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  • 1
    Electronic Resource
    Electronic Resource
    Hyperthermia Potentiates the Activity of Immunotoxin Conjugates against Common Acute Lymphoblastic Leukaemia Cells in Vitro (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 511 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb36272.x
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  • 2
    Electronic Resource
    Electronic Resource
    PEG- and electroporation-induced transformation in Nicotiana tabacum: influence of genotype on transformation frequencies (1989)
    Springer
    Theoretical and applied genetics 78 (1989), S. 287-292 
    Details
    ISSN: 1432-2242
    Keywords: Direct gene transfer ; Electroporation ; Genotype influence ; Kanamycin resistance ; Nicotiana tabacum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Experimental parameters for direct gene transfer with recombinant DNA encoding neomycin phosphotransferase II (NPTII) under control of eukaryotic expression signals were established. The introduced gene was shown by the growth of transformants on media containing kanamycin, by genomic blotting and by assaying NPTII activity. Leaf protoplasts from three green genotypes of varieties xanthii and petit havanna, and from four plastome-encoded albino genotypes of Nicotiana tabacum were analyzed with respect to cell division kinetics and yield of kanamycin-tolerant colonies after direct gene transfer. No clear correlation was found between the time of onset of cell division and transformation frequency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288813
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  • 3
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 1218-1220 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727428
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  • 4
    Electronic Resource
    Electronic Resource
    The gene for the Mr 10,000 phosphoprotein associated with photosystem II is part of the psbB operon of the spinach plastid chromosome (1986)
    Springer
    Current genetics 11 (1986), S. 165-169 
    Details
    ISSN: 1432-0983
    Keywords: Photosystem II gene ; Phosphoprotein ; Plastid DNA ; Polycistronic transcription ; Spinach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We present the nucleotide and derived amino acid sequence of the gene for the 10 kd phosphoprotein associated with photosystem II. This gene was identified by comparing the recently published first nine amino acid residues for the 10 kd phosphoprotein of spinach (Farchaus and Dilley 1986) with available sequence data from the spinach plastid chromosome. The gene, designated psbH, is part of an operon that encodes the 51 kd chlorophyll a apoprotein of the photosystem II reaction center (psbB), the phosphoprotein (73 codons), cytochrome b6 (petB) and subunit IV (petD) of the cytochrome b/f complex in the order given. Northern blot analysis revealed a complex in vivo RNA pattern for this DNA segment resulting from an extensive modification of a 5.6 kb long putative primary transcript which includes a monocistronic RNA species for the phosphoprotein of approximately 420 bases. The deduced amino acid sequence for the phosphoprotein indicates a polypeptide corresponding to a molecular weight of 7.8 kb. Secondary structure predictions place all potential phosphorylation sites on the stromal side of the membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420602
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  • 5
    Electronic Resource
    Electronic Resource
    Plastocyanin is encoded by an uninterrupted nuclear gene in spinach (1986)
    Springer
    Current genetics 11 (1986), S. 171-176 
    Details
    ISSN: 1432-0983
    Keywords: Plastocyanin ; Photosynthesis ; Genomic and cDNA clones ; Sequence analysis ; Transcript ; Spinach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Plastocyanin is a member of photosynthetic electron transport chains that transfers electrons from cytochrome f to the oxidized P700 chlorophyll a pigment of the photosystem I reaction center. We have isolated and characterized cDNA- and genomic clones from spinach (Spinacia oleracea) encoding the complete plastocyanin-precursor polypeptide. The amino acid sequence derived from the nucleotide sequence shows that the precursor consists of 168 amino acid residues including a transit sequence of 69 residues. The precursor polypeptide has a predicted Mr of 16,917, the mature protein of 10,413. The available data indicate that plastocyanin derives probably from a single-copy gene. The coding region contains no intron. The size of the mRNA as determined by S1 nuclease protection experiments is approximately 660 nucleotides, although analysis of different cDNA clones suggests that longer RNA species do exist, approaching the size of the mRNA (850 bases) estimated by Northern blot techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420603
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of cDNA clones encoding the entire precursor-polypeptide for ferredoxin: NADP+ oxidoreductase from spinach (1988)
    Springer
    Current genetics 13 (1988), S. 517-522 
    Details
    ISSN: 1432-0983
    Keywords: Photosynthesis ; Ferredoxin-NADP+ oxidoreductase ; cDNA Nucleotide sequence ; Transit peptide ; Spinach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In this paper, we report the structural characterization of several spinach ferredoxin-NADP+ oxidoreductase (FNR) cDNAs ranging in size from 0.9 to 1.5 kilobases. A comparison of the deduced amino acid sequence with the known amino acid sequence determined for the spinach protein establishes that 1.4–1.5 kpb inserts span the full length of the mature protein (314 amino acid residues; Mr = 35,382). These also include an N-terminal 55 amino acid transit peptide as well as maximally 171 and 214 nucleotide 5′ and 3′ untranslated sequences, respectively. Evidence has been obtained that various forms of FNR arise from at least two similar genes. The FNR precursor (369 amino acid residues) has a calculated molecular mass of 41.2 kDa. Comparison of the transit peptide with transit peptides from two other stromal proteins shows little similarity at the level of primary sequence but some common features in secondary structure predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427758
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  • 7
    Electronic Resource
    Electronic Resource
    Nucleotide sequences of cDNA clones encoding the entire precursor polypeptide for subunit VI and of the plastome-encoded gene for subunit VII of the photosystem I reaction center from spinach (1989)
    Springer
    Current genetics 16 (1989), S. 99-108 
    Details
