Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effects of exogenous and endogenous histamine on the respiratory system (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 991-996 
    Details
    ISSN: 1432-1440
    Keywords: Histamine ; Obstructive air way disease (OAD) ; Oversensitive bronchial system ; Histamine receptors ; Histamin ; Bronchokonstriktion ; überempfindliches Bronchialsystem ; Histamin-Rezeptoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es besteht eine statistisch strenge Korrelation zwischen dem Anstieg der Histaminkonzentration im arteriellen Plasma und dem Anstieg der Strömungswiderstände in den Atemwegen bei experimentell verursachter allergischer Atemwegsobstruktion. Das Histamin wird an sensorischen Rezeptoren im Sinne einer Reflexbronchokonstriktion wirksam. Histamin verursacht in geringen Konzentrationen im Bronchialsystem eine unspezifische Empfindlichkeitssteigerung. Diese kann auch durch Allergene in sehr geringer Konzentration hervorgerufen werden. Patienten mit chronisch obstruktiver Bronchitis haben hohe Histamin-Konzentrationen im Sputum. Durch Waschungen der inneren Oberfläche des Bronchialbaums lassen sich hohe Histamin-Konzentrationen in der Spülflüssigkeit nachweisen. Die Gabe gleicher Histamin-Konzentrationen intravenös verursacht Bronchokonstriktion. Es ist anzunehmen, daß Histamin-Rezeptoren nahe der Oberfläche der Bronchialschleimhaut vorhanden sind. Ebenso müssen in der Oberfläche oder auf der Oberfläche der Bronchialschleimhaut Mastzellen vorhanden sein.
    Notes: Summary There is a statistically strong correlation between the increase of the histamine concentration in the arterial plasma and the increase of airway resistance. The histamine causes a reflex bronchoconstriction on the sensory receptors. Histamine in low concentration increases the unspecific reaction in the bronchial system. This can also be achieved using low concentrations of allergen aerosols. Patients with chronic obstructive bronchitis show high concentrations of histamine in the sputum. The bronchoconstrictive potency of this histamine was found to be not always active. Higher concentrations of histamine can be liberated by washing the inner surface of the bronchial tree. Histamine injected in similar concentrations as that measured in the sputum causes bronchoconstriction. There should be high concentrations of histamine receptors as well as mast cells near the surface of the mucosa of the bronchial wall. There are many questions remaining open, which will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716960
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Local release of histamine, prostaglandin F2α and thromboxane B2 into the tracheal lumen and its influence on airways reactivity (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 315-322 
    Details
    ISSN: 1432-1440
    Keywords: Histamine ; Prostaglandin F2α ; Thromboxane B2 ; Mediator release ; Airways reactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of tracheal lavage with ascaris extract (AE) on airway response to acetylcholine (ACH) and histamine (Hi) was investigated in a series of 24 dogs. AE administered to a restricted area of the trachea resulted in a release of various mediators such as Hi, prostaglandin F2α (PGF2α, measured as the metabolite 15-keto-13, 14-dihydro-PGF2α) and thromboxane B2 (TXB2) into the tracheal lumen. This differed from H2O administration which resulted in no increased release of these mediators. The relatively small concentrations of these substances measured in arterial plasma argue for the role of these mediators on a local basis. On the other hand, tracheal lavage with allergen induced changes in airway response to ACH and Hi aerosols which was not observed after tracheal lavage with water. An interaction between this allergen-induced mediator release into the trachea and peripheral airways reactivity could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716448
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Wirkung von Acetylcholin- und Histamininhalationen sowie Hypoxie auf die arterielle Plasma-Histaminkonzentration (Versuche an Hunden) (1980)
    Springer
    Research in experimental medicine 177 (1980), S. 181-191 
    Details
    ISSN: 1433-8580
    Keywords: Plasma histamine concentration ; Airway obstruction ; Acetylcholine inhalation ; Histamine inhalation ; Hypoxemia ; Plasma-Histaminkonzentration ; Atemwegsobstruktion ; Acetylcholininhalation ; Histamininhalation ; Hypoxämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Inhalation von Histamin wie Acetylcholin bewirkt Histaminfreisetzung mit Anstieg der arteriellen Plasma-Histaminkonzentration. Die hierbei erreichten Plasma-Histaminkonzentrationen sind im Verhältnis zum Anstieg von Edyn wesentlich geringer als bei einer allergenbedingten Histaminfreisetzung. Die entsprechenden Edyn-Anstiege nach Acetylcholin wie nach Histamin können nur zu einem geringen Teil auf das freigesetzte Histamin bezogen werden. Die dem Anstieg von Edyn entsprechenden Anstiege der Strömungswiderstände in den Atemwegen sind alle als vorwiegende Reflexbronchokonstriktion zu verstehen. Die Vergleiche der Effekte von inhaliertem Histamin mit denjenigen durch Allergen freigesetztem Histamin lassen annehmen, daß die sensorischen Rezeptoren wesentlich näher der Schleimhautoberfläche lokalisiert sind als die Mehrzahl der zur Degranulation kommenden Mastzellen. Hypoxämie verursacht einen geringgradigen Anstieg der Plasma-Histaminkonzentration, wobei der entsprechende Anstieg von Edyn etwa demjenigen vergleichbar ist, wie er bei entsprechender durch allergenbedingter Histaminfreisetzung zustande kommt.
