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  • 1
    Electronic Resource
    Electronic Resource
    Anomalous atlantoaxial portions of vertebral and posterior inferior cerebellar arteries (1985)
    Springer
    Neuroradiology 27 (1985), S. 410-413 
    Details
    ISSN: 1432-1920
    Keywords: Vertebral artery ; myelography ; spinal canal ; cranial artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a review of the vertebral angiograms of 300 patients free from disease at the craniovertebral junction, we found atlantoaxial arterial anomalies in 2,3%. These were: 2 cases in which the vertebral artery ran in the spinal canal below C1, 3 cases of duplication of the vertebral artery above and below C1, and 2 cases of origin of the posterior inferior cerebellar artery at C2. Although these arteries ran in the spinal canal between C1 and C2, they never encroached upon the posterior third of the canal. From the survey of another 21 patients having bony abnormalities at the craniovertebral junction, the first type of arterial anomaly described above was seen in 4 patients and associated with failure of segmentation of the embryonic sclerotome such as occipitalization of the atlas or Klippel-Feil syndrome. It is possible to relate the development of these anomalous vessels to malarrangement of the embryonic segmental arteries. Our results indicate that one must be cautious with lateral C1/2 puncture or surgical exposure of the region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327604
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  • 2
    Electronic Resource
    Electronic Resource
    An immunohistochemical study on “neoplastic angioendotheliosis”: demonstration of B lymphocyte markers in the neoplastic cells (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 313-316 
    Details
    ISSN: 1432-0533
    Keywords: Neoplastic angioendotheliosis ; Malignant lymphoma ; B cell lymphoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frozen cerebral and renal tissue sections of an autopsied “neoplastic angioendotheliosis (NAE)” case were investigated immunohistochemically using monoclonal and heterologous antibodies to lymphocyte, monocyte, endothelial, epithelial and histiocytic antigens. In both tissues, positive stainings for surface immunoglobulin (sIg) μ and ϰ, but not λ, were observed in most of the neoplastic cells. These cells were also positive for other B cell markers (BA-1, Leu-12 and HLA-DR). No distinct staining was observed in the neoplastic cells with antibodies to T lymphocyte (OKT-11 and Leu-1) or monocyte (OKM-1) markers. Posive stainings were observed only in some small round lymphoid cells which were distributed sporadically in and around blood vessels and were considered to be reactive. No positive staining was observed in the neoplastic cells with antibodies to endothelial (factor VIII), epithelial (cytokeratin) or histocytic (lysozyme) antigens. Thus, our NAE case was shown to be of monoclonal B cell lymphoma in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690540
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  • 3
    Electronic Resource
    Electronic Resource
    Primary malignant lymphoma of the brain: demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 23-26 
    Details
    ISSN: 1432-0533
    Keywords: Malignant lymphoma ; Brain tumor ; Non-Hodgkin lymphoma ; Immunoglobulin ; Gene rearrangement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the Southern blot hybridization technique, four cases of the primary malignant lymphomas of the brain, histologically diffuse large cell lymphoma, were examined for the immunoglobulin gene rearrangements. In three lymphomas, the rearrangements were observed in both heavy and light chain genes, providing strong evidence for a B cell lineage of these tumors. On the other hand, in the remaining lymphoma, the rearrangement was observed only in the heavy chain gene. Despite this, immunohistochemical examination revealed positive stainings for heavy and light chain immunoglobulins in tumor cells, suggesting the occurrence of light chain gene rearrangement at the undetectable level. Thus, B lymphocytic differentiation at the gene level was demonstrated in three, or possibly all, of the primary intracerebral malignant lymphomas examined. Since no more than two rearrangements were detected in each immunoglobulin gene, these lymphomas were considered to be monoclonal in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308952
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  • 4
    Electronic Resource
    Electronic Resource
    An immunohistochemical analysis of T cells in primary B cell malignant lymphoma of the brain (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 27-29 
