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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computing 15 (1975), S. 287-290 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
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  • 2
    Book
    Book
    Koeln :Bachem,
    Title: Datenschutz und Datensicherung
    Author: Dierstein, R.
    Contributer: Fiedler, H. , Schulz, A.
    Publisher: Koeln :Bachem,
    Year of publication: 1976
    Pages: 329 S.
    Type of Medium: Book
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 7 (1978), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Two ostcosarcomas of jaw bones have been studied by electron microscopy. The objectives were to examine the specific cell types in relation to functions and ultrastructural features, and to examine matrices produced by tumor cells.The osteosarcoma cells were subdivided into four cell types: anaplastic, chondroblastic, osteoblastic, and ostcocytic–giant cells were not considered in the present investigation.Compared to normal bone cells, no specific sign of malignancy was found. However, tumor cells seem to lose functional abilities, i.e. a modification of matrix. Consequently, tumor matrix has altered organic and inorganic components with impairment of collagen maturation and matrix mineralization. The alteration in both processes may be related to a diminished production of proteoglycans.The cytogenic hypothesis of a tumor stem cell may be supported by the identification of anaplastic osteosarcoma cells resembling immature reticulum cells. One may speculate on transformation of this cell type as a genetically predetermined osteoprogenitor cell of malignant potential.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Computing 9 (1972), S. 401-404 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 138 (1968), S. 39-43 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zusammenfassung Es wird über Versuche mit Sorboylpalmitat berichtet, einem neuartigen chemischen Hilfsstoff für Brot und andere hefegetriebene Backwaren. Sorboylpalmitat stört die Teiggärung nicht, ist in backtechnischer Hinsicht gut geeignet, beeinflußt die organoleptischen Eigenschaften des Brotes nicht und verhindert des Verschimmeln des Brotes.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 371 (1976), S. 161-170 
    ISSN: 1432-2307
    Keywords: Giant cell granuloma ; Histochemistry ; Ultrastructure ; Cell function ; Osteoclasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die mehrkernigen Riesenzellen des zentralen Riesenzellgranuloms entstehen durch Zellfusion aus den Pericyten der Kapillaren. In der vorliegenden Studie werden die Funktionsmerkmale der Riesenzellen durch Kombination histologischer, histochemischer und elektronenmikroskopischer Methoden untersucht. In den mehrkernigen Riesenzellen ließen sich in Übereinstimmung mit älteren Untersuchungen die lysosomalen Enzyme saure Phosphatase und Aminopeptidase nachweisen. Das lysosomale System der Riesenzellen befähigt diese zur aktiven Phagocytoseleistung. Darüber hinaus können sich die Riesenzellen neugebildeten Geflechtknochenbälkchen anlagern und osteoclastäre Funktionen übernehmen. Die enzymhistochemische und funktioneile Ähnlichkeit mit den mehrkernigen Osteoclasten wirft die Frage nach einer vergleichbaren Cytogenese beider Zellformen auf.
    Notes: Summary Multinucleated giant cells in giant cell granuloma are formed by cell fusion of capillary pericytes. In our present study we tried to analyze cell function and activity by histologic, histochemical, and electronmicroscopic examination of giant cells. Lysosomal enzymes such as acid phosphatase and amino-peptidase were found in giant cells which is in agreement with former work. By their lysosomal system giant cells are proved phagocytic. In addition, giant cells being localized at trabecular surfaces of newly formed woven bone may develop osteoclastic functions. The enzymatic and functional resemblance of giant cells and multinucleated osteoclasts points to the possibility of a similar cytogenesis of both cell types.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 364 (1974), S. 347-356 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An der Metaphysencorticalis der Rattentibia wurde die Entwicklung des Osteocyten mit Hilfe seiner Alters-Lage-Beziehung im Knochen untersucht. Die funktioneilen Veränderungen des Osteocyten und seiner pericellulären Strukturen charakterisieren die verschiedenen ultrastrukturell faßbaren Entwicklungsstadien der Knochenzelle. Aus dem Osteoblasten entsteht über den Matrixosteocyten der junge Osteocyt, der an der Mineralisationsfront der neugebildeten Knochenmatrix liegt. Durch komplette Mineralisation der perilakunären Matrix entwickelt sich der reife Osteocyt. Dieser kann phasisch verschiedene Funktionszustände (inaktiv, formativ, resorptiv) annehmen oder degenerieren. Endstadium ist die Leere Lakune mit Einschluß von Zellresten und Kollagenfasern, die teilweise mineralisieren. Die Kenntnis der aufgeführten Stadien gestattet die Beurteilung experimenteller Veränderungen.
