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  • 1
    Digitale Medien
    Digitale Medien
    Evolution of RNA Viruses (1988)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 42 (1988), S. 657-683 
    Details
    ISSN: 0066-4227
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.mi.42.100188.003301
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  • 2
    Digitale Medien
    Digitale Medien
    A calmodulin-binding peptide relaxes skinned muscle from guinea-pig taenia coli (1989)
    Springer
    Pflügers Archiv 414 (1989), S. 282-285 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Calmodulin ; Myosin light chain kinase ; Calmodulin antagonist ; Smooth muscle skinned fibres
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract During smooth muscle activation the calcium calmodulin complex interacts with myosin light chain kinase (MLCK) whereby activating it. A synthetic peptide analogue (RS20) corresponding to the calmodulin recognition sequence of MLCK has been synthesized and previously found to inhibit the calmodulin stimulated light chain kinase activity. Here we studied the effect of this peptide on skinned fibers from guinea pig taenia coli. Maximal contractions induced by 30 μM Ca2+ at 0.1 μM calmodulin could be completely relaxed by the peptide at 1 μM. The inhibitory effect was accompanied by partial dephosphorylation only of the regulatory myosin light chain. Relaxation could be reversed by addition of calmodulin which also increased the extent of light chain phosphorylation.The calmodulin concentration required for reversing the inhibition depended on the concentration of the inhibitory peptide suggesting that the peptide competed with MLCK for the calmodulin binding site. As the calcium-calmodulin-peptide mixture constitutes a calmodulin buffer, our results suggest, that the peptide is a calmodulin antagonist unique in terms of its potency and that less than nanomolar concentrations of free calmodulin may be required for inducing smooth muscle contractions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00584627
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  • 3
    Digitale Medien
    Digitale Medien
    Human stratum corneum polar lipids and desquamation (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 284-287 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Desquamation ; Epidermal lipids ; Ceramides ; Cholesteryl sulfate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ceramides and steryl-sulfate components from desquamated and cohesive human stratum corneum were examined using a combination of chemical and chromatographic means. Six structurally distinct series of ceramides were identified, and the relative amounts of these species, as measured by quantitative thin-layer chromatography, did not differ in cohesive and desquamated stratum corneum. In contrast, the level of cholesteryl sulfate was significantly reduced in the desquamated material. The results are in accord with the hypothesis that cholesteryl sulfate serves in cell-to-cell cohesion within the stratum corneum, and its hydrolysis may be necessary to permit shedding of cells from the surface.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00509081
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 152-154 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Arotinoids ; Sebum production ; Acne
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]-naphtalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1,2,3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00456845
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  • 5
    Digitale Medien
    Digitale Medien
    Evaluation of a method for measuring the sustainable rate of sebaceous wax ester secretion (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 266-269 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Sebum secretion ; Bentonite method ; Thin-layer chromatography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sebaceous was ester secretion rates were measured in six subjects on six occasions each, using absorption into bentonite clay and analysis of the collected lipid by quantitative thin-layer chromatography. On each occasion eight samples were collected, four from the left and four from the right side of the forehead in four successive intervals. The first two intervals, which totaled 14 h, were intended to deplete the follicular reservoir of sebum so that a constant rate of absorption could be obtained during the third and fourth intervals, which were 3 h each. Thin-layer analysis of each sample was done in triplicate. The data were examined using analysis of variance techniques to determine the reproducibility of the measurement method and to identify possible sources of variability. The intraclass correlation coefficient (r 1) for all 432 post-depletion determinations was 0.80. The reproducibility was considerably better for three of the subjects (r 1=0.93) than for the other three (r 1=0.75). Variability within the latter three subjects did not seem to be attributable to lack of reproducibility in the thinlayer analysis. Real biological variability also seems unlikely considering the holocrine mechanisms of sebum secretion. Therefore, the variability probably arises from non-representative collection of sebum into the bentonite absorbent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00417326
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 481-485 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Cyproterone acetate ; Ethinyl estradiol ; Sebum secretion ; Sebum composition ; Linoleic acid ; Acne
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of high-dose cyproterone acetateethinyl estradiol treatment on rates of sebum secretion and on the proportions of linoleic acid (18∶2Δ9,12) and sebaleic acid (18∶2Δ5,8) in the skin surface lipids of three female acne patients was examined. Changes in rates of sebum secretion were evaluated indirectly by measuring the ratio of wax esters/(cholesterol +cholesterol esters) in the subjects' skin surface lipid. In two of the subjects, this ratio indicated a reduction of sebum secretion rates to the childhood range. Concomitantly, there was an increase in linoleic acid and a decrease in sebaleic acid in all lipid classes. In the third subject, in whom there was only a small reduction in sebum secretion rate, the proportion of linoleic acid in the cholesterol esters more than doubled, but the changes in the other lipid classes were small or nonexistent. The results indicate that the proportions of linoleic acid and sebaleic acid in sebum are influenced by sebum secretion rates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455168
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