    Notes: Summary Inhalation of acetylcholine causes increased histamine concentration in the arterial plasma. This increase is smaller than that following allergen inhalation. The increase in Edyn following ACH inhalation may be related to the histamine released to only a very limited extent. Comparison of the effects of histamine inhalation and allergen inhalation on Edyn and plasma histamine concentration leads to the assumption that sensory receptors are located nearer to the surface of the mucosa than that of the mast cells. Hypoxemia is followed by a slight increase in the arterial plasma histamine concentration. The increase in Edyn corresponds to that caused by allergen inhalation although the increase in Edyn and that in the plasma histamine are much smaller.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851208
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Histamine release into cracheal lumen and bronchial reactivity (1983)
    Springer
    Research in experimental medicine 182 (1983), S. 167-175 
    Details
    ISSN: 1433-8580
    Keywords: Tracheal lavage ; Pronase ; Acetylcholine ; Histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of tracheal lavage in a restricted area, with a proteolytic enzyme (Pronase) on the bronchial response to challenge with ACH and AE was studied in 15 dogs. Histamine concentrations measured in the tracheal liquid after lavage with Pronase were smaller than the values after tracheal lavage with allergen. Airway response to ACH inhalation was significantly increased after tracheal lavage with Pronase. Effects of proteolytic enzymes and allergens on the tracheal wall are compared. Allergens and proteolytic enzymes evidence a different mode of action in increasing reactivity of peripheral airways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851122
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Histamine release into tracheal lumen and bronchial reactivity (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 67-75 
    Details
    ISSN: 1433-8580
    Keywords: Histamine ; Bronchospastic response ; Acetylcholine ; Tracheal lavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of tracheal lavage with histamine, and of i.v. administration of histamine on bronchospastic response was studied in 16 dogs. Airway response to acetylcholine inhalation was significantly increased after tracheal lavage with high concentrated histamine solution (1%). No influence on airway response was found after (1) tracheal lavage with lower concentrations of histamine and (2) its i.v. administration. The clinical importance of these manifestations is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851764
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Role of vagus nerves and inhalative aerosols of acetylcholine and histamine on dynamic pulmonary elastance in anesthetized spontaneously breathing and artificially ventilated dog (1982)
    Springer
    Research in experimental medicine 181 (1982), S. 155-170 
    Details
    ISSN: 1433-8580
    Keywords: Vagus ; Bronchoconstriction ; Acetylcholine ; Histamine ; Artificial ventilation ; Spontaneous breathing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the vagus nerves on resting respiratory resistance (R1) and dynamic lung elastance (Edyn) and the mechanism of action of inhaled aerosol of histamine (Hist) and acetylcholine (ACH) were studied in anesthetized spontaneously breathing and artificially ventilated dogs. Observations were also extended to study the effect of electrical stimuli to cut ends of both vagi alone and during inhalation of aerosols. Bilateral cervical vagal blockade by local application of novocaine solution (2.5%) or bilateral vagotomy reduced resting R1 and Edyn and prevented increase of these parameters following inhalation of aerosols of Hist or ACH in spontaneously breathing dogs. However, the similar vagal blockade or vagotomy in artificially ventilated animals showed neither an influence on resting R1 and Edyn nor could it prevent their increase following the exposure to aerosol of Hist or ACH. Electrical stimuli to the peripheral cut ends of vagi induced slight increase in R1 and Edyn, but the effect on heart rate and systemic blood pressure was very strong. The combined effects of aerosol of Hist or ACH and electrical stimuli were additive. It is concluded that inhalation of aerosol of Hist or ACH produced two kinds of effects on respiration: (1) Increased respiratory rates with reduced tidal volume and with bronchoconstriction which were vagusdependent (spontaneous breathing model), and (2) bronchoconstriction which was a direct response of smooth muscle without involving a reflex (artificial ventilation model).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851186
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...