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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 700-700 
    ISSN: 1435-2451
    Keywords: Transplantation ; Aortic allograft ; Endothelial cells ; Histoincompatibility ; Transplantation ; Allogene Aortenklappe ; Endothelzellen ; Histoinkompatibilitat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch die gegenwärtige Operationstechnik bei Transplantation allogener Aortenklappen in subkoronare Position (n=35) wird die normale Anatomie and Hamodynamik der Aortenwurzel und der Taschenklappen gewährleistet. Die allogene Aortenklappe ist nicht thrombogen. Die postoperative Anticoagulantientherapie ist daher nicht notwendig. Bei 25 invasiv Nachuntersuchten bestand praktisch kein Druckgradient fiber dem Transplantat noch ein Reflux in die linke Kammer. Wie bei Versuchen mit Ratteninzuchtstämmen könnte bei den allogenen Transplantaten in Abhän-gigkeit der immunogenetischen Histoinkompatibilität der Endothelerhaltungsgrad abnehmen während die Degeneration des Transplantates zunimmt.
    Notes: Summary The present technique of transplantation of the aortic valve allograft in the subcoronary position (n = 35) provides normal anatomy and hemodynamics of the aortic root and valves. The aortic valve allograft is not thrombogenic and therefore requires no postoperative anticoagulant therapy. Postoperative invasive studies in 25 patients indicate that there was practically no gradient across the valve or regurgitation into the left ventricle. Animal experiments with inbred rat strains have demonstrated that the degree of maintenance of endothelial cells and increased degeneration are dependent on immunogenetic histoincompatibility.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1803
    Keywords: progressive pressure loading ; afterload ; right ventricle ; transposition of the great arteries ; right ventricular hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to determine the speed and duration of progressive pressure loading of the right ventricle to systemic pressure levels, which allows right ventricular adaptation without myocardial impairment at rest. In 8 pigs with an average weight of 22 kg progressive right ventricular pressure loading of different speeds and durations was induced with a newly developed constrictor. Pressures in the right atrium, right ventricle, and pulmonary artery as well as angiocardiographic volume parameters of the right ventricle were determined weekly over a period of 4 to 7 weeks. A fast progressive right ventricular pressure increase of 3.4 mm Hg/day during 3 weeks was associated with a 20–30% reduction of ejection fraction and a 100% increase of the end-systolic volume. Increase of end-diastolic pressure was 3 to 5 fold. A slow progressive pressure increase of 1.5 to 2.2 mm Hg/day to 100 mm Hg within 4 to 5 weeks was associated with an increase of the end-diastolic pressure to a level observed in systemic ventricles, while change of ejection fraction and end-systolic volume was minimal. The faster the increase of right ventricular pressure the flatter was the peak systolic pressure/end-systolic volume relationship. It is concluded that in contrast to sudden and fast progressive increase of afterload slow progressive increase of afterload to systemic levels does not impair right ventricular myocardial function.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-1803
    Keywords: progressive banding of arteries ; progressive pressure loading ; afterload ; ameroid ; transposition of the great arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this work was to develop a device which allows slow progressive banding of a great artery in infants within 4 to 5 weeks. Employed was the hygroscopic casein ameroid. When brought in contact with fluids, an ameroid cylinder expands characteristically. An early phase of fast expansion proceeds gradually to a phase of slow growth. Size, shape, and encasement of ameroid as well as temperature and type of surrounding fluid modify but do not alter the typical pattern of expansion. The developed constrictor (weight: 5.8 kg, length: 18 mm, diameter: 12 mm) includes a stainless steel socket containing an ameroid cylinder (length: 8.5 mm, diameter: 8 mm). The expanding ameroid pushes a piston with a concave extension (makrolon) a maximum of 2 mm against the artery, which is fixed to the metal housing by a teflon band (width: 4 mm, thickness: 0.5 mm). The band runs in 2 fitting grooves on the metal housing to which it is fixed by a metal ring with a precisely manufactured internal thread allowing exact tightening and loosening of the band around the artery. Utilization of inert materials like teflon, makrolon, and stainless steel warrents experimental and possibly clinical application of the developed small constrictor.
    Type of Medium: Electronic Resource
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