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  • 1975-1979  (20)
  • 1970-1974  (25)
  • 1955-1959  (9)
  • 1830-1839
  • Inorganic Chemistry  (50)
  • Isoprenaline  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Inhibitory effect of tyramine-induced release of catecholamines on renin secretion (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 303 (1978), S. 139-144 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenoceptors ; Renin ; Isoprenaline ; Tyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration. Pretreatment of the rats with reserpine abolished this effect of tyramine, indicating that tyramine released catecholamines which acted on the inhibitory adrenoceptors. Pretreatment with phenoxybenzamine, an α-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that α-adrenoceptors mediated the observed inhibition of renin release. In rats with chronically denervated kidneys tyramine did not inhibit renin release. It is concluded that catecholamines which are released from renal sympathetic nerve endings can suppress renin release by activating α-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508059
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  • 2
    Electronic Resource
    Electronic Resource
    α-Adrenoceptor-mediated inhibitory effect of the sympathetic nervous system on the isoprenaline-induced increase in plasma renin concentration (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 77-82 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenoceptors ; Isoprenaline ; Renin ; Sympathetic nervous system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Ganglionic blockade by trimethidinium (10 mg kg−1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03–0.48 μg kg−1 min−1). Also treatment of the rats with guanethidine (6 mg kg−1) or reserpine (2.5 mg kg−1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 μg kg−1 min−1) on plasma renin concentration. Unilateral renal denervation combined with contralateral nephrectomy doubled the effect of the β-sympathomimetic amine on renin release. The α-adrenoceptor antagonist phenoxybenzamine (3 mg kg−1) also enhanced the effect of isoprenaline on this parameter. It is concluded that apart from a stimulation of renin release via β-adrenoceptors the sympathetic nervous system may inhibit renin release via stimulation of α-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508641
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of neuronal uptake-blocking agents on the increase in water intake and in plasma concentrations of renin and angiotensin I induced by phentolamine and isoprenaline (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 280 (1973), S. 191-200 
    Details
    ISSN: 1432-1912
    Keywords: Phentolamine ; Isoprenaline ; Uptake-Blockers ; Renin-Angiotensin System ; Drinking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increase in water intake, plasma concentration of renin (PRC) and angiotensin I (PAC) induced in rats by the α-sympatholytic agent phentolamine (2.0 mg/kg) is potentiated by the neuronal uptake-blockers cocaine (5.0 mg/kg), desipramine (8.0 mg/kg) and amitriptyline (7.5 mg/kg). The dipsogenic, PRC- and PAC raising activity of the β-mimetic drug isoprenaline (100 μg/kg) remained unaffected by the uptake-blockers used. These results confirm the hypothesis that the increase in PRC is caused by the stimulation of certain β-receptors, which are activated directly by the β-mimetic isoprenaline, while the α-lytic phentolamine does so by a reflex-mediated catecholamine release. These experiments further emphasize the importance of the renin-angiotensin system for the increase in water intake caused by isoprenaline and phentolamine in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499180
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  • 4
    Electronic Resource
    Electronic Resource
    Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 315-321 
    Details
    ISSN: 1432-1912
    Keywords: Isoprenaline ; Renin ; Vasoconstrictors ; Macula densa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of the increase in plasma renin concentration caused by the β-sympathomimetic agent isoprenaline has been further investigated. Rats were pretreated by occluding the left renal artery for 2 hrs, thus rendering the macula densa cells of this kidney nonfunctioning. After contralateral nephrectomy infusion of isoprenaline (1.5 μg/kg min) still caused a strong increase in plasma renin concentration. This increase was significantly suppressed by simultaneous infusion of angiotensin II (1.0 μg/kg min), the α-sympathomimetic amine phenylephrine (60 μg/kg min) or octapressin (10 mU/kg min). The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin. The possibility of a stimulation of renin release via the baroreceptors or a direct “secretomotoric” action of isoprenaline is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510560
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  • 5
    Electronic Resource
    Electronic Resource
    Glykoside von Aminozuckern, II. Zur Synthese von 2-Amino-2-desoxy-α-D-glucopyranosiden (1970)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 103 (1970), S. 1792-1796 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Glycosides of Amino Sugars, II. Synthesis of 2-amino-2-deoxy-α-D-glucopyranosidesThe synthesis of glycosides and disaccharides of 2-amino-2-deoxy-D-glucose has been explored using trifluoroacetyl as the N-blocking group. Because of its high tendency for neighboring group participation only β-D-glycosides were formed. The corresponding α-disaccharide could be obtained as the main product when employing 2.4-dinitrophenyl as the N-protecting group.
    Notes: Die N-Trifluoracetyl-Schutzgruppe wurde zur Synthese von Glykosiden und Disacchariden der 2-Amino-2-desoxy-D-glucose benutzt. Sie zeigte eine hohe Tendenz zur Nachbargruppen-beteiligung unter Bildung von -β-D-Glykosiden. Das entsprechende α-Disaccharid wurde als Hauptprodukt bei Verwendung der N-2.4-Dinitrophenyl-Schutzgruppe erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19701030614
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  • 6
    Electronic Resource
    Electronic Resource
    Di- und Polyaminozucker, XV.XIV. Mitteil.: W. Meyer zu Reckendorf, Tetrahedron Letters [London] 1970, 287 Synthese der 2.4-Diamino-l.6-anhydro-2.4-didesoxy-D-talose (1970)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 103 (1970), S. 2424-2427 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Di- and Polyamino Sugars, XV. XIV. Mitteil.: W. Meyer zu Reckendorf, Tetrahedron Letters [London] 1970, 287. Synthese der 2.4-Diamino-1.6-anhydro-2.4-dideoxy-D-talose. Synthesis of 2,4-Diamino-1,6-anhydro-2,4-dideoxy-D-taloseDehydrogenation of the amino reductone 1 with iodine yields a triulose which is isolated as the phenylhydrazone-phenylazo derivative 2. Spontaneous cyclization of 2 forms the 1.6-anhydro compound 3. On hydrogenation 2as well as 3are transformed into the title compound.