    Details
    ISSN: 1432-0533
    Keywords: Malignant lymphoma ; Non-Hodgkin lymphoma ; Brain tumor ; Tumor-infiltrating lymphocyte ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study was performed on small lymphoid cells present in frozen tissue sections of seven cases of primary B cell malignant lymphomas of the brain by using monoclonal antibodies to T cell (Leu-1, OKT-11, Leu-3a, and Leu-2a) and B cell (BA-1 and Leu-12) surface markers. In all the seven cases, positive reaction for Leu-1 and OKT-11 was seen in the majority of the small lymphoid cells which were dispersed among the lymphoma cells or clustered around blood vessles. The large neoplastic cells were unstained by these antibodies. Staining for T cell subsets with antibodies to Leu-3a and Leu-2a showed heterogeneous staining in each case. The ratio of Leu-3a+ to Leu-2a+ cells was less than one in six cases, demonstrating a suppressor/cytotoxic phenotype predominance. Most of these small lymphoid cells were negatively stained by antibodies to BA-1 and Leu-12. From these findings, it was shown that the small lymphoid cells observed in primary B cell lymphomas of the brain were of T cell lineage, distinct from the neoplastic cells, and probably reactive in nature. The implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308953
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  • 5
    Electronic Resource
    Electronic Resource
    Glomeruloid blood vessels in ethylnitrosourea-induced rat gliomas (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 240-247 
    Details
    ISSN: 1432-0533
    Keywords: Experimental glioma ; Ethylnitrosourea ; Glomeruloid blood vessels ; Endothelial proliferation ; BrdUrd immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glomeruloid blood vessels (GBVs), a characteristic histological feature of most human malignant gliomas, were recognized with high incidence in autochthonous rat gliomas induced by transplacental administration of ethylnitrosourea. To evaluate some of the biological properties of these GBVs, we carried out a study using histological methods and immunohistochemical staining for glial fibrillary acidic protein, factor VIII-related antigen (VIII Ag) and bromodeoxyuridine (BrdUrd). Of 22 animals with large, massively growing gliomas in the CNS, GBVs including conglomerate aggregations of small blood vessels with endothelial hyperplasia and strong VIII Ag expression were observed in 13 large gliomas histologically consisting of primitive neuroepithelial neoplasms (PNN; so called ependymoma) and mixed-type gliomas in combination with astrocytoma and PNN or anaplastic astrocytoma. The anaplastic gliomas in our series were devoid of GBVs. These findings indicate that GBV formation takes place in a histological variety of experimental gliomas. Furthermore, the GBVs were frequently associated with the vasculo-mesenchymal stroma in the parent gliomas, suggesting an intimate relationship with the morphogenesis of GBVs. In addition, it was shown that the GBVs had a higher BrdUrd-labelling index than that of other blood vessels in gliomas and also that of neoplastic cells in most parent gliomas, except for anaplastic gliomas. Based on these results, the possible mechanism of GBV morphogenesis is discussed with regard to the roles of macromolecules in the induction and regulation of GBVs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294657
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  • 6
    Electronic Resource
    Electronic Resource
    Primary malignant lymphoma of the brain: An immunohistochemical study of eight cases using a panel of monoclonal and heterologous antibodies (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 190-196 
    Details
    ISSN: 1432-0533
    Keywords: Malignant lymphoma ; Brain tumor ; Non-Hodgkin lymphoma ; Burkitt's lymphoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frozen sections of eight primary malignant lymphomas of the brain were examined by the immunohistochemical methods using a panel of monoclonal and heterologous antibodies to B lymphocyte (immunoglobulins, BA-1, Leu-12 and HLA-DR), T lymphocyte (OKT-11 and Leu-1) and monocyte (OKM-1) surface markers. Paraffin sections were also used in the examination of cytoplasmic immunoglobulins. Surface and/or cytoplasmic immunoglobulins (Ig) were observed in seven cases,four of which were shown to be distinctly monoclonal and the other three less so. The remaining 1 case showed no distinct staining for Ig. BA-1, Leu-12 and HLA-DR stainings were positive in four, four and five cases, respectively. The marker phenotypes of (BA-1, Leu-12, HLA-DR) were shown to be (+,+,+) in one lymphoma, (+,-,-) in