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  • 1
    Electronic Resource
    Electronic Resource
    Palliative and adjunctive measures in rectal cancer (1982)
    Springer
    World journal of surgery 6 (1982), S. 569-577 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cet article nous permet de relater notre expérience et celle de multiples auteurs en ce qui concerne les différentes méthodes thérapeutiques appliquées pour traiter le cancer du rectum: exérèse palliative, fulguration, cryo-chiruvgie, agents chimiques, encore qu'aucune étude comparative n'ait été entreprise pour apprécier leurs mérites respectifs. Dans notre série de 75 malades soumis à l'exérèse nous devons déploré une mortalité de 9,3%. Dans 88% des cas les symptomes présentés par le malade furent contrôlés cependant que la qualité de la vie fut satisfaisante jusqu'à leur décès. Le taux de la mortalité de la fulguration ne dépasse pas 0,5% mais les symptomes ne sont maitrisés que dans 40 à 80% des cas. Chez 219 malades soumis par nous mêmes à la cryo-chirurgie la mortalité fut de 2,3% cependant que le taux de la rémission atteignit 85%. La chimiothérapie a donné lieu à plusieurs études. D'après leurs données il semble que le cancer du rectum réponde mal aux différentes drogues cyto-toxiques qui ont été employées, le taux des rémissions s'étageant de 4 à 31% des cas traités.
    Notes: Abstract In this review we report our experience and that of others with palliative resection, fulguration, cryosurgery, and chemotherapy in rectal cancer. Since a trial has never been conducted to compare these procedures, it is not possible to give clear recommendations. In our study of palliative resection in 75 patients, we found an operative mortality of 9.3%. Tumor-related symptoms were controlled in 88%; the quality of life was good until death in most patients. Fulguration is reported to have a mortality rate of 0–5%, with control of symptoms in 40–80%, depending on tumor size. Cryosurgery was used in our series of 219 patients. Control of symptoms was achieved in 85% and the mortality rate was 2.3%. Side effects included unpleasant secretions for many weeks, bleeding, and stenoses. Chemotherapy has been tested in several studies. Colorectal cancer does not appear to be very sensitive to cytotoxic drugs, although numerous new substances have been tested over the past few years. Remissions have been achieved in 4–31% of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01657871
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  • 2
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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  • 3
    Electronic Resource
    Electronic Resource
    Noninvasive methods for the early detection of doxorubicin-induced cardiomyopathy (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 136-142 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin cardiomyopathy ; Systolic time intervals ; Radionuclide angiography ; Therapeutic risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-eight female patients (mean age 54 years) who underwent doxorubicin therapy because of metastatic breast cancer were submitted to radionuclide angiography at rest. Left ventricular ejection fractions (LVEFs) were found to decrease significantly with the increasing cumulative doxorubicin dosage. Patients with prior local radiotherapy showed lower LVEFs at the same dosage level than nonirradiated patients, but the difference was not statistically significant. In a further study, 52 patients (mean age 56 years) were followed up regularly for their history and systolic time intervals prior to each doxorubicin treatment course. Before starting treatment, LVEF values were normal in all cases. Fifteen of these patients complained of dyspnea at some time during the treatment period before the critical cumulative dosage level of 550 mg/m2 was reached. Nine of these 15 patients showed an increase of the PEPI:LVETI ratio (≧0.40) and 12 patients a decrease of the LVEF values at rest at the same time. The rest of the patients did not complain of cardiac symptoms and did not show any significant alterations in systolic-time-interval measurements until the borderline dosage level (550 mg/m2) was attained. To evaluate myocardial function with greater accuracy, these 15 patients were submitted to right-heart catheterization and radionuclide angiography at rest and during exercise. As a result, doxorubiciri treatment had to be discontinued in three of these patients because of heart failure of stage III or IV and treatment with methyl digoxin and nifedipine was started. In these three patients cardiotonic medication could produce more or less complete cardiac recompensation. We conclude from our findings that signs of stage-III heart failure in radionuclide angiography performed while the patient is at rest and exercising should be regarded as the upper limit of the therapeutic risk, where further doxorubicin treatment is contraindicated. Cardiotonic medication during cytostatic courses should be avoided, however, because the true functional condition of the myocardium could be masked during a potentially cardiotoxic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395392
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  • 4
    Electronic Resource
    Electronic Resource
    Pyruvatkinase-Mangel der Erythrocyten bei hereditärer Myopathie (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 156-158 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersuchungen des Erythrocytenstoffwechsels eines Falles von progressiver Muskeldystrophie ergaben eine Erniedrigung der Pyruvatkinase-Aktivität um 50%. Gleichzeitig wurde in der Skeletmuskulatur eine deutliche Verminderung der Magnesium-ATPase gefunden. — Die Bestimmung des Phosphattransfers in den roten Blutzellen zeigte eine gesteigerte32P-Abgabe, doch scheint dies nicht als Störung der Membranpermeabilität der Erythrocyten erklärt werden zu können.
