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  • 1
    Electronic Resource
    Electronic Resource
    Beneficial effect of pancreatic polypeptide in experimental pancreatitis (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 1083-1088 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two animal models have been employed to examine the role of pancreatic polypeptide, a potent and selective inhibitor of pancreatic exocrine secretion, in the treatment of acute pancreatitis. In one model pancreatitis was induced by feeding young female Swiss Webster mice an ethionine-supplemented, choline-deficient diet for 48 hr. Animals (N=30 per group) were injected subcutaneously every 8 hr for 7 days with pancreatic polypeptide (0, 2, 20, and 200 μg/kg/day). Treatment with 20 and 200 μg/kg/day pancreatic polypeptide significantly (P〈0.05) reduced moriality from a control rate of 70% to 42% and 33%, respectively. Treated animals also exhibited significant (P〈0.05) decreases in pancreatic content of activated chymotrypsin and an improvement in pancreatic histology. Pancreatic polypeptide was effective whether treatment was started before or at the same time the test diet was introduced. In contrast, pancreatic polypeptide failed to protect dogs with acute pancreatitis induced by retrograde injection of the pancreas with bile, which may reflect the rapid and mechanical nature of pancreatic damage in this animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01295806
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Time-dependent effects of vagotomy on pancreatic polypeptide release (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 491-494 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been suggested that the pancreatic polypeptide response to a meal is inhibited by truncal vagotomy but returns towards normal with time. We have examined this hypothesis by measuring the pancreatic polypeptide response to a meal in five dogs before and 1 and 6 months after truncal vagotomy. Pancreatic polypeptide responses to food were significantly inhibited (P〈0.01) in both postoperative studies. However, comparison of the 1- and 6-month responses revealed a significant increase (P〈0.05) in the magnitude of the second hour response from 2.3±1.5% of the preoperative response at 1 month to 21.3±9.6% at 6 months. The pancreatic content of pancreatic polypeptide in four vagotomized dogs (1.06±0.06 nmol/g) was not significantly different from normal (1.30±0.33 nmol/g). These studies have shown that truncal vagotomy permanently inhibits the early phase of pancreatic polypeptide release but that the magnitude of the late phase response increases with time. Whether the response would ever return to that observed before vagotomy is uncertain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296726
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric emptying and pancreatic polypeptide response to carbohydrate meals (1985)
    Springer
    Digestive diseases and sciences 30 (1985), S. 52-57 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined pancreatic polypeptide responses to isocaloric meals of radioactively labeled glucose or starch in six normal and seven vagotomized subjects. Liquid glucose meals were ingested with the subject both erect and supine and starch meals were ingested in the upright posture as a solution and as solid balls. In normal subjects, each meal left the stomach at a similar rate and the resultant pancreatic polypeptide responses were not significantly different from one another. Emptying rates varied markedly in vagotomized subjects depending upon the physical consistency of the carbohydrate ingested and the patient's posture. Despite these differences, pancreatic polypeptide responses to each meal were almost identical. These studies demonstrate that the pancreatic polypeptide response to carbohydrate meals is still present several years after vagotomy and is unaffected by alterations in the rate of gastric emptying after vagotomy and by the physical consistency and chemical nature of the carbohydrate ingested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318371
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution, pathways and reactions to drug treatment of nerves with neuropeptide Y- and pancreatic polypeptide-like immunoreactivity in the guinea-pig digestive tract (1983)
    Springer
    Cell & tissue research 234 (1983), S. 71-92 
    Details
    ISSN: 1432-0878
    Keywords: Enteric nervous system ; Intestine ; Noradrenergic nerves ; Pancreatic polypeptide ; Neuropeptide Y ; Neuropeptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pancreatic polypeptide-like immunoreactivity (PPLI) has been localized in nerves of the guinea-pig stomach and intestine with the use of antibodies raised against avian, bovine and human pancreatic polypeptide (PP), the C-terminal hexapeptide of mammalian PP, and against the related peptide, NPY. Each of the antibodies revealed the same population of neurones. Reactive cell bodies were found in both myenteric (5% of all neurones) and submucous ganglia (26% of all neurones) of the small intestine, and varicose processes were observed in the myenteric plexus, circular muscle, mucosa and around arterioles. The nerves were unaffected by bilateral subdiaphragmatic truncal vagotomy, but the staining of the periarterial nerves disappeared after treatment of animals with reserpine or 6-hydroxydopamine and was also absent after mesenteric nerves had been cut and allowed to degenerate. Vascular nerves showing immunoreactivity for dopamine it-hydroxylase and PPLI had the same distribution. It is concluded that PPLI is located in periarterial noradrenergic nerves. However, other noradrenergic nerves in the intestine do not show PPLI, and PPLI also occurs in nerves that are not noradrenergic. Analysis of changes in the distribution of terminals after microsurgical lesions of pathways in the small intestine showed that processes of myenteric PP-nerve cells provide terminals in the underlying circular muscle and in myenteric ganglia up to about 2 mm more anal. Submucous PP-cell bodies provide terminals to the mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217403
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    Paper (German National Licenses)
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