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  • 1
    Electronic Resource
    Electronic Resource
    Hexose transport in hybrids between malignant and normal cells (1982)
    [s.l.] : Nature Publishing Group
    Nature 296 (1982), S. 588-588 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT HAS been reported by White et a/.1 that a decreased Km for hexose transport correlates with malignancy in matched pairs of hybrids between malignant and normal cells. Hexose transport was measured by the uptake of 0.1-5 mM 2-deoxy[3H]glucose at 20 C; in these conditions, uptake was found to be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/296588a0
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  • 2
    Electronic Resource
    Electronic Resource
    Myxoviruses do not induce non-specific alterations in membrane permeability early on in infection (1983)
    Springer
    Archives of virology 77 (1983), S. 139-153 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The permeability characteristics of cells infected with myxoviruses have been studied by measuring the concentrative uptake of nutrients, the concentration of intracellular K+, and the maintenance of the Na+ gradient across the plasma membrane. Cells either show no change at all (Sendai virus-infected BHK cells and measles virus-infected Vero cells) or they show a decreased ability to concentrate nutrients, while intracellular K+ and the Na+ gradient remain unchanged (Sendai and influenza virus-infected L-1210 cells, measles virus-infected lymphocytes and mumps virus-infected L-41 cells). In no case, therefore, was a change observed that resembles the non-specific increase in membrane permeability induced by haemolytic paramyxoviruses (35, 42) or the non-specific membrane leakiness postulated to take place in infected cells (8, 9). A preliminary account of some of these findings has been presented (39).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309263
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  • 3
    Electronic Resource
    Electronic Resource
    A novel method for measuring intracellular pH and potassium concentration (1983)
    Springer
    Bioscience reports 3 (1983), S. 631-642 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The concentration of Na+and K+ and the pH in the cytoplasm of Lettré cells was measured by monitoring the net flux of H+, Na+, or K+ across the plasma membrane which had been rendered permeable to these ions by the action of Sendal virus. Ion flux was measured directly by analysis of cell composition, or indirectly by observing the change in membrane potential of cells treated with a specific ionophore. Cytoplasmic concentrations of cations were obtained by establishing the concentration of the cation in the medium at which addition of Sendai virus causes no change in cytoplasmic cation content. The value of Lettré-cell pH was confirmed by direct measurement employing 3tp nuclear magnetic resonance, and the values of Na+ and K+ concentration were confirmed by analysis of cell cation and water content. Lettré cells suspended at 32°C in Hepes-buffered saline at pH 7.3 maintain a cytosolic pH of 7.0 and contain 30 mM Na+ and 80 mM K+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01172873
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  • 4
    Electronic Resource
    Electronic Resource
    Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+ (1984)
    Springer
    Bioscience reports 4 (1984), S. 797-805 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Haemolysis by Sendal virus, α-toxin, and activated complement is inhibited by high concentrations of divalent cations. In Daudi cells, sublytic amounts of these agents induce the following changes: collapse of surface membrane potential, uptake of Na+ and loss of K+ from cells, and leakage of phosphorylated metabo-tites from cells. The changes induced by Sendal virus and complement are sensitive to physiological concentrations of extracellular Ca2+. It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain pore-forming agents on susceptible cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01128822
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma membrane potential of Lettré cells does not depend on cation gradients but on pumps (1984)
    Springer
    The journal of membrane biology 79 (1984), S. 275-284 
    Details
    ISSN: 1432-1424
    Keywords: oxonol-V ; membrane potential ; ion pumps ; Lettré cell ; organic anions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The plasma membrane potential of Lettré cells has been determined with the optical indicator oxonol-V and found to be −57 mV at 37°C (range −20 to −80 mV depending on the physiological condition of the cells). Increasing extracellular K+ does not depolarize cells: even in the presence of 155mM K+ the potential is −41 mV; membrane potential is also insensitive to the chemical gradient of Na+,Mg2+, Ca2+ or Cl−. Ouabain depolarizes the cells; H+ efflux from cells is stimulated by extracellular Na+. We propose that in Lettré cells the plasma membrane potential is generated by electrogenic cation pumps. The balancing fluxes of Na+ and K+ are mainly through electroneutral cation exchanges (Na+/K+ and Na+/H+) and the magnitude of the potential is limited by organic anion leaks. Such a mechanism may operate in other biological membranes also.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871066
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  • 6
    Electronic Resource
    Electronic Resource
    Membrane changes during viral infection (1982)
    Springer
    Bioscience reports 2 (1982), S. 609-612 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314224
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  • 7
    Electronic Resource
    Electronic Resource
    Virally induced alterations in cellular permeability: A basis of cellular and physiological damage? (1981)
    Springer
    Bioscience reports 1 (1981), S. 431-448 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Virally induced permeability changes occur when haemolytic paramyxoviruses are added to cells; similar (though not identical) changes take place during infection of ceils with viruses from several families (including paramyxoviruses). These changes occur in intact) viable cells) and precede subsequent cytopathic effects) to which they are likely to contribute. There is accumulating evidence to suggest that virally induced permeability changes may also underlie the physiological and clinical consequences of viral infection in certain situations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01121577
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Ca2+-antagonists on virally-induced cell-permeability changes (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 2 (1984), S. 249-253 
    Details
    ISSN: 0263-6484
    Keywords: Calcium ; Ca2+-antagonists ; calmodulin ; calmodulin inhibitors ; intracellular cation changes ; permeability changes ; virally-induced permeability changes ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Sendai virus-mediated permeability changes in cells are affected by extracellular Ca2+ or Mn2+ as follows: the lag period to onset of permeability changes is lengthened and the subsequent extent of leakage is reduced. Drugs that block Ca2+ action in excitable cells, such as verapamil and prenylamine, and drugs that inhibit the action of calmodulin, such as trifluoperazine and R24571, have an effect opposite to that of Ca2+: lag is shortened and extent of leakage is increased. The concentration at which either type of drug shows 50% of maximal effect is similar to the concentration at which 50% of binding by drug to calmodulin is achieved. It is concluded that calmodulin may be involved in protecting cells against virally-mediated membrane damage; alternatively the action of calmodulin-binding drugs may not be as specific as currently thought.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290020412
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