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Digitale Medien

Alpha-1-Mikroglobulin in Urin und Serum bei Proteinurie und Niereninsuffizienz (1985)

Weber, M. H. ; Scholz, P. ; Stibbe, W. ; [weitere]

Springer

Journal of molecular medicine 63 (1985), S. 711-717

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ISSN: 1432-1440

Schlagwort(e): Alpha-1-microglobulin ; Beta-2-microglobulin ; Proteinuria ; Renal insufficiency

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Alpha-1-microglobulin (alpha-1-m) is a low molecular weight glycoprotein (mw 25–33 KD) that is filtered through the glomeruli and reabsorbed in the proximal parts of the renal tubules where it is catabolized. Normal ranges were established for alpha-1-m (100 healthy controls) in serum (20–42 mg/l) and urine (3.5–8 mg/l). Alpha-1-m was then measured in 341 urine samples whose protein pattern had been classified as “pathologic” and “normal” according to microelectrophoresis. Increased alpha-1-m concentrations were found in 266 out of 280 pathologic urines (5% false negative) and in 3 out of 61 normal urines (4% false positive). Beta-2-microglobulin (beta-2-m), total protein or protein test strips showed a poorer correlation to the electrophoretic results. Measurement of alpha-1-m is, therefore, the most sensitive of these methods for the detection of proteinuria. In 90 patients with low molecular weight proteinuria and either with or without renal insufficiency alpha-1-m concentrations were determined in both urine and serum. While all patients had elevated urinary alpha-1-m concentrations, increased serum values were only found in renal insufficiency (Ccrea〈100 ml/min). Independently of these results, we were also able to establish that increased alpha-1-m levels are found at decreased glomerular filtration rates (Ccrea 〈70 ml/min). Pathologic alpha-1-m concentrations therefore only allow the conclusion of isolated tubular impairment when the GFR is greater than 70 ml/min. Data from 350 patients with various renal and hypertensive diseases showed that serum alpha-1-m is a more sensitive indicator of renal insufficiency, even in the so-called “creatinine blind” range (60–100 ml/min) of the GFR than either creatinine or beta-2-m.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01733115

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Digitale Medien

Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing (1987)

Bonzel, K. -E. ; Müller-Wiefel, D. E. ; Ruder, H. ; [weitere]

Springer

European journal of pediatrics 146 (1987), S. 296-300

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ISSN: 1432-1076

Schlagwort(e): Glomerulonephritis, antiglomerular basement membrane antibody-mediated ; Renal failure ; Hydrocarbons ; Sniffing ; Plasmapheresis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and deliberate sniffing of Pattex glue, a mixture of hydrocarbons which possibly may affect the structure of glomerular basement membrane. After treatment by repeated plasmapheresis and drug immunosuppression autoantibodies disappeared from serum but renal function was not influenced. Renal damage is a potential hazard for glue sniffing adolescents.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00716479

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Digitale Medien

Storage of the phytochrome-mediated phototropic stimulus of moss protonemal tip cells (1988)

Hartmann, E. ; Weber, M.

Springer

Planta 175 (1988), S. 39-49

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ISSN: 1432-2048

Schlagwort(e): Calcium (chlorotetrcycline fluorescence) ; Ceratodon ; Monensin ; Phototropism (moss) ; Phytochrome (moss) ; Protonema (moss) ; Tip growth (moss protonema)

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract A phytochrome-regulated phototropic response of the moss Ceratodon purpureus was investigated. Chlorotetracycline (CTC) was used to visualize membrane-associated calcium gradients in the tip cell of moss caulonemal filaments. A tip-to-base Ca2+ gradient was observed. The ionophore monensin rapidly inhibited the growth of the tip cell and abolished the CTC fluorescence. Six hours after transferring to inhibitor-free medium, protonemal growth resumed and reached the normal growth rate within 12 h. The growth was accompanied by a reappearance of the CTC-fluorescence gradient. Unilateral irradiation given during the monensin treatment or after the treatment during the period when growth inhibition persisted led, with the re-initiation of growth, to a typical positive phototropic bending in complete darkness. Far-red light applied just before the growth response started, or during growth inhibition, abolished the phototropic response. The phytochrome-mediated signal was qualitatively (position) and quantitatively (degree of bending) memorized. Signal perception and response could be separated temporally. This result indicates that at least under some circumstances, e.g. under the influence of monensin, the phytochrome-mediated signal can be stored for several hours in darkness. Calcium seems to be essential for the processing of polar growth only. A specific function (second messenger) in phytochrome-dependent signal transduction could not be confirmed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00402880

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Digitale Medien

Untersuchungen an oxidischen Katalysatoren. XLIV. Beeinflussung des katalytischen Verhaltens modifizierter Zeolithe vom Typ ZSM-5 durch thermische BehandlungProfessor Wolfgang Wieker zum 60. Geburtstage am 19. April 1987 gewidmet (1987)

Wendlandt, K.-P. ; Reschetilowski, W. ; Unger, B. ; [weitere]

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 547 (1987), S. 142-148

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ISSN: 0044-2313

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: Studies on Oxide Catalysts. XLIV. Modification of the Catalytic Behavior of Modified ZSM-5 Zeolites by Thermal TreatmentThe catalytic activity, the shape selectivity, and the deactivation behavior of ZSM-5 in paraffin cracking reactions can be regulated by a thermal pretreatment. A minimum of the deactivation rate as a function of zeolite pretreatment time at 600°C found in the hexane cracking could be verified in the methanol conversion reaction to gasoline.

Notizen: Die katalytische Aktivität, die Formselektivität und das Aktivität-Zeit-Verhalten des ZSM-5 beim Spalten von Paraffinen kann durch thermische Vorbehandlung stark beeinflußt werden. Ein in der Spaltung von Hexan gefundenes Minimum der Desaktivierungsgeschwindigkeit als Funktion der Dauer der Vorbehandlung bei 600°C konnte in der Methanolumwandlung zu Benzin verifiziert werden.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/zaac.19875470416

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