    Notes: Summary Pyruvate kinase activity was found to be 50% lowered in RBC in a case with progressive muscular dystrophy. Concomitantly, the skeletal muscle showed a considerable decrease in Mg++-ATPase activity. Measurements of phosphate transfer in the erythrocytes showed a twofold increase in32P-efflux in the patient as compared to normal RBC, but this seems not to be a consequence of pathological erythrocyte membrane permeability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496810
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  • 5
    Electronic Resource
    Electronic Resource
    Reverse Transcriptaseaktivitäten im Plasma einer Patientin mit Mammacarcinom (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1076-1078 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Reverse transcriptase ; RNA-dependent DNA polymerase ; Mammacarcinom ; Reverse Transcriptase ; RNA-abhängige DNA-Polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Plasma einer Patientin mit Mammacarcinom konnte ein Enzym nachgewiesen werden, welches RNA als Template für die DNA-Synthese heranziehen kann. Dieses Enzym steht in Analogie zur reversen Transcriptase onkogener RNA-Viren und dem aus der Muttermilch isolierten Enzym von Spiegelmanet al. Die mögliche diagnostische Anwendbarkeit dieses Befundes wird diskutiert.
    Notes: Summary In the plasma of a patient with breast cancer, an enzyme was shown that might use natural RNAs as templates for the DNA synthesis. This enzyme is paralleled to the reverse transcriptase of oncogenic RNA viruses and the enzyme of Spiegelmanet al. from particles of human milk. The possible diagnostic implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468324
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  • 6
    Electronic Resource
    Electronic Resource
    Steigerung der Aufnahme Aminoacylierter Transferribonucleinsäuren menschlicher Leukocyten nach Genaktivierung durch Phytohæmagglutinin und bei Leukämie (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 138-142 
    Details
    ISSN: 1432-1440
    Keywords: Gene activation ; leukemia ; phytohaemagglutinin ; transfer ribonucleic acids ; cell permeation ; Genaktivierung ; Leukämie ; Phytohaemagglutinin ; Transfernucleinsäuren ; Zellpermeation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die in dieser Arbeit vorgelegten Ergebnisse liefern Hinweise, die für den Transport von Transfernucleinsäuren durch die Zellmembran in das Zellinnere und für das Vorliegen dieser Verbindungen in undegradierter Form intracellulär sprechen. Diese Aufnahme ist offensichtlich vom Reife- und Differenzierungsgrad von Leukocyten abhängig, da leukämische Zellen oder Blasten höhere Inkorporationsraten aufwiesen, als reife Zellen. Die Ergebnisse werden im Zusammenhang mit der Möglichkeit diskutiert, informationstragende Makromoleküle in funktionell intakte Zellen einzubringen.
    Notes: Summary The results presented in this paper provide evidence in favour of the partially undegraded transport of transfer ribonucleic acids through cell membranes of human leukocytes and of the intracellular integrity of these compounds. The magnitude of the uptake seems to depend on the grade of differentiation of blood cells; in as much as blast cells and leukemic cells appear to take up greater quantities. These results are discussed with respect to the possibility of introducing intact genetic material into living cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620752
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  • 7
    Electronic Resource
    Electronic Resource
    Über den Adeninnukleotidgehalt (ATP, ADP, AMP) normaler menschlicher Skeletmuskulatur (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 499-500 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Berichtet wird über Adeninnukleotiduntersuchungen (ATP, ADP, AMP) in normaler menschlicher Skeletmuskulatur (M. quadr. fem.). Biopsietechnik, Gewebeaufarbeitung und biochemische Bestimmungsmethode werden beschrieben.
