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  • 11
    Electronic Resource
    Electronic Resource
    RNA-tumoriviruses, oncogenes, and their possible role in human carcinogenesis (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1217-1231 
    Details
    ISSN: 1432-1440
    Keywords: RNA tumor viruses ; Human leukemia ; Viral carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The detection and characterization of oncogenes via RNA tumor viruses (or retroviruses) and the recognition of their location at breakpoints of chromosomal translocations which are frequently found in certain human neoplasms has promoted present understanding of molecular mechanisms underlying carcinogenesis. Oncogenes are cellular genes which can be transduced by RNA tumorviruses and induce malignant transformation under experimental conditions in vivo and in vitro. A role of retroviruses in human leukemogenesis is suggested by epidemiological observations and by the isolation of such viruses from several human T-cell leukemias and lymphomas (human T-cell leukemia/lymphoma virus or HTLV) as well as by biochemical association of retroviral markers with human leukemias. A role of HTLV has been suggested also in a human immune deficiency syndrome (AIDS). In view of the well known role of many factors in carcinogenesis the concept of carcinogenesis as a multistep process as well as the concept of cocarcinogenesis and the role of cofactors other than viruses, such as radiation and chemicals, aging, hormones, graft vs host reaction, environmental factors etc., will have to be carefully considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540470
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  • 12
    Electronic Resource
    Electronic Resource
    On the R-order of coupled sequences III (1983)
    Springer
    Computing 30 (1983), S. 157-169 
    Details
    ISSN: 1436-5057
    Keywords: 65H10 ; 15A48 ; Iterative parallel processes ; best individualR-orders ; ordered positive decomposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Für konvergente Folgen {x n,1 },...,{x n,s }, welche über ein System (2) von Ungleichungen miteinander verkoppelt sind, werden die besten individuellenR-Ordnungen τ1,...,τ s bestimmt. Dazu wird gezeigt, daß diese gleich den Spektralradien von bestimmten Matrizen sind, welche aus Exponenten in (2) gebildet werden.
    Notes: Abstract For convergent sequences {x n,1 },...{x n,s } coupled by a system (2) of inequalities the optimal individualR-orders τ1,...,τ s are determined as the spectral radii of certain matrices composed of exponents appearing in (2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280786
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  • 13
    Electronic Resource
    Electronic Resource
    Enclosing methods in perturbed nonlinear operator equations (1984)
    Springer
    Computing 32 (1984), S. 1-11 
    Details
    ISSN: 1436-5057
    Keywords: 65 H ; 65 J ; Nonlinear equation ; monotonous enclosure ; perturbation ; Newton- ; Regula falsi- ; Jacobi-Newton-type methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Es werden nichtlineare Gleichungen betrachtet, die in gewissen Eingangsparametern störungsbehaftet sind. Durch eine Klasse monoton einschließender Verfahren werden Folgen von Intervallen konstruiert, die für jeden Wert der Störungsparameter mindestens eine Nullstelle der Aufgabe enthalten. Für endlich-dimensionale Räume werden u. a. Verfahrensrealisierungen vom Newton-, Regula falsi- und Jacobi-Newton-Typ angegeben.
    Notes: Abstract Nonlinear equations are considered, where some input parameters are subjected to errors. By a class of monotone enclosing methods sequences of intervals are constructed, containing for each value of the perturbation parameter at least one zero of the problem. In finite dimensional spaces concrete realizations are given, e. g. of Newton-, Regula falsi- and Jacobi-Newton-type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02243015
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  • 14
    Electronic Resource
    Electronic Resource
    Determination of the cone radius for positive concave operators (1984)
    Springer
    Computing 33 (1984), S. 37-49 
    Details
    ISSN: 1436-5057
    Keywords: 65H10 ; 90C30 ; 15A48 ; Iterative processes ; bestR-orders ; cone radius of concave operators ; spectral radii ; partial ordering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Die Berechnung der bestenR-Ordnung von Folgen aus iterativen Näherungsverfahren führt auf die Ermittlung des hier eingeführten Kegelradius bestimmter konkaver Operatoren. Das Hauptergebnis der Arbeit ist die Darstellung des Kegelradius als Infimum der Spektralradien aller den konkaven Operator majorisierenden linearen Operatoren. Diese Charakterisierung ist von numerischem Intersse.
