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  • 1985-1989  (124)
  • Chemistry  (111)
  • Computational Chemistry and Molecular Modeling  (6)
  • Nervus terminalis  (4)
  • AIDS  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Verlaufsbeobachtungen bei HIV-infizierten homosexuellen Männern mit Lymphadenopathiesyndrom (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 864-872 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Lymphadenopathy ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 26 homosexual men with antibodies to HIV and generalized lymphadenopathy were examined between 1982 and 1984. Lymphadenopathy was accompanied by clinical symptoms such as fever, diarrhoea and weight loss (50%), moderate leukopenia (15%), lymphocytosis (50%), hypoergy to intraepidermal skin test with recall-antigens (12%), elevated serum levels of IgG (62%), IgA (23%), IgM (19%), beta-2-microglobulin (76%) and neopterin (69%), diminished absolute numbers of CD4-helper cells in the peripheral blood (24%) and an inversion of the ratio CD4-helper cells/CD8-suppressor cells both in blood (64%) and in lymphnodes (36%). Mitogen induced lymphocyte proliferation was significantly lower and the serum levels of gamma-interferon were significantly higher than in healthy controls. Lymphnode biopsy revealed only nonspecific reactive hyperplasia with follicular hyperplasia in 54%, a mixed pattern of both follicular hyperplasia and follicular involution with paracortical expansion in 25% and follicular involution with paracortical expansion in 21%. 22 patients were followed longitudinally for a median time of 37 months (33–51 months). 10 patients (46%) developed fullblown AIDS within a median period of 35 months (24–46 months) after first examination and 43 months (36–77 months) after the anamnestic onset of the lymphadenopathy syndrome. The parameters distinguishing these patients from those without progression of disease were higher serum levels of gamma-interferon, higher relative and absolute numbers of CD8-suppressor cells in the peripheral blood, a reduced number of CD4-helper cells in the lymphnodes, and a lower CD4/CD8 ratio as well in the peripheral blood as in the lymphnodes. Despite of the significant differences, these parameters varied in a wide range. Therefore, we could not establish a symptom likely to predict the emergence of AIDS in an individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737007
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  • 2
    Electronic Resource
    Electronic Resource
    Manifestation von AIDS in HIV-infizierten homosexuellen Männern mit Lymphadenopathie-Syndrom (LAS) (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 936-939 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Lymphadenopathy ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 26 homosexual men with HIV-infection and lymphadenopathy syndrome were examined between 1982 and 1984 and prospectivelly observed over a period of 58 months (median, range 53–69 months). 16 (61.5%) developed full blown AIDS within a median period of 41 months (23–63 months). 12 of them died 50 months (median, range 29–67 months) after the first examination. 10 patients showed no symptoms of AIDS after a median observation time of 57 months (54–63 months). A panel of clinical symptoms, signs of concomitant infections, chemical and immunological analyses, including a lymphnode biopsy were correlated to the course of the disease. A decreased proportion of CD4-cells and a lower CD4/CD8ratio in the lymphnode suspensions at the first examination in patients with disease progression were the only parameter which correlated significantly with the development of AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721419
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  • 3
    Electronic Resource
    Electronic Resource
    Demonstration of antibodies to the surface (anti-p41) and core proteins (anti-p24) of the human immunodeficiency virus (HIV) in individuals positive for anti-HIV (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 596-599 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus ; AIDS ; Anti-HIV ; Anti-p41 ; Anti-p24
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diagnosis of infection with the human immunodeficiency virus (HIV) relies on the demonstration of antibody to this virus. Occasionally, the combined analysis of sera using ELISA and western blot reveals false-positive results. We have compared a newly developed test to detect antibodies to the core (anti-p24) and surface (anti-p41) proteins of HIV with the established tests described above. Anti-p24 and anti-p41 were negative in three individuals positive for anti-HIV by ELISA and immunoblot; they had a low risk to acquire HIV infection and were clinically and immunologically normal and suspected false positive previously. In 62 individuals at risk, anti-p41 was always positive while anti-p24 was negative in 24/62 individuals including all but one patient with AIDS. The data indicate that this new test may replace the western blot as a reliable, widely available, and standardized confirmatory assay. In addition, preliminary evidence needs to be confirmed that quantitative analysis of anti-p24 might be of prognostic value in the course of HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726665
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  • 4
    Electronic Resource
    Electronic Resource
    Tracing of single fibers of the nervus terminalis in the goldfish brain (1986)
    Springer
    Cell & tissue research 245 (1986), S. 143-158 
    Details
    ISSN: 1432-0878