    Notes: Summary The results of quantitations of ATP, ADP, and AMP in normal human skeletal muscle (M. quadratus femoris) are presented. The techniques of muscle biopsy, tissue preparation and the biochemical methods are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485303
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  • 8
    Electronic Resource
    Electronic Resource
    De novo Synthese von Adeninnucleotiden in Lymphocyten: Induktion durch Phytohämagglutinin (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 871-874 
    Details
    ISSN: 1432-1440
    Keywords: Lymphocytes ; Phytohemagglutinin ; de novo synthesis of Purines ; Adenine Nucleotides ; Lymphocyten ; Phytohämagglutinin ; Purinde novo Synthese ; Adeninnucleotide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Weder in menschlichen noch in Schweine-Lymphocyten ist nachin vitro Inkorporation mit 1-C14-Glycin eine Markierung freier Adeninnucleotide nachzuweisen. Dies läßt den Schluß zu, daß Lymphocyten des zirkulierenden Blutes unter den angegebenen experimentellen Bedingungen nicht oder nur in unzureichendem Maße befähigt sind, Purinnucleotidede novo zu synthetisieren. Werden die Lymphocyten dagegen mit PHA stimuliert, so kommt es zur Induktion derde novo Synthese von Adeninnucleotiden. Kinetische Studien dieses Prozesses lassen erkennen, daß während der ersten 2 Std nach Zugabe des PHA zur Lymphocytenkultur noch kein, in den folgenden Stunden jedoch ein rascher Anstieg der Synthesevorgänge eintritt.
    Notes: Summary In studying the incorporation of the purine precursor glycine-1-C14 into the adenine nucleotides of human and pig lymphocytesin vitro no labelling of adenine nucleotides could be found. It is therefore concluded that mature circulating lymphocytes do not synthesize purinesde novo. However, by stimulating the lymphocytes with PHA, induction of thede novo synthesis of purine bases could be observed. Kinetic studies of this process show thatde novo synthesis is not detectable within the first 2 hours after the addition of PHA to the lymphocyte culture, but that it increases rapidly in the following hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488944
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  • 9
    Electronic Resource
    Electronic Resource
    Beeinflussung der Nucleinsäuresynthese menschlicher Leukocyten durch ein- und doppelsträngige Polynucleotide (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 862-865 
    Details
    ISSN: 1432-1440
    Keywords: Nucleic acids ; Poly A ; Poly U ; Poly I. C. ; Ribonucleinsäuren ; Poly A ; Poly U ; Poly I. C.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Studien der Adenininkorporation in die Ribonucleinsäuren menschlicher Leukocyten nach Zusatz einsträngiger (Polyuridylsäure, Polyadenylsäure) und doppelsträngiger Polynucleotide (Polyinosin, Polycytidylsäure) ergaben eine unterschiedliche Stoffwechselbeeinflussung nach in vitro-Zusatz. Einsträngige Homoribopolynucleotide bewirkten in unserer Versuchsanordnung eine Aktivierung der Nucleinsäureproduktion, namentlich der Transfernucleinsäureanteile. Doppelsträngige Ribonucleotide verursachten dagegen eine Hemmung der Neusynthese von Nucleinsäuren, wobei Transfernucleinsäuren und ribosomale Vorstufen RNA (18 S Anteil) in geringerem Maße produziert wurden. Die Ursachen dieser Veränderungen werden diskutiert.
    Notes: Summary Adenin-C-14 incorporation in the ribonucleic acids of cultured human leukocytes was influenced by single-and double stranded synthetic ribohomopolymers in different ways. The single stranded polymers polyadenylic- and polyuridylic acid revealed slightly increased incorporation rates. The double stranded nucleotide polyinosinic-polycytidylic acid evoked reduced activities of the purified ribonucleic acids. Fractionation on a linear sucrose gradient showed a disproportional decrease of the transfer and 18 S component. The rate of nucleic acid synthesis was significantly lower with polyinosinic-polycytidylic acid-treated leukocytes. The results are discussed with respect to a prospective trial for the chemotherapy of leukaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488942
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  • 10
    Electronic Resource
    Electronic Resource
    Über das Vorkommen einer RNA-abhängigen DNA-Polymerase in menschlicher Placenta (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 41-42 
    Details
    ISSN: 1432-1440
    Keywords: RNA-dependent DNA polymerase ; RNA-abhängige DNA-Polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch chromatographische Anreicherung auf DEAE- und Phosphocellulose glauben wir Hinweise dafür gefunden zu haben, daß RNA-abhängige DNA-Polymeraseaktivitäten auch in menschlicher Placenta vorkommen könnten.
    Notes: Summary The occurrence of RNA-dependent DNA-polymerase activities in human placenta were demonstrated by a two-step enrichement procedure of the DNA-polymerases by chromatographic separation on DEAE-cellulose and phosphocellulose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484143
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