    Notes: Abstract The computation of bestR-orders of sequences produced by iterative methods leads to the determination of the cone radius of certain concave operators. The main result of the paper is the representation of the cone radius as the infimum of spectral radii of all linear operators majorizing the concave operator. This characterization is of numerical interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02243074
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  • 15
    Electronic Resource
    Electronic Resource
    Östrogen-und Androgenreceptoren bei Patienten mit Acne vulgaris (1980)
    Springer
    Archives of dermatological research 268 (1980), S. 207-215 
    Details
    ISSN: 1432-069X
    Keywords: Estrogen receptor ; Androgen receptor ; Acne vulgaris ; Östrogenreceptoren ; Androgenreceptoren ; Acne vulgaris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei insgesamt 24 Patienten mit Acne vulgaris wurden Östrogen-und Androgenreceptoren im Biopsiematerial untersucht. Unter den 24 Patienten waren 15 Männer im Alter von 14–40 Jahren und 9 Frauen mit einem Alter von 14–41 Jahren. Als Vergleichskollektiv wurden endokrin gesunde Patienten ausgewählt und normale Hautareale bei 16 Männern und 27 Frauen biopsiert. Das Biopsiematerial bei den Acne-Patienten trug Komedonen, pustulöse oder papulöse Efflorescenzen. Während der Hauptbiopsien wurden in der gleichen Sitzung auch Blutproben zur radioimmunologischen Untersuchung der Testosteron-Serumspiegel entnommen. Die Bestimmung der Östrogen-und Androgenreceptoren wurde mit Hilfe einer Sättigungsanalyse durchgeführt. Als Trennmethode wurde eine Tierkohlenmethode verwendet und die spezifische Bindung durch Parallelinkubationen mit nichtradioaktiv markierten Liganden berechnet. Bei den weiblichen und männlichen endokrin gesunden Kontrollpersonen konnten keine Östrogenreceptoren in der normalen Haut nachgewiesen werden. Bei 93% der männlichen bzw. 78% der weiblichen Acne-Patienten wurden Östrogenreceptoren zwischen 11 und 275 fMol/mg Protein gefunden. Die Untersuchung der Androgenreceptorspiegel bei normaler Haut ergab, daß 31% der männlichen bzw. 48% der weiblichen Vergleichspersonen Androgenreceptorspiegel zwischen 35 und 213 fMol/mg Protein aufwiesen. 40% der männlichen bzw. 100% der weiblichen Acne-Patienten hatten einen positiven Androgenreceptorbefund. Bei den Acne-Patientinnen wurde eine Korrelation von r=0.71 zwischen dem Östrogen und Androgenreceptorspiegel registriert. Keine Korrelation hingegen konnte bei den männlichen Acne-Patienten gefunden werden. Die Auswertung der Testosteron-Serumspiegel und der Androgenreceptorspiegel ergab bei den Acne-Patientinnen eine Korrelation von r=0,77, während die Korrelation bei den männlichen Patienten bei r=0,66 lag. Das Ergebnis der vorliegenden Untersuchung erlaubt den Schluß, daß die größere Receptorempfindlichkeit bei sonst normalem Testosteron-Serumspiegel einer der Faktoren für die Entstehung der Acne sein kann. Die Miteinbeziehung der Receptoruntersuchung gestattet eine bessere Therapieplanung bei den Acne-Patienten. Überdies kann von den vorliegenden Ergebnissen abgeleitet werden, daß männliche Acne-Patienten einer hormonellen Therapie durch Östrogene bzw. Antiöstrogene zugängig sein sollten.
