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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 113-124 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid ; Alzheimers disease ; Scrapie ; EM ; Isolation ; Gerstmann-Sträussler syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The structure of partially purified, CNS amyloid fibrils from three different sources have been compared by negative stain EM. The fibrils isolated from brains with senile dementia of Alzheimer type were 4–8 nm in diameter, narrowing every 30–40 nm and apparently composed of two 2–4 nm filaments. The fibrils from a Gerstmann-Sträussler syndrome brain were 7–9 nm in diameter, narrowing every 70–80 nm and with a suggestion that they are composed of two 3–5 nm filaments. The fibrils isolated from 87V scrapie-affected mouse brains were 4–8 nm in diameter with a twist every 15–25 nm presumably composed of two 2–4 nm filaments. The fibrils from the scrapie brains were usually observed in pairs. The shape of the clusters of the isolated amyloid fibrils observed in each disease was similar in negative stain and thin section EM preparations and was related to the characteristic morphology of the amyloid fibrils in the neuritic and amyloid plaques in situ. The structural differences between the CNS amyloid fibrils from the various diseases studied by us may reflect differences in the polypeptides which comprise the fibril and/or a different pathogenesis in the formation of the amyloid fibrils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685355
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 203-211 
    Details
    ISSN: 1432-0533
    Keywords: Ultrastructural cytochemistry ; Plasma membrane phosphatases ; Blood-brain barrier ; Scrapie ; Endothelial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alkaline phosphatase, 5′-nucleotidase nucleoside diphosphatase and thiamine pyrophosphatase activities were studied by cytochemical method applied to electron microscopy of brain microvasculature in normal and scrapie infected mice. In control mice, the major location of all phosphatases studied was the luminal plasma membrane of the endothelial cells. In scrapie infected mice, changes in activity and distribution of the above mentioned phosphatases manifested themselves in the appearance of the reaction product on the abluminal side of the vessel wall. Our data presents evidence that following scrapie infection, these enzymes change their specific localization along the endothelial cell membranes. These enzymatic changes may serve as useful indicators of some alterations in the mammalian blood-brain barrier following infection by scrapie agent in the mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688023
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Abnormal fibrils from scrapie-infected brain (1981)
    Springer
    Acta neuropathologica 54 (1981), S. 63-74 
    Details
    ISSN: 1432-0533
    Keywords: Scrapie ; Fibrils ; Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Abnormal fibrillary structures, designated “scrapie-associated fibrils” (SAF), have been observed using negative stain techniques in subfractions of brains from scrapie-affected animals. SAF have been observed in all combinations of strain of scrapie agent and strain or species of host examined, regardless of their histopathology, in particular the presence or absence of amyloid plaques. SAF consist either of two or four filaments. They are morphologically dissimilar to the normal brain fibrils — microtubules, neurofilaments, glial filaments, and F actin. However, SAF do bear a resemblance to amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691333
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Retinal damage in scrapie mice (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 9-12 
    Details
    ISSN: 1432-0533
    Keywords: Retina ; Scrapie ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Retinal damages in mice infected with serapie are reported. The effects ranged from no histopathological changes, through partial loss of the outer nuclear layer (ONL) to the most severe changes with complete loss of ONL cells and photoreceptors. For the most part, cells of the inner nuclear and ganglion layers were spared. These changes were found in 23% of C57BL/6J mice injected with the ME7 strain of scrapie and in 28.5% of VM mice injected with the 87V strain, while no changes were found in 13 IM mice injected with the 87V strain of scrapie. The possible relation of these changes to scrapie infection and to light induced retinopathy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691175
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    Paper (German National Licenses)
    Fulltext
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