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  • 1985-1989  (3)
  • Allograft  (1)
  • Avian myeloblastosis virus  (1)
  • Monte Carlo method  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus (1988)
    Springer
    Experimental brain research 73 (1988), S. 15-22 
    Details
    ISSN: 1432-1106
    Keywords: Neural transplantation ; Major histocompatibility complex ; Allograft ; Rejection ; T cell subset
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using an immunocytochemical method, we examined the immunological responses of adult mice to intracerebellar syngeneic and allogeneic fetal mouse brainstem transplants (embryonic days 12–14). Syngeneic grafts and major histocompatibility complex (MHC)-compatible and non-MHC-incompatible allogeneic grafts survived well, showing no histological signs of rejection even 6 months after transplantation, and with no expression of MHC antigens being observed in any of the grafts. However, most cases of both MHC- and non-MHC-incompatible allografts showed rejection responses, such as marked neovascularization, cellular infiltration and necrosis, two weeks to one month after transplantation. In animals showing rejection, Class I MHC antigens were found on grafted neuronal tissue. An increased number of reactive astrocytes was also observed in the grafts. High levels of Class I antigen expression and prominent gliosis correlated with vigorous cellular infiltration. A quantitative analysis of T cell subsets in the animals showing rejection revealed that the L3T4/Lyt-2 ratio was 1.02±0.21 (mean ± S.D.), indicating that helper/inducer and cytotoxic/suppressor T cells appeared equally in the rejection of MHC- and non-MHC-incompatible allografts. We consider that in these experiments, the brain was not completely an immunologically privileged site, and that MHC- and non-MHC-incompatible intraparenchymal neural transplants were not shielded from host immune surveillance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279656
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear design for a heavy ion-beam fusion reactor, HIBLIC (1985)
    Springer
    Journal of fusion energy 4 (1985), S. 323-338 
    Details
    ISSN: 1572-9591
    Keywords: heavy ion beam ; HIBLIC ; target ; reactor chamber ; beam port ; Monte Carlo method ; activity ; tritium breeding ; energy multiplication ; radiation damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A nuclear analysis was carried out for a heavy ion-beam fusion reactor, HIBLIC. The analysis includes the target and chamber neutronics, time-dependent radiation damage in the first wall, and radiation streaming through beam ports. It is found that the reactor chamber is characterized by its high tritium breeding ratio, low radiation damage in the second wall, and low induced activity. To reduce the radiation damage in the superconducting, focusing magnets, tapering the beam ports along the direct line-of-sight component of the source neutron is necessary in the magnet regions and also in the collimator region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01058358
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antiretroviral activity in a marine red alga: reverse transcriptase inhibition by an aqueous extract of Schizymenia pacifica (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 413-416 
    Details
    ISSN: 1432-1335
    Keywords: Antiretroviral activity ; Marine algae ; Avian myeloblastosis virus ; Reverse transcriptase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An aqueous extract from the marine red alga, Schizymenia pacifica has been tested in a cell free system for its effect on reverse transcriptase from avian retrovirus (avian myeloblastosis virus), and mammalian retrovirus (Rauscher murine leukemia virus). The extract inhibited reverse transcriptase from both these retroviruses but showed almost no effect, if any, on the activity of cellular DNA polymerase alpha and RNA polymerase II in vitro. Consequently it is unlikely to have an adverse effect on the growth of cultured cell. The inhibitory activity of the extract was stable over a relatively wide pH range (pH 1–11) and was not lost after pronase digestion. Inhibitory activity of the extract was lost after boiling at 100°C in 0.67 N HCl, and after treatment with 100 mM NaIO4. The active principle in the extract has an apparent molecular weight in excess of 100 000 daltons. This new reverse transcriptase inhibitor is probably a polysaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390034
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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