three, (-,+,+,)in three, and (-,-,+) in one. Thus, it was demonstrated that the present lymphoma cases showed a marked immunological heterogeneity, and it was shown that all of them including the Ig-negative case revealed one or more of these three additional B cell markers, indicating B cell lineage of these cases. Examination of T cell and monocyte markers revealed positive staining in normal or reactive lymphoid cells distributed around blood vessels or sporadically in tumor tissues, but not in lymphoma cells. Epstein-Barr virus (EBV)-associated nuclear antigen was not demonstrated in the seven cases examined, making it unlikely that these lymphomas were related with EBV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688039
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  • 7
    Electronic Resource
    Electronic Resource
    Spectrophotometric determination of trace uranium(VI) as a mixed ligand complex with 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol and aromatic carboxylic acid (1985)
    Springer
    Journal of radioanalytical and nuclear chemistry 90 (1985), S. 247-254 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Spectrophotometric studies on a uranium(VI) ternary complex and its analytical application are described. Uranium(VI) reacts with 5-Br-PADAP to form an unstable chelate, which precipitates on standing in 48% ethanolic aqueous solution. The colour stability of uranium(VI) complex is greatly improved by the presence of aromatic carboxylic acids. For the present purpose, o-hydroxybenzoic acid and its derivatives are best suited. The calibration graph is linear up to 2.6 μg·ml−1 of uranium(VI) at 578 nm. The role of carboxylic acid as an auxiliary ligand is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060779
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  • 8
    Electronic Resource
    Electronic Resource
    Separation of rhenium by thin-layer chromatography with polyethyleneimine cellulose in hydrochloric acid media (1986)
    Springer
    Chromatographia 21 (1986), S. 708-710 
    Details
    ISSN: 1612-1112
    Keywords: Thin-layer chromatography ; Polyethyleneimine (PEI) cellulose ; Separation of 49 inorganic ions ; Re(VII) separation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The thin-layer chromatographic behavior of 49 inorganic ions on polyethyleneimine (PEI) cellulose has been investigated in hydrochloric acid media (0.01–1.0 mol dm−3). The sorption on the cellulose decreases with increasing acid concentration for most of the ions, but As(III), Ti(IV) and Te(VI) do not exhibit any Rf variation with the acid concentration. The Rf spectra of TI(I), Cd(II), Pb(II) and Zn(II) have a maximum. Ag(I), Bi(III), Nb(V), Ta(V), Mo(VI) and W(VI) are retained tightly on the layer, due to either insoluble salt formation or extensive hydrolysis. The extremely low Rf values of Hg(II), Pd(II), Au(III), Ru(III) and Pt(IV) are accounted for by stability of their chlorocomplexes. Re(VII) distributes chromatographically, having moderate Rf values between 0.3 and 0.6, so that the selective separation of Re(VII) from the other ions is feasible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02313685
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  • 9
    Electronic Resource
    Electronic Resource
    Local steroid therapy of adnexal strawberry hemangioma in infants —long-term follow-up (1986)
    Springer
    European journal of plastic surgery 9 (1986), S. 29-35 
    Details
    ISSN: 1435-0130
    Keywords: Intralesional injection of triamcinolone acetonide ; Growth delay ; Strawberry mark hemangioma ; Orbital region
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two patients with orbital or ocular adnexal neonatal hemangiomas were treated with intralesional injection of triamcinolone acetonide. Injection of steroids was started at 2 mg/kg twice a week. The doses of this drug were decreased gradually over a four week period. A dramatic reduction of the lesion was evident without a rebound phenomenon: however growth delay continued for only three months after therapy. No exact study of the storage of this compound in the tissue has been reported. The storage of triamcinolone acetonide was investigated for a period of up to 35 days in the tissue of rabbit backs. The 0 level of the residue was suggested to occur at about 60 days after injection of triamcinolone acetonide. In the two infants of the experimental study with strawberry-type nervus, the storage in the tissue of hemangioma was much higher than in rabbits. These results were comparable to the duration of the growth delay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294794
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