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  • 1980-1984  (3)
  • Regeneration  (2)
  • Head regeneration  (1)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 188 (1980), S. 133-139 
    ISSN: 1432-041X
    Keywords: Hydra ; Morphogenetic substances ; Regeneration ; Pattern formation ; Sea anemones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A substance was isolated from crude extracts of hydra that inhibits foot regeneration. This substance, the foot inhibitor, has a molecular weight of ≦500 daltons. It is a hydrophilic molecule, slightly basic in character and it has no peptide bonds. The pruified substance acts specifically and at concentrations lower than 10−7 M. At this low concentration only foot and not head regeneration is inhibited. Hydra are sensitive to purified foot inhibitor between the second and eight hour after initiation of foot regeneration by cutting. In normal animals the foot inhibitor is most likely produced by nerve cells. A substance with similar biological and physico-chemical properties is found in other coelenterates.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 190 (1981), S. 191-196 
    ISSN: 1432-041X
    Keywords: Morphogenetic mutants ; Hydra ; Head regeneration ; Morphogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The mutantreg-16 is deficient in head regeneration and abnormal in size regulation. The gastric region becomes twice as long as that of normal animals before the first bud is produced. Both mutant characteristics are due to changes in head-specific morphogen concentrations.Reg-16 contains twice as much head inhibitor and only half as much head activator in its head as normal animals. This leads to a higher level of free head inhibitor in the whole animal resulting on one hand in a greater distance of buds from the head, and on the other hand in a total blockage of release of head activator and head inhibitor which would be necessary to initiate head regeneration.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 193 (1984), S. 117-118 
    ISSN: 1432-041X
    Keywords: Hydra ; Regeneration ; Head inhibitor ; Foot inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In a recent publication in this journal (Berking 1983) it was claimed (1) that the head inhibitor we isolated from hydra is a Dowex artefact, (2) that a separate foot inhibitor does not exist in hydra and (3) that the only inhibitor that has so far been isolated from hydra is one which inhibits head and foot regeneration equally well. These statements are incorrect and require a response. In the following, I would like to summarise our evidence that the inhibitors isolated from hydra, including Berking's inhibitor, have different specificities for head and foot regeneration. In addition, I would like to show that none of our substances are Dowex artefacts.
    Type of Medium: Electronic Resource
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