    Notes: Summary Osteocytic development was studied in cortical bone of the tibial metaphysis in the rat, with respect to the relationship between age and localization of the cells. The different development stages through which the osteocytes pass during their life cycle are characterized by functional alterations of the osteocyte itself, as well as pericellular structures of bone substance. The osteoblasts, surrounded by bone matrix, are transformed to matrix osteocytes and then to young osteocytes. The young osteocytes are situated at the mineralization front of newly formed bone matrix. The osteocyte matures through complete mineralization of the perilacunar bone matrix. The mature osteocyte may acquire different functional aspects (inactive, formative, resorptive) or degenerate. The final phase is the empty lacunae, which is mineralized by micropetrosis.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 370 (1976), S. 163-175 
    ISSN: 1432-2307
    Keywords: Central giant cell granuloma ; Histogenesis ; Histochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bisherige Untersuchungen an zentralen Riesenzellgranulomen des Gesichts-Kieferbereiches haben die Histogenese dieser tumorähnlichen Knochenerkrankung nicht klären können. Wir untersuchten daher zwei bioptisch gesicherte zentrale Riesenzellgranulome unter dieser Fragestellung histochemisch und elektronenmikroskopisch. Histochemisch findet sich eine enge Enzymverwandtschaft zwischen den mehrkernigen Riesenzellen und den Pericyten der Kapillaren, die das Granulom dicht durchsetzen. Elektronenmikroskopisch zeigen sich typische Membranphänomene der Zellfusion zwischen den mehrkernigen Riesenzellen und den Pericyten. Die für das Granulom charakteristischen mehrkernigen Riesenzellen entstehen daher durch Zellfusion aus den Pericyten, die als ihre Stammzellen angesehen werden müssen. Da die Pericyten das Granulom auch in Form zahlreicher blinder Kapillarsprossen durchsetzen, erklärt sich die Entwicklung einer Vielzahl von Riesenzellen. Die Ursachen, die diesem Verhalten der Pericyten aetiologisch zugrunde liegen, sind unbekannt. Ob die Cytogenese der Riesenzellen des zentralen Riesenzellgranuloms Modellcharakter hat und analog auch für die Entwicklung von Riesenzellen in anderen Gewebsneubildungen oder für die Enstehung der mehrkernigen Osteoclasten gilt, muß weiteren Untersuchungen vorbehalten bleiben.
    Notes: Summary Until now numerous studies on central giant cell granuloma of jawbones have not been able to reveal the histogenesis of this tumourlike lesion. The aim of the present investigation in two surgically proven cases was to study this question by means of histochemical and electron-microscopic methods. Rather similar histochemieal properties were shown in giant cells and pericytes of capillary sprouts penetrating the granuloma. Cell fusion occurred between both cell types as was observed by electron microscopy. The process of cell fusion is defined by characteristic interdigitations of cell membranes. Therefore pericytes are believed to be the stem cells of multinucleated giant cells in giant cell granuloma. The abundance of giant cells usually occurring in the granuloma might be explained by plenty of capillary sprouts made up by clusters of pericytes. The factors inducing the pericytic cell fusion process are still unknown. The question arises whether cytogenesis of giant cells in giant cell granuloma might be similar in other giant cell lesions or even in the development of multinucleated osteoclasts.
    Type of Medium: Electronic Resource
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