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  • 1
    ISSN: 1432-1440
    Keywords: Cis-dichlorodiammine-platinum (II) ; Nephrotoxicity ; Iodo-131-hippurate-clearance ; Serum creatinine ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatininc to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearence nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 73-79 
    ISSN: 1435-2451
    Keywords: Ultrasonographic follow-up examination ; Renal transplantation ; Nuclear procedures ; Local complications after renal transplantation ; Rejection reaction of renal transplant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird berichtet über sonographische Routinekontrollen nach Nierentransplantation bei 72 Patienten. Die Kontrollen sollten in erster Linielokale Komplikationen im Operationsgebiet erfassen und diese gegebenenfalls von einer Abstoßungsreaktion bei nicht eindeutigen klinischen Befunden abgrenzen. Bei den 72 Patienten wurden insgesamt 295 Sonographien durchgeführt. Es fanden sich 22 lokale Komplikationen, von denen 15 im klinisch noch stummen Stadium sonographisch erfaßt wurden. Diese Patienten konnten dann frühzeitig einer chirurgischen bzw. urologischen Behandlung zugeführt werden. Aufgrund dieser Ergebnisse erscheint uns die routinemäßige sonographische Kontrolle des Nierentransplantates zur frühzeitigen Erfassung einer lokalen Komplikation im OP-Gebiet gerechtfertigt, während nuclearmedizinische Methoden bei der Frage nach vasculären Veränderungen und bei gestörter Transplantatfunktion eingesetzt werden sollten.
    Notes: Summary Routine follow-up examinations by ultrasonography after renal transplantation were performed in 72 patients from December 1978 until March 1980. The aim of these controls was to recognizelocal complications in the area of surgery in order to differentiate from a rejection reaction in patients with unclear clinical symptoms. 22 out of 72 patients had local complications. 15 out of those 22 were detected by ultrasound in a state without clinical symptoms, which then could be treated by surgical or urological intervention. We therefore believe that routine follow-up examinations after renal transplantation by ultrasound are indicated in order to recognize local complications. Nuclear procedures should be employed if alteration of blood flow or disturbed function of the transplanted kidney are considered.
    Type of Medium: Electronic Resource
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