    Keywords: Nervus terminalis ; Telencephalon ; Diencephalon ; Tracer (cobalt, HRP) studies ; Olfactory system ; Goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Central projections of the nervus terminalis (n.t.) in the goldfish were investigated using cobalt- and horseradish peroxidase-tracing techniques. Single n.t. fibers were identified after unilateral application of cobalt chloride-lysine to the rostral olfactory bulb. The central course and branching patterns of individual n.t. fibers were studied in serial sections. Eight types of n.t. fibers are differentiated according to pathways and projection patterns. Projection areas of the n.t. include the contralateral olfactory bulb, the ipsilateral periventricular preoptic nucleus, both retinae, the caudal zone of the periventricular hypothalamus bilaterally, and the rostral optic tectum bilaterally. N.t. fibers cross to contralateral targets in the anterior commissure, the optic chiasma, the horizontal commissure, the posterior commissure, and possibly the habenular commissure. We propose criteria that differentiate central n.t. fibers from those of the classical secondary olfactory projections. Branching patterns of eight n.t. fiber types are described. Mesencephalic projections of the n.t. and of secondary olfactory fibers are compared and discussed with regard to prior reports on the olfactory system of teleosts. Further fiber types for which the association with the n.t. could not be established with certainty were traced to the torus longitudinalis, the torus semicircularis, and to the superior reticular nucleus on the ipsilateral side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218095
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  • 5
    Electronic Resource
    Electronic Resource
    Central projections of the nervus terminalis in the bichir, Polypterus palmas (1986)
    Springer
    Cell & tissue research 244 (1986), S. 181-186 
    Details
    ISSN: 1432-0878
    Keywords: Chemoreception ; Nervus terminalis ; Telencephalon ; Tracer (HRP) studies ; Polypterus palmas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Central pathways of the nervus terminalis (n.t.) in the bichir, Polypterus palmas, were studied with the use of tracing techniques. After application of horseradish peroxidase to the unilateral olfactory mucosa labeled n.t. fibers were traced in seven distinct bundles through the subpallium. Projection areas are found in the precommissural ventral nucleus of the area ventralis telencephali ipsilaterally, the anterior commissure and commissural parts of the periventricular preoptic nucleus bilaterally; few n.t.-fibers cross via the anterior commissure to the contralateral side; no fibers were observed to turn rostrally to the contralateral olfactory bulb. Major targets of the n.t. include a restricted ventral part of the periventricular preoptic nucleus at the level of the optic chiasma bilaterally, and the periventricular nuclei located between the thalamic nuclei and the hypothalamus bilaterally. N.t. fibers continue their course through the ipsilateral hypothalamus and are traced as far as the mesencephalic tegmentum ipsilaterally. N.t. terminations are found consistently within the boundaries of periventricular cell nuclei, suggesting axosomatic synaptic contacts. We propose a differentiation of the n.t. ganglion cells into a distal (mucosal) and proximal (bulbar) type regarding the peripheral cell processes. Our findings are compared with those of other reports on the n.t. system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218396
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  • 6
    Electronic Resource
    Electronic Resource
    A light- and electron-microscopic study of mesencephalic neurons projecting to the ganglion of the nervus terminalis in the goldfish (1986)
    Springer
    Cell & tissue research 246 (1986), S. 63-70 
    Details
    ISSN: 1432-0878
    Keywords: Nervus terminalis ; Mesencephalon ; HRP/cobalt technique ; Locus coeruleus ; Teleosts ; Goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After application of various neuronal tracers (horseradish peroxidase, cobalt-chloride lysine, true blue) to the ganglion of the nervus terminalis a small number of neurons was retrogradely labeled in the mesencephalon. As revealed by combined horseradish peroxidase and catecholamine-fluorescence techniques these neurons are located in the isthmic area immediately rostral to, but not within the locus coeruleus. Cobalt-labeled axons of the mesencephalic neurons were traced individually in serial sections. Neurons projecting contralaterally cross in the horizontal commissure. Tracing of single fibers provided no evidence for axon collaterals within this pathway. Retrograde labeling reveals two different types of isthmic neurons afferent to the ganglion of the nervus terminalis: One smaller-sized type is located bilaterally and consists of four to six neurons; another type possessing many dendritic processes was consistently found as only one single cell located contralateral to the side of injection. The existence of two types of neurons was confirmed by their cytological differences: The small-sized type receives only sparse perisomatic input, while the large-sized type shows heavy somatic and dendritic, probably monoaminergic innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219000
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  • 7
    Electronic Resource
    Electronic Resource
    The nervus terminalis also exists in cyclostomes and birds (1987)
    Springer
    Cell & tissue research 250 (1987), S. 431-434 
    Details
    ISSN: 1432-0878
