neutropenic patients receiving chemotherapy for acute myelogenous leukemia. Lactoferrin did not significantly delay the onset of infection but reduced its duration and severity as judged from the course of fever. Compared with nine matched controls, lactoferrin-treated patients had a lower incidence of bacteremia on the whole and of gram-negative bacteremia in particular.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01963459
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  • 7
    Digitale Medien
    Digitale Medien
    Early stages of fibrinogen to fibrin conversion studied by static and dynamic light scattering (1981)
    New York : Wiley-Blackwell
    Biopolymers 20 (1981), S. 2035-2049 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The early steps of fibrin aggregation induced by low Reptilase concentrations were studied by means of static and dynamic light scattering. In order to obtain information on the size and shape of the first oligomers, the angular dependence of the scattered intensity and the mean Rayleigh line width were measured. Under physiological pH and ionic strength, oligomer formation was detectable immediately after enzymatic activation. Comparison of the calculated data for different models with experimental results shows that the early fibrin polymerization proceeds as an end-to-end aggregation of elongated and possibly flexible molecules approximately 75 nm long.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.1981.360201002
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  • 8
    Digitale Medien
    Digitale Medien
    The influence of calcium ions on fibrin polymerization (1987)
    New York : Wiley-Blackwell
    Biopolymers 26 (1987), S. 27-43 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The influence of calcium ions on the polymerization induced in fibrinogen solutions by thrombin and by Reptilase has been investigated by meansof static and dynamic light scattering in combination with measurements of the release of the fibrinopeptide A. The calcium concentration was varied in the range between 0.3 and 103 calcium ions per fibrinogen molecule. The enzyme concentration was chosen sufficiently low so that it was possible to make quantitative observations as a function of time, in particular, beforethe onset of gelation. Likewise, the influence of calcium ions on the enzymatically induced polymerization of fragment X was studied. The results indicate that there are at least three mechanisms by which calcium can influence the evolution of the polymer system on the path to gelation and clotting. Which mechanism dominates depends upon the calcium concentration.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.360260107
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  • 9
    Digitale Medien
    Digitale Medien
    Experimental tests of a geometrical abstraction of fibrin polymerization (1986)
    New York : Wiley-Blackwell
    Biopolymers 25 (1986), S. 905-929 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: By combining measurements of the enzymatic release of fibrinopeptide A (FPA) with measurements of intensity and linewidth of Rayleigh scattering from fibrin polymer solutions prior to gelation, we have systematically tested a variety of predictions that can be made on the basis of a simple geometrical abstraction of fibrin polymerization. The experimental investigations include FPA content of fibrin polymers, aggregation of fibrin with fibrinogen, enzyme kinetics, shift of the chemical equilibrium by adding Gly-Pro-Arg-Pro or fibrinogen to the polymer solution, evolution of the polymerization, and influence of fibrinopeptide B release. Among the considered geometrical abstractions there is only one that survives the experimental tests and at the same time is compatible with the electron micrographs by other authors. The main conclusions that can be drawn are (1) the location of binding sites A must be taken from the structure of the fibrinogen molecule proposed by Hoeprich and Doolittle [Biochemistry (1983) 22, 2049-2055], (2) The fibrinogen monomer is basically centrosymmetric, (3) the state of polymerization is reversible and corresponds to a chemical equilibrium, and (4) Michaelis-Menten enzyme kinetics can be applied.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.360250511
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  • 10
    Digitale Medien
    Digitale Medien
    Fibrin polymerization studied by static and dynamic light-scattering as a function of fibrinopeptide A release (1982)
    New York : Wiley-Blackwell
    Biopolymers 21 (1982), S. 2205-2223 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The polymerization of fibrin induced by the enzyme thrombin was investigated in the pregelation phase by combining measurements of the release of the fibrinopeptides A with static and dynamic light-scattering at scattering angles ranging from 5°-150°. Without making any assumptions about the polymer distribution, one is led to the following conclusions: The aggregates are rodlike; the Flory-Stockmayer model is to be preferred over the percolation model, i.e., cyclic bonds are infrequent; in the early stages the experiments indicate a functionality f = 2 (number of reactive binding sites per monomer) that increases with increasing release of fibrinopeptides A, eventually approaching the value f = 4; the number of binding sites involved in a bond is about twice the number of the released fibrinopeptides A; and in the polymers the monomer units aggregate end-to-end in the very early stage and then in a staggered overlap.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.360211109
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