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  • 1980-1984  (5)
  • Mice  (2)
  • Neuropeptide Y  (2)
  • Horseradish peroxidase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Distribution, pathways and reactions to drug treatment of nerves with neuropeptide Y- and pancreatic polypeptide-like immunoreactivity in the guinea-pig digestive tract (1983)
    Springer
    Cell & tissue research 234 (1983), S. 71-92 
    Details
    ISSN: 1432-0878
    Keywords: Enteric nervous system ; Intestine ; Noradrenergic nerves ; Pancreatic polypeptide ; Neuropeptide Y ; Neuropeptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pancreatic polypeptide-like immunoreactivity (PPLI) has been localized in nerves of the guinea-pig stomach and intestine with the use of antibodies raised against avian, bovine and human pancreatic polypeptide (PP), the C-terminal hexapeptide of mammalian PP, and against the related peptide, NPY. Each of the antibodies revealed the same population of neurones. Reactive cell bodies were found in both myenteric (5% of all neurones) and submucous ganglia (26% of all neurones) of the small intestine, and varicose processes were observed in the myenteric plexus, circular muscle, mucosa and around arterioles. The nerves were unaffected by bilateral subdiaphragmatic truncal vagotomy, but the staining of the periarterial nerves disappeared after treatment of animals with reserpine or 6-hydroxydopamine and was also absent after mesenteric nerves had been cut and allowed to degenerate. Vascular nerves showing immunoreactivity for dopamine it-hydroxylase and PPLI had the same distribution. It is concluded that PPLI is located in periarterial noradrenergic nerves. However, other noradrenergic nerves in the intestine do not show PPLI, and PPLI also occurs in nerves that are not noradrenergic. Analysis of changes in the distribution of terminals after microsurgical lesions of pathways in the small intestine showed that processes of myenteric PP-nerve cells provide terminals in the underlying circular muscle and in myenteric ganglia up to about 2 mm more anal. Submucous PP-cell bodies provide terminals to the mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217403
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Choline acetyltransferase- and peptide immunoreactivity of submucous neurons in the small intestine of the guinea-pig (1984)
    Springer
    Cell & tissue research 237 (1984), S. 329-336 
    Details
    ISSN: 1432-0878
    Keywords: Choline acetyltransferase ; Cholecystokinin ; Neuropeptide Y ; Somatostatin ; Substance P ; Intestine, small ; Submucous ganglia ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The peptides cholecystokinin (CCK), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and vasoactive intestinal peptide (VIP), and the synthesizing enzyme for acetylcholine, choline acetyltransferase (ChAT) were localized immunohistochemically in nerve cell bodies of the submucous ganglia in the small intestine of the guinea-pig. VIP-like immunoreactivity was found in 45% of submucous neurons. ChAT immunoreactivity was observed in a separate group of nerve cells, which made up 54% of the total population. There were three subsets of neurons immunoreactive for ChAT: (1) ChAT neurons that also contained immunoreactivity for each of the peptides CCK, SOM and NPY, representing 29% of all submucous neurons; (2) ChAT neurons that also contained SP-like immunoreactivity, representing 11% of all submucous neurons, and (3) ChAT cells that did not contain any detectable amount of the peptides that were localized in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217152
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Unimpaired delayed type hypersensitivity reactions in mice infected withTrypanosoma cruzi strain Y (1980)
    Springer
    Parasitology research 61 (1980), S. 179-185 
    Details
    ISSN: 1432-1955
    Keywords: Trypanosoma cruzi ; Delayed hypersensitivity ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Delayed type hypersensitivity reactions (DTH) to DNFB in C3H (susceptible) and (CBA×C57B1/10)F1 (resistant) mice were not impaired inTrypanosoma cruzi strain Y infections. Mice were infected IP with 100 parasites and sensitized or challenged 11 days after infection at the peak of parasitaemia. DTH reactions were found to be enhanced in C3H infected mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00925463
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Humoral suppression inTrypanosoma cruzi infection in relation to the timing of antigen presentation (1980)
    Springer
    Parasitology research 64 (1980), S. 85-93 
    Details
    ISSN: 1432-1955
    Keywords: Trypanosoma cruzi ; Immunosuppression ; Immunenhancement ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract (CBA×C57 B1/10)F1 mice infected intraperitoneally with 100 parasites ofTrypanosoma cruzi strain Y developed an infection with acute and chronic phases. Humoral suppression to sheep red blood cells was evident in both phases but enhancement of the response was achieved only at the beginning of the infection. A mitogen secreted by the parasite could explain both phenomenons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927059
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Projection of ventrolateral medullary (A1) catecholamine neurons toward nucleus tractus solitarii (1981)
    Springer
    Cell & tissue research 220 (1981), S. 27-40 
    Details
    ISSN: 1432-0878
    Keywords: Central catecholamine neurons ; Nucleus tractus solitarii ; Stereotaxic lesions ; Horseradish peroxidase ; Fluorescence microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and interconnections of brainstem catecholamine cell groups thought to be important in cardiovascular control were studied using histochemical and ultrastructural techniques in the rabbit. Lesions and microinjections of horseradish peroxidase (HRP) were made in the nucleus tractus solitarii in the dorsomedial medulla, and in the ventrolateral medulla. After lesions of the dorsomedial medulla the fluorescence intensity of the Al-group of catecholamine neurons was increased, and swollen axons could be seen coursing from the ventrolateral medulla toward the lesions on the same side, but not the opposite side. Most of these axons ran in a band about 2 mm in width, centered at the level of the obex. Electron microscopically, specific cells, identified as A1-catecholamine neurons, showed evidence of chromatolysis after the dorsomedial lesions. Following injection of HRP into the nucleus tractus solitarii, A1-catecholamine cells in the ventrolateral medulla on the same side contained the reaction product. Lesions of the ventrolateral medulla did not produce evidence of a reciprocal projection of A2-catecholamine neurons toward the ventrolateral medulla. Thus axons of the A1-group of catecholamine neurons in the ventrolateral medulla project toward the ipsilateral nucleus tractus solitarii in a relatively compact band at the level of the obex. On the other hand, the A2-group of catecholamine neurons in the dorsomedial medulla does not appear to send projections toward the A1-group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209963
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    Paper (German National Licenses)
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