    Notes: Die durch Dehydrierung des Aminoreduktons 1 mit Jod entstehende Triulose wird als Bis-phenylhydrazon 2 isoliert, das die Konstitution eines Phenylhydrazon-benzolazo-Derivates besitzt. 2 cyclisiert leicht zur 1.6-Anhydro-Verbindung 3, die, wie auch 2, bei der katalytischen Hydrierung die Titelverbindung liefert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19701030814
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  • 7
    Electronic Resource
    Electronic Resource
    Die Kondensation von cyclischen arylkonjugierten α-Brom-ketonen mit Formaldehyd (1970)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 103 (1970), S. 2084-2090 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Condensations of Cyclic Aryl-conjugated α-Bromoketones with FormaldehydeReactions of carbocyclic and heterocyclic α-bromoketones with formaldehyde yield α-epoxy-α-methylketones or α, β-unsaturated α-(hydroxymethyl)ketones.
    Notes: Die Umsetzung einer Reihe von carbocyclischen und heterocyclischen α-Brom-ketonen mit Formaldehyd ergibt α-Epoxy-α-methyl-ketone oder α. β-ungesättigte α-Hydroxymethyl-ketone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19701030710
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  • 8
    Electronic Resource
    Electronic Resource
    Synthese von 2.-3[Carboxymethylen]- und 2.-3[2-Hydroxy-äthyliden]-2.3-didesoxy-D-mannose  -  Monosacchariden mit einem Cyclopropanring (1972)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 105 (1972), S. 673-685 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis of 2.-3(Carboxymethylene)- and 2.-3(2-Hydroxyethylidene)-2.3-dideoxy-D-mannose  -  Monosaccharides with a Cyclopropane RingThe anhydro derivative 1 yielded the cyclopropane carboxylic ester 2 in a PO-activated olefination reaction. Under mild conditions 2 could be hydrolised to the free carboxylic acid 5. By reduction the cyclopropyl carbinol 13 and the cyclopropane carbaldehyde 21 were formed. The latter could be rearranged to the cyclobutene derivative 25. Attempts to synthesize a cyclopropanol were unsuccessful.
    Notes: Durch PO-aktivierte Olefinierung entstand aus der Anhydro-Verbindung 1 der Cyclopropancarbonsäureester 2, der unter milden Bedingungen zur freien Carbonsäure 5 hydrolysiert werden konnte. Reduktion lieferte das Cyclopropylcarbinol 13 und den Cyclopropan-carbaldehyd 21, der zum Cyclobutenderivat 25 umgelagert wurde. Die Synthese eines Cyclopropanols gelang nicht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19721050233
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  • 9
    Electronic Resource
    Electronic Resource
    Di- und Polyaminozucker, XXI. Synthese von Derivaten der 2,4-Diamino-2,3,4-tridesoxy-D-ribo-hexose (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 3397-3411 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Di-and Polyamino Sugars, XXI. Synthesis of Derivatives of 2,4-Diamino-2,3,4-trideoxy-D-ribo-hexoseStarting with D-glucose the title compound has been synthesized as its di-N-acetyl. -trifluoroacetyl and N,N′-bis(2,4-dinitrophenyl) derivative. The free sugar could not be obtained in a pure state.
    Notes: Die Titelverbindung wurde, ausgehend von D-Glucose, in Form ihres Di-N-acetyl-, -trifluoracetyl- und ihres N,N′-Bis(2,4-dinitrophenyl)-Derivates erhalten. Reindarstellung des freien Zuckers gelang nicht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751081031
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  • 10
    Electronic Resource
    Electronic Resource
    Heterocyclische Siebenring-Verbindungen, XVI. Synthese gezielt 3,5-substituierter 4-Phenyl-1-benzothiepine (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 3596-3610 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Heterocyclic Seven-membered Ring Compounds, XVI. Synthesis of 3,5-Substituted 4-Phenyl-1-benzothiepins4-Phenyl-1-benzothiepins 7 and 8 are synthesized starting from their 5-methoxy-2,3-dihydro-precursor 2; using the 2,5-dihydro-intermediate 12 yields the 4-phenyl-1-benzothiepins 13 and 14. The 1-benzothiepin 17 can be obtained from the diketone 1 directly. The 3-cyano-substituted compound 22 is prepared from its 2,5-dihydro-precursor 21. Some ring-contraction and ring-cleavage reactions of the heterocyclic seven-membered ring-system are described.
    Notes: Die 5-Methoxy-2,3-dihydro-Vorstufe 2 wird in die 4-Phenyl-1-benzothiepine 7 und 8 übergeführt; aus der 2,5-Dihydro-Vorstufe 12 werden die 4-Phenyl-1-benzothiepine 13 und 14 dargestellt. Das 1-Benzothiepin 17 wird direkt aus dem Siebenring-Diketon 1 erhalten. Das 3-cyan-substituierte 1-Benzothiepin 22 erhält man aus der 2,5-Dihydro-Vorstufe 21. Es werden einige Ringverengungsbzw. Ringspaltungsreaktionen des heterocyclischen Siebenring-Systems beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751081121
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