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  • 1985-1989  (2)
  • Bone alloimplants  (1)
  • Gene expression
  • Ultrastructure
  • 1
    ISSN: 1432-0568
    Keywords: Cecum ; Germ-free rat ; Microflora inoculation ; Morphometry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The structural changes of the cecal wall in germfree rats were observed at regular intervals after the inoculation of fecal microflora from conventional rats. Quantitative light microscopy showed that most of the elements in the cecal wall increased at 12 or 24 h and reached peak values at 4 days after inoculation. On the 7th day, they decreased approximately to the values for conventional rats. The crypts were bent or widely open till 24 h but were not after the 4th day. Hyperplasia of the crypt epithelial cells including mucous-type cells was observed following microbial inoculation. Electron microscopy revealed that most of the epithelial cells lining the mucosa were typical columnar cells. Desquamation of the epithelial cells and contraction of the muscle fibers were often seen on 4th day. The mucous-type cells were divided into two types, goblet and non-goblet mucous-type cells. Reduction of cecal volume after microbial inoculation may be mainly caused by muscle contraction in the early period and hyperplasia and desquamation of the epithelial cells may suggest their role as the first and non-specific defense line prior to operation of the specific immune system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 11 (1987), S. 89-94 
    ISSN: 1432-5195
    Keywords: Bone alloimplants ; Decalcified ; Osteoinduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Afin d'apprécier l'efficacité clinique des allogreffes osseuses décalcifiées en surface et totalement décalcifiées, nous avons comparé radiologiquement l'incorporation de ces deux types d'allogreffes dans le lit osseux récepteur chez des malades opérés de butée de la hanche. Nous nous sommes référés aux résultats cliniques obtenus avec des autogreffes. Dans tous les cas, les deux types d'allogreffes décalcifiées se sont bien incorporés à l'os réceptuer. Cependant, dans les cinq cas examinés, les allogreffes totalement décalcifiées se sont résorbées avec peu ou sans apposition d'os nouveau. En revanche, les allogreffes décalcifiées en surface ont été parfaitement incorporées, bien qu'il ait fallu plus d'un an pour obtenir cette incorporation. Ces constatations indiquent que, contrairement `a ce que l'on aurait pu attendre des résultats de l'expérimentation animale, la décalcification accrue des allogreffes osseuses réduit leur efficacité clinique.
    Notes: Summary The relative clinical efficacy of surface-decalcified and wholly decalcified bone alloimplants was studied by observing radiographically the incorporation of the two types into the recipient bone bed in cases of shelf arthroplasty of the hip joint. In all cases, the decalcified alloimplants were incorporated well in an intraskeletal site. However, in all five cases examined, wholly decalcified alloimplants in a paraskeletal site were resorbed with little or no new bone deposition. In contrast, surface-decalcified alloimplants in a paraskeletal site were consistently incorporated, though their complete integration required more than one year. These findings show that, contrary to the results in experimental animals, increased decalcification of bone alloimplants reduced their clinical efficacy.
    Type of Medium: Electronic Resource
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