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  • 1985-1989  (3)
  • 1930-1934
  • Seizure  (2)
  • Cytochrome P450  (1)
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Years
  • 1985-1989  (3)
  • 1930-1934
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Serotonin reduction in the mouse neostriatum during hyperthermia-induced convulsions studied by immunohistochemistry (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 541-546 
    Details
    ISSN: 1432-0533
    Keywords: Serotonin ; Mouse ; Neostriatum ; Seizure ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes occurring in serotonin neurons during hyperthermia-induced convulsions were examined by means of a modified immunohistochemical method. All mice (8–12 weeks of age) exposed to the temperature of 50°C had convulsions, showing a generalized tonic and/or clonic pattern. Immediately after the convulsions, the animals were perfused transcardially with a fixative. A significant reduction in serotonin immunoreactivity was observed in the neostratum (caudate-putamen complex) of the mice which had hyperthermia-induced seizures, while the serotonin immunoreactivity remained unchanged in the neocortex and paleostriatum. These results suggest that serotonin may be an important mediator in the mechanism of hyperthermia-induced convulsions or that the susceptibility of serotonin neurons to a convulsive state is greatest in the neostriatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686197
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Further confirmation of serotonin reduction in the neostriatum during hyperthermia-induced convulsions: a quantitative immunohistochemical study (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 254-257 
    Details
    ISSN: 1432-0533
    Keywords: Serotonin ; Neostriatum ; Hyperthermia ; Seizure ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes occurring in serotonin neurons during hyperthermia and hyperthermia-induced convulsions were examined by quantiative immunohistochemistry. A marked increase in serotonin immunoreactivity was observed at the rostral and intermediate levels of the neostriatum of mice kept at high temperatures with no convulsions, and a significant reduction in serotonin immunoreactivity was verified throughout the neostiatum of mice which had hyperthermia-induced seizures. These results suggest that serotonin neurons change significantly during thermal stress and seizures, and that regional analysis is essential for an understanding of the role of serotonin neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687576
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Enhancement of carbon tetrachloride-induced liver injury by glucagon and insulin treatment (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 27-33 
    Details
    ISSN: 1433-8580
    Keywords: Carbon tetrachloride ; Insulin ; Glucagon ; Cytochrome P450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats given a dose of carbon tetrachloride (CCl4) immediately received injections of glucagon and insulin every 4h. They frequently died after 4h and showed a significantly higher mortality between 8h and 28h as compared to the control rats where such deaths occurred 16h later. At 8h, the derangements of SGPT values and prothrombin time were significantly greater in the hormone-treated rats than in the control rats. In these CCl4-intoxicated rats, hepatic reduced glutathione content at 4h was significantly reduced after hormone treatment. The treatment significantly enhanced CCl4 metabolism, conversion of14CCl4 into14CO2 in vitro, by microsomes isolated from the liver, whereas it did not affect the microsomal cytochrome P450 content. These results suggest that glucagon and insulin treatment increased CCl4 hepatotoxicity in rats through activating the cytochrome P450-dependent mono-oxygenase system. This would merit consideration for the clinical application of this treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852091
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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