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  • 1
    ISSN: 1432-1440
    Keywords: Calcitonin ; Carcinoembryonic antigen ; Medullary thyroid carcinoma in vitro ; Organ culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue cultures of four C-cell carcinomas (medullary thyroid carcinoma, MTC) were prepared to study the basal and stimulated calcitonin (CT) and carcinoembryonic antigen (CEA) release. Immunohistological staining of the explants for CT and CEA have been performed after various periods of culture. These MTC explants were able continuously to release CT and CEA for periods up to 157 days. The spontaneous CT and CEA release decreased sharply during the 1st week of culture, then remained nearly constant over the observation period. The CEA/CT secretion ratio slightly declined during long-term culture; CEA release seems to drop earlier than CT production. CT and CEA could be detected in the same cells by immunocytochemical technique. The septal tissue consisting of dense connective tissue and amyloid produced by tumor cells seemed to increase during long-term culture. CT, but not CEA, was stimulated by pentagastrin (10−5 M), glucagon (6×10−6 M), and dose related by calcium (2.5–20 mM) in vitro. The MTC explant organ long-term culture proved to be a useful model for studies of human CT and CEA secretion.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 590-590 
    ISSN: 1435-2451
    Keywords: C-cell (medullary) carcinoma ; Tumor recurrence ; Surgical therapy ; C-Zell-Carcinom ; Tumorrezidiv ; Chirurgische Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen 1972 und 1984 wurden 25 kurativ operierte Patienten mit C-Zell-Carcinom der Schilddrüse beobachtet. 19 Patienten entwickelten ein Tumorrezidiv. Insgesamt wurden deshalb 40 Rezidivoperationen durchgeführt. Bei fehlenden therapeutischen Alternativen und häufig inadäquater Primärtherapie ist beim Rezidiv ein erneutes chirurgisches Vorgehen erforderlich. Eine Kuration wird durch den Rezidiveingrifisehr selten beobachtet, indiziert ist aber auch eine palliative Tumor- und Metastasenexstirpation. Eine Heilung wird vor allem erreicht durch die frühe Diagnose und einen adäquaten Ersteingriff.
    Notes: Summary Between 1972 and 1984, 25 curatively treated patients with medullary carcinoma of the thyroid gland were observed: 19 of them developed tumor recurrence. Altogether, there were 40 reoperations performed. Because there are no therapeutic alternatives and primary treatment is often unsatisfactory, further surgical procedures are required. Very rarely is a cure observed by secondary operation, but palliative tumor and metastasis extirpation is also indicated. A cure is mostly obtained by early diagnosis and adequate primary operation.
    Type of Medium: Electronic Resource
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