    Keywords: Nervus terminalis ; Chemoreception ; Olfactory mucosa ; Tracer (HRP, cobalt) studies ; Lampetra planeri ; Domestic mallard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The terminal nerve has been described in all vertebrate classes, with the exception of cyclostomes and birds. With regard to this question, we have examined representatives of these two classes using tracer techniques, and found a terminal nerve in larval lampreys and young domestic mallards. Horseradish peroxidase or cobaltous lysine was injected into the olfactory mucosa, which is known to be innervated by peripheral branches of the terminal nerve. The brains were then searched for labeled, centrally directed fibers of the terminal nerve that project further caudally than the glomerular layer of the olfactory bulb. In larval lampreys, centrally projecting fibers of the terminal nerve were found in the tel-, diand mesencephalon. Termination of labeled fibers was observed in the hypothalamus. Some fibers of the terminal nerve cross to the contralateral side via the commissure of the posterior tuberculum. In young ducks, the terminal nerve projects ipsilaterally along the medial edge of the telencephalon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219088
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  • 8
    Electronic Resource
    Electronic Resource
    Zur statistik des einbaus einer als regler in polyamid 12 verwendeten aliphatischen dicarbonsäureHerrn Prof. Dr. Dr. h. c. H. Hellmann zum 75. Geburtstag gewidmet. (1989)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 169 (1989), S. 193-209 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: As hard blocks in polyether block amides, polyamides are used whose length is intensively regulated by dicarboxylic acids. Since, with regard to melting and crystallization behaviour, this acid constitutes an interfering structural unit in the chain, and in the case of a completely converted product each chain contains one acid molecule, it is essential to know where in the chain incorporation will occur. As opposed to monofunctional chain regulators which always form a chain end, a bifunctional chain regulator can a priori also be randomly incorporated into the inner part of the chain. This leads to a far greater interference than occurs if the chain regulator molecule and the chain end, which acts as an interfering unit in any case, coincide with each other.By means of adipic acid-regulated oligoamides based on lauryl lactam, the incorporation of the chain regulator was examined by NMR spectroscopy and compared with model calculations. This resulted in a close match only if it was presupposed that the incorporation was carried out randomly with the same degree of probability at any point whatsoever between two lauryl lactam structural units or at the chain end.Further calculations illustrate the effects of the incorporation of the chain regulator on the size of the amorphous portion.
    Notes: Als Hartblöcke in Polyetherblockamiden werden durch Dicarbonsäuren stark geregelte Polyamide eingesetzt. Da die Säure in Hinblick auf das Schmelz- und Kristallisationsverhalten einen Störbaustein in der Kette darstellt und bei einem ausgeregelten Produkt jede Kette ein Säuremolekül enthält, ist es von Bedeutung zu wissen, wo in der Kette der Einbau erfolgt. Anders als bei monofunktionellen Reglern, wo der Regler stets ein Kettenende bildet, kann ein bifunktioneller Regler a priori auch statistisch im Inneren der Kette eingebaut werden. Dies führt zu einer viel stärkeren Störung, als wenn das Reglermolekül und das sowieso als Störstelle wirkende Kettenende zusammenfallen. Anhand adipinsäuregeregelter Oligoamide auf Basis von Laurinlactam wird kernresonanzspektroskopisch der Einbau des Reglers untersucht und mit Rechnungen verglichen. Es ergibt sich nur dann gute Übereinstimmung, wenn vorausgesetzt wird, daß der Einbau statistisch erfolgt und dabei mit gleicher Wahrscheinlichkeit für jede beliebige Stelle zwischen zwei Laurinlactambausteinen oder am Kettenende abläuft. Weitere Rechnungen verdeutlichen den Einfluß des Reglereinbaus auf die Größe des amorphen Anteils.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1989.051690118
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  • 9
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen. 231. Mitteilung230. Mitteilung s. [1].. Bafilomycin-A1-21-O-(α-L-rhamnopyranosid): Strukturaufklärung durch chemische Verknüpfung mit Bafilomycin A1 und Leucanicidin (1985)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 68 (1985), S. 83-94 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Isolation of Bafilomycin-A1-21-O-(α-L-rhamnopyranoside). Structural Determination by Chemical Correlation with Bafilomycin A1 and LeucanicidinFrom cultures of an actinomycete strain, the known antifungal and insecticidal antibiotic leucanicidin (1) and a hitherto unknown antifungal antibiotic, bafilomycin-A1-21-O-(α-L-rhamnopyranoside) (2), were isolated. The latter is spectroscopically closely related to 1 and bafilomycin A1 (3) and gave degradation products identical with compounds obtained by analogous degradation of 1 and 3.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19850680111
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  • 10
    Electronic Resource
    Electronic Resource
    Etudes sur les composés organométalliques. Partie XXIPartie XX: [1].. Contribution à l'étude de la décomposition du tétracyclohexyltitane (1985)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 68 (1985), S. 1698-1703 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on Organometallic Compounds. Contribution to the Study of Thermal Decomposition of TetracyclohexyltitaniumThermal decomposition of tetracyclohexyltitanium proceeds in a different manner for the solid compound and for etheral solution. We propose an explanation of the decomposition mechanisms based on radical reactivities and compare our results with previous literature data.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19850680625
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