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  • 1
    Electronic Resource
    Electronic Resource
    BCG induced killer cell activity (1988)
    Springer
    Urological research 16 (1988), S. 351-355 
    Details
    ISSN: 1434-0879
    Keywords: Intravesical BCG ; Peripheral blood mononuclear cells ; Killer activity against natural killer cell (NK) resistant tumors, NK type precursor and effector cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the mechanism of Bacillus de Calmette Guérin (BCG) bladder instillation therapy, the killer cell activity induced in peripheral blood mononuclear cells (PBMNCs) after BCG instillation was examined. Significant cytotoxic activity against natural killer (NK) cell resistant target tumor cells was detected after 3 days of instillation. To characterize this BCG induced cytotoxic activity further, human PBMNCs were cultured with BCG in vitro. From 24 h maximum cytotoxicity was obtained and continued for 3 days, then decreased slightly. Neither a DNA synthesis inhibitor Cytosine-arabinoside (Ara-C) nor a cytotoxic T cell (CTL) generation inhibitor Cyclosporine A inhibited this killer cell activation. Monoclonal antibody treatment revealed that both precursor and effector cells are Leu1-, 3a-, 7+, 11b+. The recognition specificity from cold target competition experiments was selective. Taken together NK type precursor was activated with BCG into NK type effector which has wider spectrum of target cells than usual NK cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256041
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  • 2
    Electronic Resource
    Electronic Resource
    Gene rearrangement in cells with natural killer activity and expression of the β -chain of the T-cell antigen receptor (1985)
    [s.l.] : Nature Publishing Group
    Nature 314 (1985), S. 631-633 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DNA from five independent NK cell lines, HY-1 (rf. 15), HY-3 (rf. 15), NKB61A2 (rf. 16), NKB61B10 (rf. 16) and B ALB/c N K (rf. 17), was examined for rearrangement of the genes coding for the 0-chain of the T-cell receptor. DNA was digested with six restriction enzymes (EcoRI, Pstl, Pvull, Hpal, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/314631a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of influences of stimulation of the Ammon's horn and subiculum to thermosensitive preoptic and septal neurons (1986)
    Springer
    Pflügers Archiv 406 (1986), S. 86-87 
    Details
    ISSN: 1432-2013
    Keywords: Thermosensitive neurons ; preoptic area ; septal area ; Ammon's horn ; subiculum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thermosensitive preoptic and septal (PO/SP) neurons were studied for their responsiveness to electrical stimulation of the dorsal Ammon's horn (DAH) and the ventral subiculum (VSB) of the hippocampal formation in the rat. DAH stimulation affected only 14 (16%) of 90 PO/SP thermosensitive neurons whereas VSB stimulation affected 77 (86%) units. The results suggests that the DAH has no major role in thermoregulation in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582959
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  • 4
    Electronic Resource
    Electronic Resource
    Responses of preoptic thermosensitive neurons to poikilothermia-inducing peptides — bombesin and neurotensin (1986)
    Springer
    Pflügers Archiv 407 (1986), S. 558-560 
    Details
    ISSN: 1432-2013
    Keywords: Bombesin ; Neurotensin ; Thermosensitive neuron ; Poikilothermia ; Preoptic area and anterior hypothalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Microelectrophoretic application of bombesin (BS) and neurotensin (NT) to thermosensitive and non-thermosensitive neurons in the preoptic and anterior hypothalamus (PO/AH) of anesthetized rats depressed the activity of 78 (54.2 %) of 144 neurons and that of 66 (51.6 %) of 128 neurons, respectively. The depressing effects of both peptides which were uniformly observed across warm-sensitive and cold-sensitive neurons in the PO/AH are consistent with their poikilothermic actions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00657516
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  • 5
    Electronic Resource
    Electronic Resource
    Osmosensitivity of preoptic thermosensitive neurons in hypothalamic slices in vitro (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 112-117 
    Details
    ISSN: 1432-2013
    Keywords: Osmosensitive neuron ; Thermosensitive neuron ; Medial preoptic area ; Hypothalamic slice ; Dehydration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of local osmotic changes on the activity of preoptic thermosensitive neurons were investigated in rat hypothalamic slices in vitro. Thirty-seven (53%) of 70 neurons recorded from the medial preoptic nucleus (MPO) (66% of thermosensitive neurons and 12% of thermally insensitive neurons) changed their firing rates in response to alterations in local osmolality of less than 15 mOsm/kg. The minimum change in osmolality to produce the neuronal response for six neurons tested was found to be less than 5 mOsm/kg. Statistical analysis revealed that there was a higher incidence of warm-sensitive neurons inhibited by hyperosmolality (50% of warm-units) and of thermally insensitive neurons which were osmotically insensitive (88%). None of the four warm-sensitive neurons tested lost either their osmosensitivity or thermosensitivity during synaptic blockade, and were taken to possess an inherent sensitivity to both temperature and osmolality. The phenomenon of reduced evaporative heat loss in dehydrated mammals may be explained, at least in part, by the reduced activity of MPO warm-sensitive neurons in a hyperosmotic environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584531
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanism of gas transport in plasma treated glassy polymer films (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 38 (1989), S. 687-705 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The effect of oxygen- and Ar-plasma treatment on glassy polysulfone and polyimide films upon the gas diffusion process was investigated in the permeation of CO2 and H2. The plasma treatment apparently induced a reduction of only the diffusivity of Henry's law population, while the diffusion coefficient of the Langmuir population was not altered by plasma treatment. The oxygen- and Ar-plasma treatment on polysulfone films is favorable for permselectivity of H2 relative to CO2. Such a surface modification of polyimide films appears to be ineffective for improvement of permselectivity of H2.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070380408
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