    Notes: Summary Fifteen male and 9 female patients between 14 and 41 years of age who suffered from acne were included in this study. Sixteen endocrine normal males and 27 females were used as controls. Skin and venous blood samples were taken from both normal and acne patients. Specific estrogen and androgen receptor levels were assayed under conditions resulting in the estimation of unoccupied receptor levels, and the charcoal technique was utilized. Testosterone serum levels were determined by radioimmunoassay. No estrogen receptors could be found in the normal skin. Of the male and female acne patients 93 and 78%, respectively, were estrogen receptor-positive, and their levels were between 11 and 275 fmol/mg cytosol protein. On the other hand, 31 and 48%, respectively, of the male and female acne patients were androgen receptor-positive, and their receptor levels were between 35 and 213 fmol/mg cytosol protein. A correlation of r=0.71 between estrogen and androgen receptor levels was noted in the female subjects, but no correlation was found in the male subjects. A correlation between testosterone serum levels and androgen receptor levels of r=0.77 and r=0.66, respectively, was noted in the female and male acne patients. The results of the present investigation suggest that androgen receptor levels play an important role in acne patients with normal testosterone serum levels. In addition, the presence of estrogen receptor levels in acne patients indicates a possible therapy by anti-estrogens or estrogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403804
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  • 16
    Electronic Resource
    Electronic Resource
    Detection of demyelinated plaques with xenon-enhanced computed tomography (1980)
    Springer
    Neuroradiology 20 (1980), S. 181-183 
    Details
    ISSN: 1432-1920
    Keywords: Demyelinated plaques ; Xenonenhanced CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies of xenon-enhanced CT for detecting cerebral demyelination have produced conflicting results. Therefore, we studied the effect of xenon inhalation on the CT appearance of five demyelinated plaques. The plaques and the surrounding white matter increased commensurately in attenuation during xenon inhalation. Therefore, xenon enhancement does not generally increase the sensitivity of CT for detecting cerebral demyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336679
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  • 17
    Electronic Resource
    Electronic Resource
    Mandibular gland allomones ofDasymutilla occidentalis and other mutillid wasps (1980)
    Springer
    Journal of chemical ecology 6 (1980), S. 895-903 
    Details
    ISSN: 1573-1561
    Keywords: Dasymutilla occidentalis ; Dasymutilla ; Timulla ; Pseudomethoca ; Smicromyrme ; Traumatomutilla ; Pappognatha ; Hymenoptera ; Mutillidae ; 4-methyl-3-heptanone ; 4,6-dimethyl-3-nonanone ; 4,6-dimethyl-3-octanone ; allomones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The mandibular gland secretion of the mutillid wasp,Dasymutilla occidentalis, possesses three short-chained ketones-4-methyl-3-heptanone (4MH), 4,6-dimethyl-3-nonanone (4,6DMN), 4,6-dimethyl-3-octanone (4,6DMO)—and several unidentified compounds. This is the first report of 4,6DMN as a natural product and its synthesis is described. These ketones, which are either known to be ant alarm pheromones or are structurally very similar to ant alarm pheromones, appear to function as allomones against ants, major potential predators of mutillid wasps. The major secretory component, 4-methyl-3-heptanone, which was identified in females and/ or males of the species analyzed within the generaDasymutilla, Timulla, Traumatomutilla, andPappognatha, appears to constitute a chemical character of the defensive secretions of these genera.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00990473
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  • 18
    Electronic Resource
    Electronic Resource
    On the factors governing the pressure dependence of the viscosity of moderately concentrated polymer solutionsPart of theses of H. G. and J. R. S. (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 27 (1982), S. 1277-1291 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Viscosity measurements were carried out as a function of pressure and temperature with solutions of polystyrene in eight (endothermal) θ-solvents at the respective critical composition by means of a Searle-type apparatus. A rolling-ball viscometer was used for the investigation of the pure solvents. In all cases the viscosity coefficient increases in a more or less exponential manner when the pressure is raised. For θ-conditions, the volumes of activation of the solutions exceed that of the pure solvent by typically 10-15%. The exact amount of this extra efffect stemming from the presence of the polymer and its variation with temperature can be qualitatively correlated with the heats of mixing. The ratio of the viscosity of the solution at 1000 and 1 bar, respectively, can be varied for a given solvent power (θ-temperature) by the choice of the solvent from ca. 2 (cyclopentane) to 4 (trans-decalin). Within a given system, the maximum effects that can be realized by a change of the solvent power via the variation of temperature ranges from ca. 3 to 6 (tert-butylacetate).
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1982.070270417
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  • 19
    Electronic Resource
    Electronic Resource
    Ein Einschliessungsverfahren für Lösungen Fehlerbehafteter Linearer Gleichungen (1982)
    Springer
    Periodica mathematica Hungarica 13 (1982), S. 29-37 
    Details
    ISSN: 1588-2829
    Keywords: Primary 65F10 ; Secondary 47B55 ; Linear perturbed equations in partially ordered spaces ; monotonically enclosing methods ; computation of initial vectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In a partially ordered space, the method xn+1 = L+x n + − N+x n - − L−y+ + N− y n - + r, yn+1 = N+y+ − L+y n - − N−x n + + L−x− + t of successive approximation is developed in order to enclose the solutions of a set of linear fixed point equations monotonously. The method works if only the inequalities x0 ≤ y0, x0 ≤ x1, y1 ≤ y0 related to the starting elements are satisfied. In finite-dimensional spaces suitable starting vectors can be computed if a sufficiently good approximation for the fixed points is known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01848094
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  • 20
    Electronic Resource
    Electronic Resource
    Massenspektroskopie von Naturstoffen. VII. Massenspektroskopische Untersuchungen von C-3-substituierten stickstoffhaltigen Friedelanen (1980)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 322 (1980), S. 695-700 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass Spectroscopy of Natural Products. VII. Mass Spectroscopic Studies of C-3-substituted Nitrogen Containing Friedelanes
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19803220424
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