    ISSN: 1432-0983
    Keywords: Photosynthesis ; Photosystem I ; Subunits VI and VII ; Nucleotide sequence ; Spinach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Recombinant phage which encode the entire precursor polypeptide for subunit VI of the photosystem I reaction center have been selected from a lambda gt11 cDNA expression library made from polyadenylated RNA of spinach seedlings. The sequence predicts a precursor polypeptide of 144 amino acids (Mr = 15.3 kDa), a mature protein of 95 residues (Mr = 10.4 kDa) that lacks methionine, histidine and cysteine, and a transit peptide of 49 residues (Mr = 4.9 kDa). The corresponding gene(s) is (are) designated psaH. The gene for subunit VII, psaC, has been located in the small single-copy region of the spinach plastid chromosome using a synthetic oligonucleotide and a heterologous hybridization probe. It is part of a polycistronic transcription unit that is constitutively expressed and processed. Putative processing products include a monocistronic RNA for psaC. The polypeptide chain of 81 (deduced) amino acids is highly conserved and strikingly resembles bacterial-type ferredoxins. It harbours cysteine residues that appear to be involved in the ligation of the two 4Fe4S centres A and B in photosystem I. None of the two subunits appears to be membrane-spanning, and subunit VI, as subunit VII, is located at the reducing (stromal) side of the reaction center. All available information on the major subunits of photosystem I from spinach has been combined into a (revised) topographic model. Evidence that the innermost — plastome-encoded — core of photosystem I represents an old bacterial heritage in present day chloroplasts is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393402
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  • 8
    Electronic Resource
    Electronic Resource
    23. Präoperative Chemotherapie beim Oesophagus-Carcinom: Vorteile oder Gefahr für den chirurgischen Eingriff? (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 155-160 
    Details
    ISSN: 1435-2451
    Keywords: Esophageal carcinoma ; Operative therapy ; Preoperative (neoadjuvant) chemotherapy ; Oesophagus-carcinom ; Operative Therapie ; Preoperative Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 42 Patienten mit nicht fernmetastasiertem Plattenepithel-Carcinom des Oesophagus wurden präoperativ cytostatisch vorbehandelt (Kelsen-Schema). Bei 18 Patienten kam es zu einer partiellen, bei 2 Patienten zu einer vollständigen Tumorremission. Von 40 Patienten, die sich einem operativen Eingriff unterzogen, waren 4 inoperabel. Bei 14 Patienten konnte der Tumor palliativ und bei 22 potentiell kurativ entfernt werden. Postoperativ verstarben 4 der 36 resezierten Patienten. Eine Anastomoseninsuffizienz trat bei 5 Patienten und schwere kardio-pulmonale Komplikationen bei 4 Patienten postoperativ auf. Die Nebenwirkungen der präoperativen Behandlung waren akzeptabel und werden durch das Ergebnis der Behandlung mit einer hohen Resektabilitätsrate und einer Verbesserung der Überlebenszeit von Patienten, die auf die präoperative Chemotherapie ansprechen, gerechtfertigt.
    Notes: Summary 42 patients with localized squamous cell carcinoma of the esophagus were treated according to a phase II study with cisplatin, vindesine and bleomycin (KelsenSchema) prior to surgery. In 18 of these patients partial remission was achieved and in two cases complete remission. Of the 40 patients which were presented to surgical treatment, 4 were inoperable, in 22 cases the tumor was removed in a potentially curative manner and in 14 patients a palliative resection was performed. The postoperative mortality was 4 of 36 resected patients. Anastomotic leakage was found in 5 patients and severe cardiopulmonary complications in 4 patients. The side effects of the preoperative treatment were acceptable and seem justified by the high resectability rate and the significant improvement in survival of patients who responded to chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297807
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  • 9
    Electronic Resource
    Electronic Resource
    Lipofuscin accumulation in extraocular muscle of rats deficient in vitamins E and A (1985)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 223 (1985), S. 272-277 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influences of vitamin E and A deficiencies on the formation of lipofuscin in two different muscle fiber types of the extraocular muscle were tested. Weanling female albino rats (Sprague-Dawley) were divided into three groups and fed purified diets that were adequate or deficient in vitamin E and A: +E, +A; −E, +A; and −E, −A. After 35 weeks on this diet, the animals were killed for analysis of extraocular muscle. When examined by fluorescence microscopy, the extraocular muscle of the (−E, +A) rats showed more lipofuscin-specific fluorescence than the (+E, +A) and (−E, −A) rats. Lipofuscin was then further analyzed by electron microscopy (EM), using morphometric analysis. By this high-resolution technique, the increased lipofuscin of the (−E, +A) extraocular muscle was seen to be confined mostly to the type I fibers. The type II fibers were quite insensitive to vitamin E deficiency: in type II fibers, the (−E, +A) and (−E, −A) muscle showed very small amounts of lipofuscin, and the (+E, +A) showed none at all. Vitamin A has an influence on vitamin E-deficiency and appears to be involved in the formation of lipofuscin in type I muscle fibers of the extraocular muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02153658
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  • 10
    Electronic Resource
    Electronic Resource
    Folinic acid effect on 5-fluorouracil kinetics in vivo (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 87-90 
    Details
    ISSN: 1432-1335
    Keywords: 5-Fluorouracil ; Leucovorin ; Methotrexate ; Sarcoma 180 ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Synergy of folinic acid and FU has been shown in several experimental systems. In the present study we examined the kinetics of concurrent administration of folinic acid on the kinetics of FU in an in vivo model. Folinic acid significantly increased the amount of FU bound to the TS complex. In the sequential combination of MTX and FU folinic acid had no additional effect. The amount of FU incorporated into RNA was not affected in any of the treatment groups. The results indicate that folinic acid may improve FU cytotoxicity by increased FU binding to TS but has no additional effect on the synergistic sequential MTX-FU combination
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390490
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